| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Neurocrine Biosciences Inc., San Diego, CA 92121; and
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Molecular analyses of the chemokine fractalkine and its receptor
CX3C-R1 in the rat brain have revealed a striking
polarization: fractalkine is expressed constitutively in neurons and is
up-regulated by TNF-
and IL-1
in astrocytes. Expression of its
specific receptor, CX3C-R1, is restricted to astrocytes and
microglia. We have analyzed the functional correlates of this
expression and demonstrate that fractalkine induces microglial cell
migration and activation. However, the activity of this chemokine on
astrocytes may also be highly relevant in inducing astrocyte-microglia
cell interactions through cytokine/mediator release leading to
microglial activation.
This article has been cited by other articles:
|
|
 |
|
  Y. Ishida, T. Hayashi, T. Goto, A. Kimura, S. Akimoto, N. Mukaida, and T. Kondo Essential Involvement of CX3CR1-Mediated Signals in the Bactericidal Host Defense during Septic Peritonitis J. Immunol., September 15, 2008; 181(6): 4208 - 4218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lauro, S. Di Angelantonio, R. Cipriani, F. Sobrero, L. Antonilli, V. Brusadin, D. Ragozzino, and C. Limatola Activity of Adenosine Receptors Type 1 Is Required for CX3CL1-Mediated Neuroprotection and Neuromodulation in Hippocampal Neurons J. Immunol., June 1, 2008; 180(11): 7590 - 7596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Mizutani, T. Sakurai, T. Shibata, K. Uchida, J. Fujita, R. Kawashima, Y. I. Kawamura, N. Toyama-Sorimachi, T. Imai, and T. Dohi Dose-Dependent Differential Regulation of Cytokine Secretion from Macrophages by Fractalkine J. Immunol., December 1, 2007; 179(11): 7478 - 7487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lauro, M. Catalano, F. Trettel, F. Mainiero, M. T. Ciotti, F. Eusebi, and C. Limatola The Chemokine CX3CL1 Reduces Migration and Increases Adhesion of Neurons with Mechanisms Dependent on the beta1 Integrin Subunit J. Immunol., December 1, 2006; 177(11): 7599 - 7606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saraswathy, G. Wu, and N. A. Rao Retinal microglial activation and chemotaxis by docosahexaenoic Acid hydroperoxide. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3656 - 3663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Davis and J. K. Harrison Proline 326 in the C Terminus of Murine CX3CR1 Prevents G-Protein and Phosphatidylinositol 3-Kinase-Dependent Stimulation of Akt and Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells J. Pharmacol. Exp. Ther., January 1, 2006; 316(1): 356 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Gevrey, B. M. Isaac, and D. Cox Syk Is Required for Monocyte/Macrophage Chemotaxis to CX3CL1 (Fractalkine) J. Immunol., September 15, 2005; 175(6): 3737 - 3745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Carbonell, S.-I. Murase, A. F. Horwitz, and J. W. Mandell Migration of Perilesional Microglia after Focal Brain Injury and Modulation by CC Chemokine Receptor 5: An In Situ Time-Lapse Confocal Imaging Study J. Neurosci., July 27, 2005; 25(30): 7040 - 7047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Sukkar, R. Issa, S. Xie, U. Oltmanns, R. Newton, and K. F. Chung Fractalkine/CX3CL1 production by human airway smooth muscle cells: induction by IFN-{gamma} and TNF-{alpha} and regulation by TGF-{beta} and corticosteroids Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1230 - L1240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Rock, G. Gekker, S. Hu, W. S. Sheng, M. Cheeran, J. R. Lokensgard, and P. K. Peterson Role of Microglia in Central Nervous System Infections Clin. Microbiol. Rev., October 1, 2004; 17(4): 942 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Daoudi, E. Lavergne, A. Garin, N. Tarantino, P. Debre, F. Pincet, C. Combadiere, and P. Deterre Enhanced Adhesive Capacities of the Naturally Occurring Ile249-Met280 Variant of the Chemokine Receptor CX3CR1 J. Biol. Chem., May 7, 2004; 279(19): 19649 - 19657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Ji, B. P. He, S. T. Dheen, and S. S. W. Tay Interactions of Chemokines and Chemokine Receptors Mediate the Migration of Mesenchymal Stem Cells to the Impaired Site in the Brain After Hypoglossal Nerve Injury Stem Cells, May 1, 2004; 22(3): 415 - 427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vitale, A. Schmid-Alliana, V. Breuil, M. Pomeranz, M.-A. Millet, B. Rossi, and H. Schmid-Antomarchi Soluble Fractalkine Prevents Monocyte Chemoattractant Protein-1-Induced Monocyte Migration via Inhibition of Stress-Activated Protein Kinase 2/p38 and Matrix Metalloproteinase Activities J. Immunol., January 1, 2004; 172(1): 585 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Habasque, A.-P. Satie, F. Aubry, B. Jegou, and M. Samson Expression of fractalkine in the rat testis: molecular cloning of a novel alternative transcript of its gene that is differentially regulated by pro-inflammatory cytokines Mol. Hum. Reprod., August 1, 2003; 9(8): 449 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Tripp, A. Dakhama, L. P. Jones, A. Barskey, E. W. Gelfand, and L. J. Anderson The G Glycoprotein of Respiratory Syncytial Virus Depresses Respiratory Rates through the CX3C Motif and Substance P J. Virol., June 1, 2003; 77(11): 6580 - 6584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Harada, C. Harada, S. Kohsaka, E. Wada, K. Yoshida, S. Ohno, H. Mamada, K. Tanaka, L. F. Parada, and K. Wada Microglia-Muller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration J. Neurosci., November 1, 2002; 22(21): 9228 - 9236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Fong, S. M. Alam, T. Imai, B. Haribabu, and D. D. Patel CX3CR1 Tyrosine Sulfation Enhances Fractalkine-induced Cell Adhesion J. Biol. Chem., May 24, 2002; 277(22): 19418 - 19423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fujimoto, T. Imaizumi, H. Yoshida, S. Takanashi, K. Okumura, and K. Satoh Interferon-gamma Stimulates Fractalkine Expression in Human Bronchial Epithelial Cells and Regulates Mononuclear Cell Adherence Am. J. Respir. Cell Mol. Biol., August 1, 2001; 25(2): 233 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Cook, S.-C. Chen, L. M. Sullivan, D. J. Manfra, M. T. Wiekowski, D. M. Prosser, G. Vassileva, and S. A. Lira Generation and Analysis of Mice Lacking the Chemokine Fractalkine Mol. Cell. Biol., May 1, 2001; 21(9): 3159 - 3165. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Robinson, C. Nataraj, D. W. Thomas, D. N. Howell, R. Griffiths, V. Bautch, D. D. Patel, L. Feng, and T. M. Coffman A Role for Fractalkine and Its Receptor (CX3CR1) in Cardiac Allograft Rejection J. Immunol., December 1, 2000; 165(11): 6067 - 6072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sauder, W. Hallensleben, A. Pagenstecher, S. Schneckenburger, L. Biro, D. Pertlik, J. Hausmann, M. Suter, and P. Staeheli Chemokine Gene Expression in Astrocytes of Borna Disease Virus-Infected Rats and Mice in the Absence of Inflammation J. Virol., October 1, 2000; 74(19): 9267 - 9280. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Boehme, F. M. Lio, D. Maciejewski-Lenoir, K. B. Bacon, and P. J. Conlon The Chemokine Fractalkine Inhibits Fas-Mediated Cell Death of Brain Microglia J. Immunol., July 1, 2000; 165(1): 397 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Fong, H. P. Erickson, J. P. Zachariah, S. Poon, N. J. Schamberg, T. Imai, and D. D. Patel Ultrastructure and Function of the Fractalkine Mucin Domain in CX3C Chemokine Domain Presentation J. Biol. Chem., February 11, 2000; 275(6): 3781 - 3786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kansra, C. Groves, J. C. Gutierrez-Ramos, and R. D. Polakiewicz Phosphatidylinositol 3-Kinase-dependent Extracellular Calcium Influx Is Essential for CX3CR1-mediated Activation of the Mitogen-activated Protein Kinase Cascade J. Biol. Chem., August 17, 2001; 276(34): 31831 - 31838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Mizoue, S. K. Sullivan, D. S. King, T. N. Kledal, T. W. Schwartz, K. B. Bacon, and T. M. Handel Molecular Determinants of Receptor Binding and Signaling by the CX3C Chemokine Fractalkine J. Biol. Chem., August 31, 2001; 276(36): 33906 - 33914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Meucci, A. Fatatis, A. A. Simen, and R. J. Miller Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival PNAS, July 5, 2000; 97(14): 8075 - 8080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Chapman, K. Moores, D. Harrison, C. A. Campbell, B. R. Stewart, and P. J. L. M. Strijbos Fractalkine Cleavage from Neuronal Membranes Represents an Acute Event in the Inflammatory Response to Excitotoxic Brain Damage J. Neurosci., August 1, 2000; 20(15): RC87 - RC87. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
