The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Segel, L. A.
Right arrow Articles by Bar-Or, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Segel, L. A.
Right arrow Articles by Bar-Or, R. L.
The Journal of Immunology, 1999, 163: 1342-1349.
Copyright © 1999 by The American Association of Immunologists

On the Role of Feedback in Promoting Conflicting Goals of the Adaptive Immune System1

Lee A. Segel2 and Ruth Lev Bar-Or

Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel

We explored here the implications of two premises. 1) In their response over days or weeks to pathogen invasion, cells of the immune system combine several overlapping and perhaps contradictory goals. 2) The immune system has ways to monitor progress toward these goals via receptors that bind chemicals whose concentrations are related to such progress. We illustrate with simple mathematical models how such monitoring can lead to feedbacks that improve the efficiency of a given effector type in accomplishing its specialized task, and also how feedbacks can shift the balance among a variety of effectors toward a preponderance of the more effective. Specific suggestions are given for feedback molecules.




This article has been cited by other articles:


Home page
 Int ImmunolHome page
M. Cohn
What roles do regulatory T cells play in the control of the adaptive immune response?
Int. Immunol., September 1, 2008; 20(9): 1107 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
L. Mendes, T. Piersma, D. Hasselquist, K. D. Matson, and R. E. Ricklefs
Variation in the innate and acquired arms of the immune system among five shorebird species
J. Exp. Biol., January 15, 2006; 209(2): 284 - 291.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. A. M. Borghans and R. J. De Boer
Memorizing innate instructions requires a sufficiently specific adaptive immune system
Int. Immunol., May 1, 2002; 14(5): 525 - 532.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. D. W. Frost, M.-J. Dumaurier, S. Wain-Hobson, and A. J. L. Brown
Genetic drift and within-host metapopulation dynamics of HIV-1 infection
PNAS, May 24, 2001; (2001) 131056998.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. R. Levin and R. Antia
Why We Don't Get Sick: The Within-Host Population Dynamics of Bacterial Infections
Science, May 11, 2001; 292(5519): 1112 - 1115.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. E. Wigginton and D. Kirschner
A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis
J. Immunol., February 1, 2001; 166(3): 1951 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. D. W. Frost, M.-J. Dumaurier, S. Wain-Hobson, and A. J. L. Brown
Genetic drift and within-host metapopulation dynamics of HIV-1 infection
PNAS, June 5, 2001; 98(12): 6975 - 6980.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.