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*
Rheumatology Division, Department of Medicine, Washington University School of Medicine, Howard Hughes Medical Institute, St. Louis, MO 63110; and
University of Western Australia, Nedlands, Western Australia, Australia
The Cmv1 locus controls NK cell-mediated
resistance to infection with murine CMV. Our recent genetic analysis of
backcross mice demonstrated that the NK gene complex (NKC)-linked
Cmv1 locus should reside between the Ly49
and Prp gene clusters on distal mouse chromosome 6. We
have aligned yeast artificial chromosome (YAC) inserts in a contig
spanning the interval between the Ly49 and
Prp gene clusters. This YAC contig includes 13
overlapping YAC inserts that span more than 2 megabases (Mb) in C57BL/6
(B6) mice. Since we have identified genomic clones that span the
Ly49-Prp gene region, we hypothesize that at least one
should contain the Cmv1 locus. To narrow the
Cmv1 critical region, we developed novel NKC genetic
markers and used these to genotype informative backcross and intra-NKC
recombinant congenic mouse DNA samples. These data suggest that
Cmv1 resides on a single YAC insert within an interval
that corresponds to a physical distance of 
390 kb. This high
resolution, integrated physical and genetic NKC map will facilitate
identification of Cmv1 and other NKC-linked loci that
regulate NK cell-mediated immunity.
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