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*
Departamento de Bioquímica y Biología Molecular y Cellular, Facultad de Ciencias, and
Servicio de Inmunología, Hospital Clínico Universitario, Universidad de Zaragoza, Zaragoza, Spain
Activation-induced cell death is a process by which overactivated T
cells are eliminated, thus preventing potential autoimmune attacks. Two
known mediators of activation-induced cell death are Fas(CD95) ligand
(FasL) and APO2 ligand (APO2L)/TNF-related apoptosis-inducing ligand
(TRAIL). We show here that upon mitogenic stimulation, bioactive FasL
and APO2L are released from the T cell leukemia Jurkat and from normal
human T cell blasts as intact, nonproteolyzed proteins associated with
a particulate, ultracentrifugable fraction. We have characterized this
fraction as microvesicles of 100–200 nm in diameter. These
microvesicles are released from Jurkat and T cell blasts shortly (
1
h) after PHA stimulation, well before the cell enters apoptosis. FasL-
and APO2L-containing vesicles are also present in supernatants from
PHA-activated fresh human PBMC. These observations provide the basis
for a new and efficient mechanism for the rapid induction of autocrine
or paracrine cell death during immune
regulation.
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D. Siegmund, A. Hausser, N. Peters, P. Scheurich, and H. Wajant Tumor Necrosis Factor (TNF) and Phorbol Ester Induce TNF-related Apoptosis-inducing Ligand (TRAIL) under Critical Involvement of NF-kappa B Essential Modulator (NEMO)/IKKgamma J. Biol. Chem., November 16, 2001; 276(47): 43708 - 43712. [Abstract] [Full Text] [PDF]
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S. Jodo, S. Xiao, A. Hohlbaum, D. Strehlow, A. Marshak-Rothstein, and S.-T. Ju Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES J. Biol. Chem., October 19, 2001; 276(43): 39938 - 39944. [Abstract] [Full Text] [PDF]
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P. Secchiero, P. Mirandola, D. Zella, C. Celeghini, A. Gonelli, M. Vitale, S. Capitani, and G. Zauli Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4+ T cells Blood, October 15, 2001; 98(8): 2474 - 2481. [Abstract] [Full Text] [PDF]
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T. M. Baetu, H. Kwon, S. Sharma, N. Grandvaux, and J. Hiscott Disruption of NF-{kappa}B Signaling Reveals a Novel Role for NF-{kappa}B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression J. Immunol., September 15, 2001; 167(6): 3164 - 3173. [Abstract] [Full Text] [PDF]
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A. Renz, W. E. Berdel, M. Kreuter, C. Belka, K. Schulze-Osthoff, and M. Los Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo Blood, September 1, 2001; 98(5): 1542 - 1548. [Abstract] [Full Text] [PDF]
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R. Di Pietro, P. Secchiero, R. Rana, D. Gibellini, G. Visani, K. Bemis, L. Zamai, S. Miscia, and G. Zauli Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1 Blood, May 1, 2001; 97(9): 2596 - 2603. [Abstract] [Full Text] [PDF]
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Y. Miura, N. Misawa, N. Maeda, Y. Inagaki, Y. Tanaka, M. Ito, N. Kayagaki, N. Yamamoto, H. Yagita, H. Mizusawa, et al. Critical Contribution of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) to Apoptosis of Human CD4+ T Cells in HIV-1-infected hu-PBL-NOD-SCID Mice J. Exp. Med., March 5, 2001; 193(5): 651 - 660. [Abstract] [Full Text] [PDF]
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 A. D'Alessio, A. Riccioli, P. Lauretti, F. Padula, B. Muciaccia, P. De Cesaris, A. Filippini, S. Nagata, and E. Ziparo Testicular FasL is expressed by sperm cells PNAS, February 22, 2001; (2001) 51566098. [Abstract] [Full Text]
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S. Jodo, A. M. Hohlbaum, S. Xiao, D. Chan, D. Strehlow, D. H. Sherr, A. Marshak-Rothstein, and S.-T. Ju CD95 (Fas) Ligand-Expressing Vesicles Display Antibody-Mediated, FcR-Dependent Enhancement of Cytotoxicity J. Immunol., November 15, 2000; 165(10): 5487 - 5494. [Abstract] [Full Text] [PDF]
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M. Austin Taylor, M. Bennett, V. Kumar, and J. D. Schatzle Functional Defects of NK Cells Treated with Chloroquine Mimic the Lytic Defects Observed in Perforin-Deficient Mice J. Immunol., November 1, 2000; 165(9): 5048 - 5053. [Abstract] [Full Text] [PDF]
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C. Traidl, S. Sebastiani, C. Albanesi, H. F. Merk, P. Puddu, G. Girolomoni, and A. Cavani Disparate Cytotoxic Activity of Nickel-Specific CD8+ and CD4+ T Cell Subsets Against Keratinocytes J. Immunol., September 15, 2000; 165(6): 3058 - 3064. [Abstract] [Full Text] [PDF]
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L. Zamai, P. Secchiero, S. Pierpaoli, A. Bassini, S. Papa, E. S. Alnemri, L. Guidotti, M. Vitale, and G. Zauli TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis Blood, June 15, 2000; 95(12): 3716 - 3724. [Abstract] [Full Text] [PDF]
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S. Jodo, D. Strehlow, and S.-T. Ju Bioactivities of Fas Ligand-Expressing Retroviral Particles J. Immunol., May 15, 2000; 164(10): 5062 - 5069. [Abstract] [Full Text] [PDF]
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E. S. Bergmann-Leitner and S. I. Abrams Differential Role of Fas/Fas Ligand Interactions in Cytolysis of Primary and Metastatic Colon Carcinoma Cell Lines by Human Antigen-Specific CD8+ CTL J. Immunol., May 1, 2000; 164(9): 4941 - 4954. [Abstract] [Full Text] [PDF]
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A. D'Alessio, A. Riccioli, P. Lauretti, F. Padula, B. Muciaccia, P. De Cesaris, A. Filippini, S. Nagata, and E. Ziparo Testicular FasL is expressed by sperm cells PNAS, March 13, 2001; 98(6): 3316 - 3321. [Abstract] [Full Text] [PDF]
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