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CUTTING EDGE |
*
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, and
Intramural Research Support Program, Science Applications International Corp.-Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702
Although CD34+ progenitor-derived immature dendritic
cells (DCs) express CCR6, several recent studies reported that
monocyte-derived immature DCs do not do so. We observed that DCs
generated from monocytes in the presence of GM-CSF, IL-4, and TGF-ß1
consistently responded to liver and activation-regulated chemokine
(LARC, also known as macrophage inflammatory protein-3
). These
immature DCs expressed one class of high-affinity binding sites for
LARC, and expressed both CCR6 mRNA and protein. Therefore, LARC-CCR6
interaction presumably also contributes to the regulation of
trafficking of monocyte-derived DCs, and utilization of TGF-ß can
potentially provide a ready source of CCR6+
monocyte-derived DCs for therapeutic purposes.
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K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi TGF-{beta}1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors J. Immunol., March 1, 2000; 164(5): 2285 - 2295. [Abstract] [Full Text] [PDF]
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