HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ray, A. Articles by Ray, B. K. Search for Related Content PubMed PubMed Citation Articles by Ray, A. Articles by Ray, B. K.

Persistent Expression of Serum Amyloid A During Experimentally Induced Chronic Inflammatory Condition in Rabbit Involves Differential Activation of SAF, NF-B, and C/EBP Transcription Factors¹

Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211

The serum amyloid A (SAA) protein has been implicated in the pathogenesis of several chronic inflammatory diseases. Its induction mechanism in response to a chronic inflammatory condition was investigated in rabbits following multiple s.c. injections of AgNO₃ over a period of 35 days. During unremitting exposure to inflammatory stimulus, a persistently higher than normal level of SAA2 expression was seen in multiple tissues. Induction of SAA was correlated with higher levels of several transcription factor activities. Increased SAA-activating factor (SAF) activity was detected in the liver, lung, and brain tissues under both acute and chronic inflammatory conditions. In the heart, kidney, and skeletal muscle tissues, this activity remained virtually constant. In contrast, CCAAT enhancer binding protein (C/EBP) DNA-binding activity was transiently induced in selective tissues. Higher than normal NF-B DNA-binding activity was detected in the lung and to a lesser extent in the liver and kidney tissues under both acute and chronic conditions. This result suggested that C/EBP, SAF, and NF-B are required for transient acute phase induction of SAA whereas SAF and NF-B activities are necessary for persistent SAA expression during chronic inflammatory conditions.

This article has been cited by other articles:

				A. Ray, A. Shakya, D. Kumar, M. D. Benson, and B. K. Ray Inflammation-Responsive Transcription Factor SAF-1 Activity Is Linked to the Development of Amyloid A Amyloidosis J. Immunol., August 15, 2006; 177(4): 2601 - 2609. [Abstract] [Full Text] [PDF]

				A. Ray, D. Kumar, A. Shakya, C. R. Brown, J. L. Cook, and B. K. Ray Serum Amyloid A-Activating Factor-1 (SAF-1) Transgenic Mice Are Prone to Develop a Severe Form of Inflammation-Induced Arthritis J. Immunol., October 1, 2004; 173(7): 4684 - 4691. [Abstract] [Full Text] [PDF]

				A. Ray, A. Shakya, D. Kumar, and B. K. Ray Overexpression of Serum Amyloid A-Activating Factor 1 Inhibits Cell Proliferation by the Induction of Cyclin-Dependent Protein Kinase Inhibitor p21WAF-1/Cip-1/Sdi-1 Expression J. Immunol., April 15, 2004; 172(8): 5006 - 5015. [Abstract] [Full Text] [PDF]