|
|
||||||||
Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
The IFN-stimulated response element (ISRE) is an important
conserved cis-acting regulatory element in the promoter
of MHC class I genes, but displays considerable locus-specific
nucleotide variation. In this report, the putative ISREs of classical
and nonclassical HLA class I genes were investigated for their
contribution to MHC class I transactivation. It is shown that IFN-
induced MHC class I transactivation through the ISRE of HLA-A, HLA-B,
HLA-C, and HLA-F. This is congruent with the binding of IFN regulatory
factor-1 to the ISREs of these loci upon IFN-
treatment. Sp1 was
shown to bind to the CG-rich sequences in the ISRE regions of HLA-B,
HLA-C, and HLA-G. The putative E box 5' of the ISRE in most HLA-B
alleles was shown to bind the upstream stimulatory factors (USF) 1 and
2. The Sp1 and USF binding sites did not influence IFN-
-induced
transactivation. However, the USF binding site played a suppressive
role in the constitutive expression of HLA-B. The locus-specific
transcriptional control through the ISRE could be an important
mechanism in the differential regulation of classical and nonclassical
MHC class I expression, which determines adequate Ag presentation upon
pathogenic challenge.
This article has been cited by other articles:
![]() |
A. S. Kotekar, J. D. Weissman, A. Gegonne, H. Cohen, and D. S. Singer Histone Modifications, but Not Nucleosomal Positioning, Correlate with Major Histocompatibility Complex Class I Promoter Activity in Different Tissues In Vivo Mol. Cell. Biol., December 15, 2008; 28(24): 7323 - 7336. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Liu, L. Ye, Y. Bai, H. Mojidi, N. E. Simister, and X. Zhu Activation of the JAK/STAT-1 Signaling Pathway by IFN-{gamma} Can Down-Regulate Functional Expression of the MHC Class I-Related Neonatal Fc Receptor for IgG J. Immunol., July 1, 2008; 181(1): 449 - 463. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. M. Doody, S. Stephenson, C. McManamy, and R. M. Tooze PRDM1/BLIMP-1 Modulates IFN-{gamma}-Dependent Control of the MHC Class I Antigen-Processing and Peptide-Loading Pathway J. Immunol., December 1, 2007; 179(11): 7614 - 7623. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Christova, T. Jones, P.-J. Wu, A. Bolzer, A. P. Costa-Pereira, D. Watling, I. M. Kerr, and D. Sheer P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFN{gamma} J. Cell Sci., September 15, 2007; 120(18): 3262 - 3270. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Sekimoto, S. Ozaki, T. Ohshima, H. Shibata, T. Hashimoto, M. Abe, N. Kimura, K. Hattori, S. Kawai, Y. Kinoshita, et al. A Single-Chain Fv Diabody against Human Leukocyte Antigen-A Molecules Specifically Induces Myeloma Cell Death in the Bone Marrow Environment Cancer Res., February 1, 2007; 67(3): 1184 - 1192. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Browne, J. R. Roesser, S. Z. Zhu, and G. D. Ginder Differential IFN-{gamma} Stimulation of HLA-A Gene Expression through CRM-1-Dependent Nuclear RNA Export J. Immunol., December 15, 2006; 177(12): 8612 - 8619. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Moon, S. M. Veniamin, J. A. Parks-Dely, and K. E. Magor The MHC of the Duck (Anas platyrhynchos) Contains Five Differentially Expressed Class I Genes J. Immunol., November 15, 2005; 175(10): 6702 - 6712. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Rempel, L. A. Quina, P. K. Blakely-Gonzales, M. J. Buchmeier, and D. L. Gruol Viral Induction of Central Nervous System Innate Immune Responses J. Virol., April 1, 2005; 79(7): 4369 - 4381. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. K. Howcroft, J. D. Weissman, A. Gegonne, and D. S. Singer A T Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression J. Immunol., February 15, 2005; 174(4): 2106 - 2115. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. P. Gobin, P. Biesta, and P. J. Van den Elsen Regulation of human beta 2-microglobulin transactivation in hematopoietic cells Blood, April 15, 2003; 101(8): 3058 - 3064. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. R. Johnson Locus-Specific Constitutive and Cytokine-Induced HLA Class I Gene Expression J. Immunol., February 15, 2003; 170(4): 1894 - 1902. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Moreau, G. Mouillot, P. Rousseau, C. Marcou, J. Dausset, and E. D. Carosella HLA-G gene repression is reversed by demethylation PNAS, February 4, 2003; 100(3): 1191 - 1196. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. P. Gobin, P. Biesta, J. E. M. de Steenwinkel, G. Datema, and P. J. Van den Elsen HLA-G Transactivation by cAMP-response Element-binding Protein (CREB). AN ALTERNATIVE TRANSACTIVATION PATHWAY TO THE CONSERVED MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I REGULATORY ROUTES J. Biol. Chem., October 11, 2002; 277(42): 39525 - 39531. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Xu, D. Ye, M. Fisher, and R. L. Juliano Selective Inhibition of P-glycoprotein Expression in Multidrug-Resistant Tumor Cells by a Designed Transcriptional Regulator J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 963 - 971. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. P. Gobin, M. van Zutphen, S. D. Westerheide, J. M. Boss, and P. J. van den Elsen The MHC-Specific Enhanceosome and Its Role in MHC Class I and {beta}2-Microglobulin Gene Transactivation J. Immunol., November 1, 2001; 167(9): 5175 - 5184. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. E. Luker, C. M. Pica, R. D. Schreiber, and D. Piwnica-Worms Overexpression of IRF9 Confers Resistance to Antimicrotubule Agents in Breast Cancer Cells Cancer Res., September 1, 2001; 61(17): 6540 - 6547. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Arons, V. Kunin, C. Schechter, and R. Ehrlich Organization and Functional Analysis of the Mouse Transporter Associated with Antigen Processing 2 Promoter J. Immunol., March 15, 2001; 166(6): 3942 - 3951. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. P. Gobin, P. J. van den Elsen, and J. Girdlestone Locus-specific regulation of HLA-A and HLA-B expression is not determined by nucleotide variation in the X2 box promoter element Blood, March 1, 2001; 97(5): 1518 - 1521. [Full Text] [PDF] |
||||
![]() |
S. Lefebvre, S. Berrih-Aknin, F. Adrian, P. Moreau, S. Poea, L. Gourand, J. Dausset, E. D. Carosella, and P. Paul A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-beta J. Biol. Chem., February 23, 2001; 276(9): 6133 - 6139. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |