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,§
*
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and
Department of Immunology and Medical Zoology and
§
Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan
TNF-related apoptosis-inducing ligand (TRAIL), a new member of TNF family, induces apoptotic cell death of various tumor cells. We recently showed that TRAIL mediates perforin- and Fas ligand (FasL)-independent cytotoxic activity of human CD4+ T cell clones. In the present study, we investigated the expression and function of TRAIL on murine lymphocytes by using newly generated anti-murine TRAIL mAbs. Although freshly isolated T, B, or NK cells did not express a detectable level of TRAIL on their surface, a remarkable level of TRAIL expression was induced preferentially on CD3- NK1.1+ NK cells after stimulation with IL-2 or IL-15. In contrast, TRAIL expression was not induced by IL-18, whereas it efficiently potentiated lymphokine-activated killer activity of NK cells. In addition to perforin inactivation and neutralization of FasL by anti-FasL mAb, neutralization of TRAIL by anti-TRAIL mAb was needed for the complete inhibition of IL-2- or IL-15-activated NK cell cytotoxicity against mouse fibrosarcoma L929 target cells, which were susceptible to both FasL and TRAIL. These results indicated preferential expression of TRAIL on IL-2- or IL-15-activated NK cells and its potential involvement in lymphokine-activated killer activity.
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M. Komatsu, M. Mammolenti, M. Jones, R. Jurecic, T. J. Sayers, and R. B. Levy Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing Blood, May 15, 2003; 101(10): 3991 - 3999. [Abstract] [Full Text] [PDF]
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H.-o. Lee, J. M. Herndon, R. Barreiro, T. S. Griffith, and T. A. Ferguson TRAIL: A Mechanism of Tumor Surveillance in an Immune Privileged Site J. Immunol., November 1, 2002; 169(9): 4739 - 4744. [Abstract] [Full Text] [PDF]
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D. Vermijlen, D. Luo, C. J Froelich, J. P. Medema, J. A. Kummer, E. Willems, F. Braet, and E. Wisse Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway J. Leukoc. Biol., October 1, 2002; 72(4): 668 - 676. [Abstract] [Full Text] [PDF]
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T. S. Soderstrom, M. Poukkula, T. H. Holmstrom, K. M. Heiskanen, and J. E. Eriksson Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8 J. Immunol., September 15, 2002; 169(6): 2851 - 2860. [Abstract] [Full Text] [PDF]
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 V. Poulaki, C. S. Mitsiades, V. Kotoula, S. Tseleni-Balafouta, A. Ashkenazi, D. A. Koutras, and N. Mitsiades Regulation of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Thyroid Carcinoma Cells Am. J. Pathol., August 1, 2002; 161(2): 643 - 654. [Abstract] [Full Text] [PDF]
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J. H. L. Velthuis, K. M. A. Rouschop, H. J. G. M. de Bont, G. J. Mulder, and J. F. Nagelkerke Distinct Intracellular Signaling in Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95 Ligand-mediated Apoptosis J. Biol. Chem., June 28, 2002; 277(27): 24631 - 24637. [Abstract] [Full Text] [PDF]
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N. Seki, A. D. Brooks, C. R. D. Carter, T. C. Back, E. M. Parsoneault, M. J. Smyth, R. H. Wiltrout, and T. J. Sayers Tumor-Specific CTL Kill Murine Renal Cancer Cells Using Both Perforin and Fas Ligand-Mediated Lysis In Vitro, But Cause Tumor Regression In Vivo in the Absence of Perforin J. Immunol., April 1, 2002; 168(7): 3484 - 3492. [Abstract] [Full Text] [PDF]
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E. Cretney, K. Takeda, H. Yagita, M. Glaccum, J. J. Peschon, and M. J. Smyth Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice J. Immunol., February 1, 2002; 168(3): 1356 - 1361. [Abstract] [Full Text] [PDF]
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K. Takeda, M. J. Smyth, E. Cretney, Y. Hayakawa, N. Kayagaki, H. Yagita, and K. Okumura Critical Role for Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development J. Exp. Med., January 14, 2002; 195(2): 161 - 169. [Abstract] [Full Text] [PDF]
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J. M. Routes, J. C. Ryan, S. Ryan, and M. Nakamura MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection Int. Immunol., October 1, 2001; 13(10): 1301 - 1307. [Abstract] [Full Text] [PDF]
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T. M. Baetu, H. Kwon, S. Sharma, N. Grandvaux, and J. Hiscott Disruption of NF-{kappa}B Signaling Reveals a Novel Role for NF-{kappa}B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression J. Immunol., September 15, 2001; 167(6): 3164 - 3173. [Abstract] [Full Text] [PDF]
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V. Screpanti, R. P. A. Wallin, H.-G. Ljunggren, and A. Grandien A Central Role for Death Receptor-Mediated Apoptosis in the Rejection of Tumors by NK Cells J. Immunol., August 15, 2001; 167(4): 2068 - 2073. [Abstract] [Full Text] [PDF]
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M. L. Jelachich and H. L. Lipton Theiler's Murine Encephalomyelitis Virus Induces Apoptosis in Gamma Interferon-Activated M1 Differentiated Myelomonocytic Cells through a Mechanism Involving Tumor Necrosis Factor Alpha (TNF-{alpha}) and TNF-{alpha}-Related Apoptosis-Inducing Ligand J. Virol., July 1, 2001; 75(13): 5930 - 5938. [Abstract] [Full Text] [PDF]
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 X. F. Li, D. S. Charnock-Jones, E. Zhang, S. Hiby, S. Malik, K. Day, D. Licence, J. M. Bowen, L. Gardner, A. King, et al. Angiogenic Growth Factor Messenger Ribonucleic Acids in Uterine Natural Killer Cells J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1823 - 1834. [Abstract] [Full Text]
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M. Nieda, A. Nicol, Y. Koezuka, A. Kikuchi, N. Lapteva, Y. Tanaka, K. Tokunaga, K. Suzuki, N. Kayagaki, H. Yagita, et al. TRAIL expression by activated human CD4+V{alpha}24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells Blood, April 1, 2001; 97(7): 2067 - 2074. [Abstract] [Full Text] [PDF]
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M. J. Smyth, E. Cretney, K. Takeda, R. H. Wiltrout, L. M. Sedger, N. Kayagaki, H. Yagita, and K. Okumura Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Contributes to Interferon {{gamma}}-dependent Natural Killer Cell Protection from Tumor Metastasis J. Exp. Med., March 12, 2001; 193(6): 661 - 670. [Abstract] [Full Text] [PDF]
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B. Hilliard, A. Wilmen, C. Seidel, T.-S. T. Liu, R. Goke, and Y. Chen Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis J. Immunol., January 15, 2001; 166(2): 1314 - 1319. [Abstract] [Full Text] [PDF]
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M. Nakayama, N. Kayagaki, N. Yamaguchi, K. Okumura, and H. Yagita Involvement of TWEAK in Interferon {gamma}-stimulated Monocyte Cytotoxicity J. Exp. Med., November 6, 2000; 192(9): 1373 - 1380. [Abstract] [Full Text] [PDF]
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B. Trinite, C. Voisine, H. Yagita, and R. Josien A Subset of Cytolytic Dendritic Cells in Rat J. Immunol., October 15, 2000; 165(8): 4202 - 4208. [Abstract] [Full Text] [PDF]
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T. J. Sayers, A. D. Brooks, N. Seki, M. J. Smyth, H. Yagita, B. R. Blazar, and A. M. Malyguine T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas J. Leukoc. Biol., July 1, 2000; 68(1): 81 - 86. [Abstract] [Full Text]
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