| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology and Microbiology, Wayne State University, Detroit MI 48201
Regulation of the immune response is critical to homeostasis. While
innate immunity can influence the development of adaptive immune
responses, its role in regulation is less well understood. Recently, NK
cells have been implicated in the control of experimental autoimmune
encephalomyelitis, an animal model for multiple sclerosis. In this
report, we show that rat bone marrow-derived NK cells exhibited potent
inhibitory effects on T cell proliferation to both Con A as well as the
central nervous system Ag myelin basic protein. There was also a
significant decrease in both IFN-
and IL-10 production in vitro,
whereas levels of the 
-chemokine monocyte chemoattractant protein-1
were significantly elevated. Flow cytometry studies suggest that the NK
cells may play an important role in regulating both normal and
autoimmune T cell responses by exerting a direct effect on activated,
autoantigen-specific T cells.
This article has been cited by other articles:
|
|
 |
|
  G. Chen, G. Han, J. Wang, R. Wang, R. Xu, B. Shen, J. Qian, and Y. Li Natural Killer Cells Modulate Overt Autoimmunity to Homeostasis in Nonobese Diabetic Mice after Anti-CD3 F(ab')2 Antibody Treatment through Secreting Transforming Growth Factor-{beta} Am. J. Pathol., September 1, 2009; 175(3): 1086 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kheradmand, P. P. Trivedi, N. A. Wolf, P. C. Roberts, and R. H. Swanborg Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats J. Leukoc. Biol., May 1, 2008; 83(5): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Liu, L. V. Kaer, A. L. Cava, M. Price, D. I. Campagnolo, M. Collins, D. A. Young, T. L. Vollmer, and F.-D. Shi Autoreactive T Cells Mediate NK Cell Degeneration in Autoimmune Disease J. Immunol., May 1, 2006; 176(9): 5247 - 5254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bielekova, M. Catalfamo, S. Reichert-Scrivner, A. Packer, M. Cerna, T. A. Waldmann, H. McFarland, P. A. Henkart, and R. Martin Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2R{alpha}-targeted therapy (daclizumab) in multiple sclerosis PNAS, April 11, 2006; 103(15): 5941 - 5946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Trivedi, P. C. Roberts, N. A. Wolf, and R. H. Swanborg NK Cells Inhibit T Cell Proliferation via p21-Mediated Cell Cycle Arrest J. Immunol., April 15, 2005; 174(8): 4590 - 4597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takahashi, T. Aranami, M. Endoh, S. Miyake, and T. Yamamura The regulatory role of natural killer cells in multiple sclerosis Brain, September 1, 2004; 127(9): 1917 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pridgeon, G. P. Lennon, L. Pazmany, R. N. Thompson, S. E. Christmas, and R. J. Moots Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype Rheumatology, July 1, 2003; 42(7): 870 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-X. Zhang, H. Xu, M. Kishi, D. Calida, and A. Rostami The Role of IL-12 in the Induction of Intravenous Tolerance in Experimental Autoimmune Encephalomyelitis J. Immunol., March 1, 2002; 168(5): 2501 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. O'Sullivan, C. A. Skandera, and P. C. Montgomery Lymphocyte Lineages at Mucosal Effector Sites: Rat Salivary Glands J. Immunol., May 1, 2001; 166(9): 5522 - 5529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Huang, J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis J. Exp. Med., March 19, 2001; 193(6): 713 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Goodier and M. Londei Lipopolysaccharide Stimulates the Proliferation of Human CD56+CD3- NK Cells: A Regulatory Role of Monocytes and IL-10 J. Immunol., July 1, 2000; 165(1): 139 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G X Zhang, C M Baker, D L Kolson, and A M Rostami Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis Multiple Sclerosis, February 1, 2000; 6(1): 3 - 13. [Abstract] [PDF]
|
|
|
|
|
|
D. C. Lenz, N. A. Wolf, and R. H. Swanborg Strain Variation in Autoimmunity: Attempted Tolerization of DA Rats Results in the Induction of Experimental Autoimmune Encephalomyelitis J. Immunol., August 15, 1999; 163(4): 1763 - 1768. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
