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CUTTING EDGE |
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Laboratory of Immunology and Vascular Biology, Department of Pathology, and the Digestive Disease Center, Department of Medicine, Stanford University Medical School, Stanford, CA, 94305; and
Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304
We show that developmental transitions during thymocyte maturation are associated with dramatic changes in chemotactic responses to chemokines. Macrophage-derived chemokine, a chemokine expressed in the thymic medulla, attracts thymocytes only during a brief window of development, between the late cortical and early medullary stages. All medullary phenotypes (CD4 or CD8 single positive) but not immature thymocytes respond to the medullary stroma-expressed (and secondary lymphoid tissue-associated) chemokines secondary lymphoid-tissue chemokine and macrophage inflammatory protein-3ß. The appearance of these responses is associated with the phenotypic stage of cortex to medulla migration and with up-regulation of mRNA for the receptors CCR4 (for macrophage-derived chemokine and thymus and activation-regulated chemokine) and CCR7 (for secondary lymphoid-tissue chemokine and macrophage inflammatory protein-3ß). In contrast, most immature and medullary thymocytes migrate to thymus-expressed chemokine, an ability that is lost only with up-regulation of the peripheral homing receptor L-selectin during the latest stages of thymocyte maturation associated with export to the periphery. Developmental switches in chemokine responses may help regulate critical migratory events during T cell development.
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S. Uehara, K. Song, J. M. Farber, and P. E. Love Characterization of CCR9 Expression and CCL25/Thymus-Expressed Chemokine Responsiveness During T Cell Development: CD3highCD69+ Thymocytes and {gamma}{delta}TCR+ Thymocytes Preferentially Respond to CCL25 J. Immunol., January 1, 2002; 168(1): 134 - 142. [Abstract] [Full Text] [PDF]
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F. Vinante, A. Rigo, M. T. Scupoli, and G. Pizzolo CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 Blood, January 1, 2002; 99(1): 52 - 60. [Abstract] [Full Text] [PDF]
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M.-A. Wurbel, M. Malissen, D. Guy-Grand, E. Meffre, M. C. Nussenzweig, M. Richelme, A. Carrier, and B. Malissen Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gamma delta + gut intraepithelial lymphocytes Blood, November 1, 2001; 98(9): 2626 - 2632. [Abstract] [Full Text] [PDF]
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 J. R. Taylor Jr., K. C. Kimbrell, R. Scoggins, M. Delaney, L. Wu, and D. Camerini Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1 J. Virol., September 15, 2001; 75(18): 8752 - 8760. [Abstract] [Full Text] [PDF]
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S. Vandenabeele, H. Hochrein, N. Mavaddat, K. Winkel, and K. Shortman Human thymus contains 2 distinct dendritic cell populations Blood, March 15, 2001; 97(6): 1733 - 1741. [Abstract] [Full Text] [PDF]
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P. Hjelmström Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines J. Leukoc. Biol., March 1, 2001; 69(3): 331 - 339. [Abstract] [Full Text]
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L. Carramolino, A. Zaballos, L. Kremer, R. Villares, P. Martin, C. Ardavin, C. Martinez-A, and G. Marquez Expression of CCR9 {beta}-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs Blood, February 15, 2001; 97(4): 850 - 857. [Abstract] [Full Text] [PDF]
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P. Romagnani, F. Annunziato, E. Lazzeri, L. Cosmi, C. Beltrame, L. Lasagni, G. Galli, M. Francalanci, R. Manetti, F. Marra, et al. Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) {alpha}{beta}+CD8+ single-positive T cells, TCR{gamma}{delta}+ T cells, and natural killer-type cells in human thymus Blood, February 1, 2001; 97(3): 601 - 607. [Abstract] [Full Text] [PDF]
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J. J. Campbell, K. E. Murphy, E. J. Kunkel, C. E. Brightling, D. Soler, Z. Shen, J. Boisvert, H. B. Greenberg, M. A. Vierra, S. B. Goodman, et al. CCR7 Expression and Memory T Cell Diversity in Humans J. Immunol., January 15, 2001; 166(2): 877 - 884. [Abstract] [Full Text] [PDF]
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L. Kremer, L. Carramolino, I. Goya, A. Zaballos, J. Gutierrez, M. del Carmen Moreno-Ortiz, C. Martinez-A., and G. Marquez The Transient Expression of C-C Chemokine Receptor 8 in Thymus Identifies a Thymocyte Subset Committed to Become CD4+ Single-Positive T Cells J. Immunol., January 1, 2001; 166(1): 218 - 225. [Abstract] [Full Text] [PDF]
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K. A. Papadakis, J. Prehn, V. Nelson, L. Cheng, S. W. Binder, P. D. Ponath, D. P. Andrew, and S. R. Targan The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System J. Immunol., November 1, 2000; 165(9): 5069 - 5076. [Abstract] [Full Text] [PDF]
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J. Pan, E. J. Kunkel, U. Gosslar, N. Lazarus, P. Langdon, K. Broadwell, M. A. Vierra, M. C. Genovese, E. C. Butcher, and D. Soler Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues J. Immunol., September 15, 2000; 165(6): 2943 - 2949. [Abstract] [Full Text] [PDF]
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A. Mantovani, P. A. Gray, J. Van Damme, and S. Sozzani Macrophage-derived chemokine (MDC) J. Leukoc. Biol., September 1, 2000; 68(3): 400 - 404. [Abstract] [Full Text] [PDF]
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F. Annunziato, P. Romagnani, L. Cosmi, C. Beltrame, B. H. Steiner, E. Lazzeri, C. J. Raport, G. Galli, R. Manetti, C. Mavilia, et al. Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection J. Immunol., July 1, 2000; 165(1): 238 - 246. [Abstract] [Full Text] [PDF]
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C. Boileau, M. Houde, G. Dulude, C. H. Clegg, and C. Perreault Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M J. Immunol., June 1, 2000; 164(11): 5713 - 5720. [Abstract] [Full Text] [PDF]
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 V. L. Schweickart, A. Epp, C. J. Raport, and P. W. Gray CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines J. Biol. Chem., March 24, 2000; 275(13): 9550 - 9556. [Abstract] [Full Text] [PDF]
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C.-R. Yu, K. W. C. Peden, M. B. Zaitseva, H. Golding, and J. M. Farber CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand J. Immunol., February 1, 2000; 164(3): 1293 - 1305. [Abstract] [Full Text] [PDF]
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A. M. Norment, L. Y. Bogatzki, B. N. Gantner, and M. J. Bevan Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling J. Immunol., January 15, 2000; 164(2): 639 - 648. [Abstract] [Full Text] [PDF]
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