HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nayak, B. P. Articles by Rao, K. V. S. Search for Related Content PubMed PubMed Citation Articles by Nayak, B. P. Articles by Rao, K. V. S.

B Cell Responses to a Peptide Epitope. VIII. Immune Complex-Mediated Regulation of Memory B Cell Generation Within Germinal Centers¹

Immunology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India

Using an in vivo reconstitution assay, we examine here the role of immune complexes in both formation of germinal centers (GC) and processes that occur subsequently within. The presence of Ag, as immune complexes, was found not to constitute a limiting requirement for the initiation of GC formation. No detrimental effect either on numbers or sizes of the resulting GC was observed when Ag-containing immune complexes were omitted during reconstitution. Thus, both recruitment and proliferation of Ag-activated B cells within GC appear not to be limited by Ag concentrations. In contrast, the presence of immune complexes was observed to be obligatory for the generation of Ag-specific memory B cells. This optimally required immune complexes to be constituted by IgG-class Abs with epitope specificities that were homologous to those of the GC B cells. The GC reaction was also found to be characterized by an enhancement of Ab specificity for the homologous epitope. Although some improvement in specificity was noted in recall responses from immune complex-deficient GC, the presence of appropriate immune complexes served to further optimize the outcome. Here again, isotype and epitope-specificity of the Ab constituent in immune complexes proved to be important.

This article has been cited by other articles:

				J. S. Moreira and J. Faro Modelling Two Possible Mechanisms for the Regulation of the Germinal Center Dynamics J. Immunol., September 15, 2006; 177(6): 3705 - 3710. [Abstract] [Full Text] [PDF]

				L. J. Brady Antibody-Mediated Immunomodulation: a Strategy To Improve Host Responses against Microbial Antigens Infect. Immun., February 1, 2005; 73(2): 671 - 678. [Full Text] [PDF]

				D. T. Nair, K. Singh, N. Sahu, K. V. S. Rao, and D. M. Salunke Crystal Structure of an Antibody Bound to an Immunodominant Peptide Epitope: Novel Features in Peptide-Antibody Recognition J. Immunol., December 15, 2000; 165(12): 6949 - 6955. [Abstract] [Full Text] [PDF]

				A. Corcoran, S. Doyle, D. Waldron, A. Nicholson, and B. P. Mahon Impaired Gamma Interferon Responses against Parvovirus B19 by Recently Infected Children J. Virol., November 1, 2000; 74(21): 9903 - 9910. [Abstract] [Full Text]

				X. Wu, N. Jiang, Y.-F. Fang, C. Xu, D. Mao, J. Singh, Y.-X. Fu, and H. Molina Impaired Affinity Maturation in Cr2-/- Mice Is Rescued by Adjuvants Without Improvement in Germinal Center Development J. Immunol., September 15, 2000; 165(6): 3119 - 3127. [Abstract] [Full Text] [PDF]

				P. Nakra, V. Manivel, R. A. Vishwakarma, and K. V. S. Rao B Cell Responses to a Peptide Epitope. X. Epitope Selection in a Primary Response Is Thermodynamically Regulated J. Immunol., June 1, 2000; 164(11): 5615 - 5625. [Abstract] [Full Text] [PDF]