| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Producing Lymphocytes Is a Manifestation of Immunologic Memory and Correlates with the Risk of Posttransplant Rejection Episodes
,§
Departments of
*
Medicine,
Pathology, and
Surgery and
§
Histocompatibility Laboratory, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, OH, 44106
While matching for MHC Ags improves renal allograft survival,
closely matched grafts sometimes fail due to rejection, and poorly
matched allografts are often well tolerated by the recipient. The
severity of the rejection process may partially depend on the presence
of environmentally primed T cells in the recipient that cross-react
with donor Ags. To test for the presence of primed, donor-specific T
cells in humans before transplantation, we used an enzyme-linked
immunospot assay for detection of allospecific cytokines produced by
individual human PBLs. We demonstrate that this approach detects
cytokine production at single cell resolution and detects production of
IFN-
only when there is defined immunologic priming, thus
representing a measure of primed donor-specific immunity. Because the
environmental Ag exposure of the recipient is not a function of the HLA
mismatch between donor and potential recipient, the number of HLA
mismatches may not correlate with the frequency of pretransplant,
donor-specific IFN--producing PBLs. Studies of donor-specific
IFN--producing lymphocytes in a cohort of patients being evaluated
for renal transplantation corroborated this hypothesis. Moreover, for
recipients of both living and cadaver renal allografts, the
pretransplant frequency of donor-specific memory cells correlated with
the posttransplant risk of developing acute rejection episodes. This
improved ability to define the strength of the allospecific immune
response by enzyme-linked immunospot assay may allow improved pairing
of recipients with donors and identification of kidney allograft
donor-recipient pairs at high risk for acute rejection, thus permitting
targeted interventions aimed at prolonging graft
survival.
This article has been cited by other articles:
|
|
 |
|
  A. E. Anderson, B. L. Sayers, M. A. Haniffa, D. J. Swan, J. Diboll, X.-N. Wang, J. D. Isaacs, and C. M. U. Hilkens Differential regulation of naive and memory CD4+ T cells by alternatively activated dendritic cells J. Leukoc. Biol., July 1, 2008; 84(1): 124 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Bestard, P. Nickel, J. M. Cruzado, C. Schoenemann, O. Boenisch, A. Sefrin, J. M. Grinyo, H.-D. Volk, and P. Reinke Circulating Alloreactive T Cells Correlate with Graft Function in Longstanding Renal Transplant Recipients J. Am. Soc. Nephrol., July 1, 2008; 19(7): 1419 - 1429. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Metzler, P. Gfeller, G. Wieczorek, J. Li, B. Nuesslein-Hildesheim, A. Katopodis, M. Mueller, and V. Brinkmann Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure Int. Immunol., May 1, 2008; 20(5): 633 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Bobadilla, R. B. Love, E. Jankowska-Gan, Q. Xu, L. D. Haynes, R. K. Braun, M. S. Hayney, A. Munoz del Rio, K. Meyer, D. S. Greenspan, et al. Th-17, Monokines, Collagen Type V, and Primary Graft Dysfunction in Lung Transplantation Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 660 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Wang, H. Dai, N. Wan, Y. Moore, and Z. Dai The Role for Monocyte Chemoattractant Protein-1 in the Generation and Function of Memory CD8+ T Cells J. Immunol., March 1, 2008; 180(5): 2886 - 2893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wan, H. Dai, T. Wang, Y. Moore, X. X. Zheng, and Z. Dai Bystander Central Memory but Not Effector Memory CD8+ T Cells Suppress Allograft Rejection J. Immunol., January 1, 2008; 180(1): 113 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Shiao, N. C. Kirkiles-Smith, B. R. Shepherd, J. M. McNiff, E. J. Carr, and J. S. Pober Human Effector Memory CD4+ T Cells Directly Recognize Allogeneic Endothelial Cells In Vitro and In Vivo J. Immunol., October 1, 2007; 179(7): 4397 - 4404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Bestard, J. M. Cruzado, M. Mestre, A. Caldes, J. Bas, M. Carrera, J. Torras, I. Rama, F. Moreso, D. Seron, et al. Achieving Donor-Specific Hyporesponsiveness Is Associated with FOXP3+ Regulatory T Cell Recruitment in Human Renal Allograft Infiltrates J. Immunol., October 1, 2007; 179(7): 4901 - 4909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. O'Keefe, L. Gondek, R. Davis, E. Kuczkowski, R. M. Sobecks, A. Rodriguez, Y. Narvaez, Z. McIver, R. Tuthill, M. Laughlin, et al. Molecular Analysis of Alloreactive CTL Post-Hemopoietic Stem Cell Transplantation J. Immunol., August 1, 2007; 179(3): 2013 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Valujskikh and X. C. Li Frontiers in Nephrology: T Cell Memory as a Barrier to Transplant Tolerance J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2252 - 2261. [Full Text] [PDF]
|
|
|
|
|
|
L. K. Selin and M. A. Brehm Frontiers in Nephrology: Heterologous Immunity, T Cell Cross-Reactivity, and Alloreactivity J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2268 - 2277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Augustine, E. D. Poggio, M. Clemente, M. I. Aeder, K. A. Bodziak, J. A. Schulak, P. S. Heeger, and D. E. Hricik Hemodialysis Vintage, Black Ethnicity, and Pretransplantation Antidonor Cellular Immunity in Kidney Transplant Recipients J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1602 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, H. Dai, N. Wan, T. Wang, S. Bertera, M. Trucco, and Z. Dai Suppression of Memory CD8 T Cell Generation and Function by Tryptophan Catabolism J. Immunol., April 1, 2007; 178(7): 4260 - 4266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Brehm, J. Mangada, T. G. Markees, T. Pearson, K. A. Daniels, T. B. Thornley, R. M. Welsh, A. A. Rossini, and D. L. Greiner Rapid quantification of naive alloreactive T cells by TNF-{alpha} production and correlation with allograft rejection in mice Blood, January 15, 2007; 109(2): 819 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. S. Kim, S. H. Yang, H. G. Kang, E. Y. Seong, S. H. Lee, W. Gao, J. Kenny, X. X. Zheng, and T. B. Strom Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance Int. Immunol., December 1, 2006; 18(12): 1771 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Mannon and A. D. Kirk Beyond Histology: Novel Tools to Diagnose Allograft Dysfunction Clin. J. Am. Soc. Nephrol., May 1, 2006; 1(3): 358 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gallon, E. Gagliardini, A. Benigni, D. Kaufman, A. Waheed, M. Noris, and G. Remuzzi Immunophenotypic Analysis of Cellular Infiltrate of Renal Allograft Biopsies in Patients with Acute Rejection after Induction with Alemtuzumab (Campath-1H) Clin. J. Am. Soc. Nephrol., May 1, 2006; 1(3): 539 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Koehn, S. Gangappa, J. D. Miller, R. Ahmed, and C. P. Larsen Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation. J. Immunol., March 1, 2006; 176(5): 2691 - 2696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Vu, M. R. Clarkson, H. Yagita, L. A. Turka, M. H. Sayegh, and X. C. Li Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection J. Immunol., February 1, 2006; 176(3): 1394 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Poggio, M. Clemente, D. E. Hricik, and P. S. Heeger Panel of Reactive T Cells as a Measurement of Primed Cellular Alloimmunity in Kidney Transplant Candidates J. Am. Soc. Nephrol., February 1, 2006; 17(2): 564 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Iacomini and M. H. Sayegh Measuring T Cell Alloreactivity to Predict Kidney Transplant Outcomes: Are We There Yet? J. Am. Soc. Nephrol., February 1, 2006; 17(2): 328 - 330. [Full Text] [PDF]
|
|
|
|
|
|
H. Andree, P. Nickel, C. Nasiadko, M. H. Hammer, C. Schonemann, A. Pruss, H.-D. Volk, and P. Reinke Identification of Dialysis Patients with Panel-Reactive Memory T Cells before Kidney Transplantation Using an Allogeneic Cell Bank J. Am. Soc. Nephrol., February 1, 2006; 17(2): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhang, Y. Chen, R. L. Fairchild, P. S. Heeger, and A. Valujskikh Lymphoid Sequestration of Alloreactive Memory CD4 T Cells Promotes Cardiac Allograft Survival J. Immunol., January 15, 2006; 176(2): 770 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Baeten, S. Louis, C. Braud, C. Braudeau, C. Ballet, F. Moizant, A. Pallier, M. Giral, S. Brouard, and J.-P. Soulillou Phenotypically and Functionally Distinct CD8+ Lymphocyte Populations in Long-Term Drug-Free Tolerance and Chronic Rejection in Human Kidney Graft Recipients J. Am. Soc. Nephrol., January 1, 2006; 17(1): 294 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Shiao, J. M. McNiff, and J. S. Pober Memory T Cells and Their Costimulators in Human Allograft Injury J. Immunol., October 15, 2005; 175(8): 4886 - 4896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R P Anderson, D A van Heel, J A Tye-Din, M Barnardo, M Salio, D P Jewell, and A V S Hill T cells in peripheral blood after gluten challenge in coeliac disease Gut, September 1, 2005; 54(9): 1217 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Hauser, S. Spiegler, E. Kiss, S. Gauer, O. Sichler, E. H. Scheuermann, H. Ackermann, J. M. Pfeilschifter, H. Geiger, H.-J. Grone, et al. Prediction of Acute Renal Allograft Rejection by Urinary Monokine Induced by IFN-{gamma} (MIG) J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1849 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. W. Nasr, Y. Wang, G. Gao, S. Deng, L. Diggs, D. M. Rothstein, G. Tellides, F. G. Lakkis, and Z. Dai Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells J. Immunol., May 15, 2005; 174(10): 6161 - 6168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Poggio, M. Clemente, J. Riley, M. Roddy, N. S. Greenspan, C. Dejelo, N. Najafian, M. H. Sayegh, D. E. Hricik, and P. S. Heeger Alloreactivity in Renal Transplant Recipients with and without Chronic Allograft Nephropathy J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1952 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. El-Sawy, M. Miura, and R. Fairchild Early T Cell Response to Allografts Occuring Prior to Alloantigen Priming Up-Regulates Innate-Mediated Inflammation and Graft Necrosis Am. J. Pathol., July 1, 2004; 165(1): 147 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, P. S. Heeger, and A. Valujskikh In Vivo Helper Functions of Alloreactive Memory CD4+ T Cells Remain Intact Despite Donor-Specific Transfusion and Anti-CD40 Ligand Therapy J. Immunol., May 1, 2004; 172(9): 5456 - 5466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. Lakkis Transplantation tolerance: a journey from ignorance to memory Nephrol. Dial. Transplant., October 1, 2003; 18(10): 1979 - 1982. [Full Text] [PDF]
|
|
|
|
|
|
F. G. Lakkis and M. H. Sayegh Memory T Cells: A Hurdle to Immunologic Tolerance J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2402 - 2410. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Brehm, T. G. Markees, K. A. Daniels, D. L. Greiner, A. A. Rossini, and R. M. Welsh Direct Visualization of Cross-Reactive Effector and Memory Allo-Specific CD8 T Cells Generated in Response to Viral Infections J. Immunol., April 15, 2003; 170(8): 4077 - 4086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Karpinski, D. Rush, J. Jeffery, D. Pochinco, D. Milley, and P. Nickerson Heightened Peripheral Blood Lymphocyte CD69 Expression is Neither Sensitive nor Specific as a Noninvasive Diagnostic Test for Renal Allograft Rejection J. Am. Soc. Nephrol., January 1, 2003; 14(1): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pantenburg, F. Heinzel, L. Das, P. S. Heeger, and A. Valujskikh T Cells Primed by Leishmania major Infection Cross-React with Alloantigens and Alter the Course of Allograft Rejection J. Immunol., October 1, 2002; 169(7): 3686 - 3693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chalasani, Z. Dai, B. T. Konieczny, F. K. Baddoura, and F. G. Lakkis Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs PNAS, April 30, 2002; 99(9): 6175 - 6180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Najafian, A. D. Salama, E. V. Fedoseyeva, G. Benichou, and M. H. Sayegh Enzyme-Linked Immunosorbent Spot Assay Analysis of Peripheral Blood Lymphocyte Reactivity to Donor HLA-DR Peptides: Potential Novel Assay for Prediction of Outcomes for Renal Transplant Recipients J. Am. Soc. Nephrol., January 1, 2002; 13(1): 252 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Heeger and D. Hricik Immune Monitoring in Kidney Transplant Recipients Revisited J. Am. Soc. Nephrol., January 1, 2002; 13(1): 288 - 290. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Baker, M. P. Hernandez-Fuentes, P. A. Brookes, A. N. Chaudhry, H. T. Cook, and R. I. Lechler Loss of Direct and Maintenance of Indirect Alloresponses in Renal Allograft Recipients: Implications for the Pathogenesis of Chronic Allograft Nephropathy J. Immunol., December 15, 2001; 167(12): 7199 - 7206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Hesse, A. Y. Karulin, B. O. Boehm, P. V. Lehmann, and M. Tary-Lehmann A T Cell Clone's Avidity Is a Function of Its Activation State J. Immunol., August 1, 2001; 167(3): 1353 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Heeger, A. Valujskikh, and P. V. Lehmann23 Comprehensive Assessment of Determinant Specificity, Frequency, and Cytokine Signature of the Primed CD8 Cell Repertoire Induced by a Minor Transplantation Antigen J. Immunol., August 1, 2000; 165(3): 1278 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Schwander, M. Torres, C. Carranza C, D. Escobedo, M. Tary-Lehmann, P. Anderson, Z. Toossi, J. J. Ellner, E. A. Rich, and E. Sada Pulmonary Mononuclear Cell Responses to Antigens of Mycobacterium tuberculosis in Healthy Household Contacts of Patients with Active Tuberculosis and Healthy Controls from the Community J. Immunol., August 1, 2000; 165(3): 1479 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Hartig, G. W. Haller, D. H. Sachs, S. Kuhlenschmidt, and P. S. Heeger Naturally Developing Memory T Cell Xenoreactivity to Swine Antigens in Human Peripheral Blood Lymphocytes J. Immunol., March 1, 2000; 164(5): 2790 - 2796. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
