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Eß7+ T Cells Around Acinar Epithelial Cells with Apoptosis in Patients with Sjögren’s Syndrome1
*
Department of Ophthalmology and Oral Health Science Center, Tokyo Dental College, Chiba, Japan; and
Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, Japan
The T lymphocytes that infiltrate the exocrine glands in
Sjögren’s syndrome (SS) play a key role in damaging glandular
epithelial cells, but the mechanisms of this damage by T lymphocytes
are not fully understood. To determine the cellular basis of this
phenomenon, we focused our attention on the T lymphocytes around acinar
epithelial cells in SS. We showed that CD8+ but not
CD4+ T lymphocytes were located around the acinar
epithelial cells and that a majority of these CD8+ T
lymphocytes possess an unique integrin,
Eß7 (CD103). The acinar epithelial cell
adherent with Eß7 (CD103)+
CD8+ T lymphocytes was apoptotic. Both the
perforin/granzyme B and Fas/Fas ligand pathways were implicated in the
process of programmed cell death in lacrimal glands. These results
suggested that Eß7 integrin, by
interacting with E-cadherin, mediates the adhesion between
CD8+ T lymphocytes and acinar epithelial cells in SS and
participates in inducing epithelial cell apoptosis, leading to
secretory dysfunction of exocrine glands, a hallmark of
SS.
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