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CUTTING EDGE |
-Galactosylceramide1
*
CREST (Core Research for Evolutional Science and Technology) Project and Department of Molecular Immunology, Graduate School of Medicine, School of Medicine, and
Second Department of Surgery, School of Medicine, Chiba University, Chiba, Japan
A unique lymphoid lineage, V
14 NKT cells, bearing an
invariant Ag receptor encoded by V14 and J281 gene segments, play
crucial roles in various immune responses, including protective
immunity against malignant tumors. A specific ligand of V14 NKT
cells is determined to be -galactosylceramide (-GalCer) which is
presented by the CD1d molecule. Here, we report that dendritic cells
(DCs) pulsed with -GalCer effectively induce potent antitumor
cytotoxic activity by specific activation of V14 NKT cells,
resulting in the inhibition of tumor metastasis in vivo. Moreover, a
complete inhibition of B16 melanoma metastasis in the liver was
observed when -GalCer-pulsed DCs were injected even 7 days after
transfer of tumor cells to syngeneic mice where small but multiple
metastatic nodules were already formed. The potential utility of DCs
pulsed with -GalCer for tumor immunotherapy is
discussed.
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Z. Trobonjaca, F. Leithauser, P. Moller, R. Schirmbeck, and J. Reimann Activating Immunity in the Liver. I. Liver Dendritic Cells (but Not Hepatocytes) Are Potent Activators of IFN-{gamma} Release by Liver NKT Cells J. Immunol., August 1, 2001; 167(3): 1413 - 1422. [Abstract] [Full Text] [PDF]
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M. J. Smyth, E. Cretney, K. Takeda, R. H. Wiltrout, L. M. Sedger, N. Kayagaki, H. Yagita, and K. Okumura Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Contributes to Interferon {{gamma}}-dependent Natural Killer Cell Protection from Tumor Metastasis J. Exp. Med., March 12, 2001; 193(6): 661 - 670. [Abstract] [Full Text] [PDF]
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K. Kawakami, Y. Kinjo, S. Yara, Y. Koguchi, K. Uezu, T. Nakayama, M. Taniguchi, and A. Saito Activation of V{alpha}14+ Natural Killer T Cells by {alpha}-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans Infect. Immun., January 1, 2001; 69(1): 213 - 220. [Abstract] [Full Text] [PDF]
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O. O. Yang, F. K. Racke, P. T. Nguyen, R. Gausling, M. E. Severino, H. F. Horton, M. C. Byrne, J. L. Strominger, and S. B. Wilson CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of V{alpha}24J{alpha}Q T Cells: A Feedback Mechanism for Immune Regulation J. Immunol., October 1, 2000; 165(7): 3756 - 3762. [Abstract] [Full Text] [PDF]
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I. Apostolou, A. Cumano, G. Gachelin, and P. Kourilsky Evidence for Two Subgroups of CD4-CD8- NKT Cells with Distinct TCR{alpha}{beta} Repertoires and Differential Distribution in Lymphoid Tissues J. Immunol., September 1, 2000; 165(5): 2481 - 2490. [Abstract] [Full Text] [PDF]
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