| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Departamento de Bioquímica y Biología Molecular y Cellular, Facultad de Ciencias, and
Servicio de Inmunología, Hospital Clínico Universitario, Universidad de Zaragoza, Zaragoza, Spain
Activation-induced cell death is a process by which overactivated T
cells are eliminated, thus preventing potential autoimmune attacks. Two
known mediators of activation-induced cell death are Fas(CD95) ligand
(FasL) and APO2 ligand (APO2L)/TNF-related apoptosis-inducing ligand
(TRAIL). We show here that upon mitogenic stimulation, bioactive FasL
and APO2L are released from the T cell leukemia Jurkat and from normal
human T cell blasts as intact, nonproteolyzed proteins associated with
a particulate, ultracentrifugable fraction. We have characterized this
fraction as microvesicles of 100–200 nm in diameter. These
microvesicles are released from Jurkat and T cell blasts shortly (
1
h) after PHA stimulation, well before the cell enters apoptosis. FasL-
and APO2L-containing vesicles are also present in supernatants from
PHA-activated fresh human PBMC. These observations provide the basis
for a new and efficient mechanism for the rapid induction of autocrine
or paracrine cell death during immune
regulation.
This article has been cited by other articles:
|
|
 |
|
  E. U. Wieckowski, C. Visus, M. Szajnik, M. J. Szczepanski, W. J. Storkus, and T. L. Whiteside Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes J. Immunol., September 15, 2009; 183(6): 3720 - 3730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. O'Brien, M. A. Richardson, S. F. Mehrbod, D. T. Berg, B. Gerlitz, A. Gupta, and B. W. Grinnell Activated Protein C Decreases Tumor Necrosis Factor Related Apoptosis-Inducing Ligand by an EPCR- Independent Mechanism Involving Egr-1/Erk-1/2 Activation Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2634 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Locklin, E. Federici, B. Espina, P. A. Hulley, R. G. G. Russell, and C. M. Edwards Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis Mol. Cancer Ther., December 1, 2007; 6(12): 3219 - 3228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lin, W. Wei, J. Zhang, S. Liu, Y. Liu, and D. Zheng Formyl peptide receptor-like 1 mediated endogenous TRAIL gene expression with tumoricidal activity Mol. Cancer Ther., October 1, 2007; 6(10): 2618 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Kim, N. R. Bianco, W. J. Shufesky, A. E. Morelli, and P. D. Robbins MHC Class II+ Exosomes in Plasma Suppress Inflammation in an Antigen-Specific and Fas Ligand/Fas-Dependent Manner J. Immunol., August 15, 2007; 179(4): 2235 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bosque, J. I. Aguilo, M. A. Alava, E. Paz-Artal, J. Naval, L. M. Allende, and A. Anel The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling Blood, February 15, 2007; 109(4): 1627 - 1635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. O'Hara, A. J. Small, J. B. Nelson, A. D. Badley, X.-M. Chen, G. J. Gores, and N. F. LaRusso The Human Immunodeficiency Virus Type 1 Tat Protein Enhances Cryptosporidium parvum-Induced Apoptosis in Cholangiocytes via a Fas Ligand-Dependent Mechanism Infect. Immun., February 1, 2007; 75(2): 684 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zuccato, E. J. Blott, O. Holt, S. Sigismund, M. Shaw, G. Bossi, and G. M. Griffiths Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation J. Cell Sci., January 1, 2007; 120(1): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chaput, C. Flament, S. Viaud, J. Taieb, S. Roux, A. Spatz, F. Andre, J.-B. LePecq, M. Boussac, J. Garin, et al. Dendritic cell derived-exosomes: biology and clinical implementations J. Leukoc. Biol., September 1, 2006; 80(3): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Del-Rey, J. Ruiz-Contreras, A. Bosque, S. Calleja, J. Gomez-Rial, E. Roldan, P. Morales, A. Serrano, A. Anel, E. Paz-Artal, et al. A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome Blood, August 15, 2006; 108(4): 1306 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Taylor, S. Akyol, and C. Gercel-Taylor Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling J. Immunol., February 1, 2006; 176(3): 1534 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Baum, V. Kirkin, S. B. M. Fernandez, R. Pick, M. Lettau, O. Janssen, and M. Zornig Binding of the Intracellular Fas Ligand (FasL) Domain to the Adaptor Protein PSTPIP Results in a Cytoplasmic Localization of FasL J. Biol. Chem., December 2, 2005; 280(48): 40012 - 40024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Straszewski-Chavez, V. M. Abrahams, and G. Mor The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy Endocr. Rev., December 1, 2005; 26(7): 877 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Alonso, M. C. Rodriguez, J. Pindado, E. Merino, I. Merida, and M. Izquierdo Diacylglycerol Kinase {alpha} Regulates the Secretion of Lethal Exosomes Bearing Fas Ligand during Activation-induced Cell Death of T Lymphocytes J. Biol. Chem., August 5, 2005; 280(31): 28439 - 28450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, E. R. Lechman, N. Bianco, R. Menon, A. Keravala, J. Nash, Z. Mi, S. C. Watkins, A. Gambotto, and P. D. Robbins Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis J. Immunol., May 15, 2005; 174(10): 6440 - 6448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Martin-Fernandez, J. A. Cabanillas, M. Rivero-Carmena, E. Lacasa, J. Pardo, A. Anel, P. R. Ramirez-Duque, F. Merino, C. Rodriguez-Gallego, and J. R. Regueiro Herpesvirus saimiri-transformed CD8+ T cells as a tool to study Chediak-Higashi syndrome cytolytic lymphocytes J. Leukoc. Biol., May 1, 2005; 77(5): 661 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bosque, J. Pardo, M{a} J. Martinez-Lorenzo, M. Iturralde, I. Marzo, A. Pineiro, M{a} A. Alava, J. Naval, and A. Anel Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression J. Leukoc. Biol., April 1, 2005; 77(4): 568 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Monari, E. Pericolini, G. Bistoni, A. Casadevall, T. R. Kozel, and A. Vecchiarelli Cryptococcus neoformans Capsular Glucuronoxylomannan Induces Expression of Fas Ligand in Macrophages J. Immunol., March 15, 2005; 174(6): 3461 - 3468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Askenasy, E. S. Yolcu, I. Yaniv, and H. Shirwan Induction of tolerance using Fas ligand: a double-edged immunomodulator Blood, February 15, 2005; 105(4): 1396 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Frangsmyr, V. Baranov, O. Nagaeva, U. Stendahl, L. Kjellberg, and L. Mincheva-Nilsson Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level Mol. Hum. Reprod., January 1, 2005; 11(1): 35 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Dainiak, S K Schreyer, and J Albanese The search for mRNA biomarkers: global quantification of transcriptional and translational responses to ionising radiation Br. J. Radiol., January 1, 2005; Supplement_27(1): 114 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Morelli, A. T. Larregina, W. J. Shufesky, M. L. G. Sullivan, D. B. Stolz, G. D. Papworth, A. F. Zahorchak, A. J. Logar, Z. Wang, S. C. Watkins, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells Blood, November 15, 2004; 104(10): 3257 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Xiao, U. S. Deshmukh, S. Jodo, T. Koike, R. Sharma, A. Furusaki, S.-s. J. Sung, and S.-T. Ju Novel Negative Regulator of Expression in Fas Ligand (CD178) Cytoplasmic Tail: Evidence for Translational Regulation and against Fas Ligand Retention in Secretory Lysosomes J. Immunol., October 15, 2004; 173(8): 5095 - 5102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Abrahams, S. L. Straszewski-Chavez, S. Guller, and G. Mor First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis Mol. Hum. Reprod., January 1, 2004; 10(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Abrahams, S. L. Straszewski, M. Kamsteeg, B. Hanczaruk, P. E. Schwartz, T. J. Rutherford, and G. Mor Epithelial Ovarian Cancer Cells Secrete Functional Fas Ligand Cancer Res., September 1, 2003; 63(17): 5573 - 5581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Greil, G. Anether, K. Johrer, and I. Tinhofer Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools J. Leukoc. Biol., September 1, 2003; 74(3): 311 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yang, I. Tikhonov, T. J. Ruckwardt, M. Djavani, J. C. Zapata, C. D. Pauza, and M. S. Salvato Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+ Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated Mechanism J. Virol., June 15, 2003; 77(12): 6700 - 6708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Renshaw, J. S. Parmar, V. Singleton, S. J. Rowe, D. H. Dockrell, S. K. Dower, C. D. Bingle, E. R. Chilvers, and M. K. B. Whyte Acceleration of Human Neutrophil Apoptosis by TRAIL J. Immunol., January 15, 2003; 170(2): 1027 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Andreola, L. Rivoltini, C. Castelli, V. Huber, P. Perego, P. Deho, P. Squarcina, P. Accornero, F. Lozupone, L. Lugini, et al. Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles J. Exp. Med., May 20, 2002; 195(10): 1303 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Blanchard, D. Lankar, F. Faure, A. Regnault, C. Dumont, G. Raposo, and C. Hivroz TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/{zeta} Complex J. Immunol., April 1, 2002; 168(7): 3235 - 3241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Monleon, M. J. Martinez-Lorenzo, L. Monteagudo, P. Lasierra, M. Taules, M. Iturralde, A. Pineiro, L. Larrad, M. A. Alava, J. Naval, et al. Differential Secretion of Fas Ligand- or APO2 Ligand/TNF-Related Apoptosis-Inducing Ligand-Carrying Microvesicles During Activation-Induced Death of Human T Cells J. Immunol., December 15, 2001; 167(12): 6736 - 6744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Siegmund, A. Hausser, N. Peters, P. Scheurich, and H. Wajant Tumor Necrosis Factor (TNF) and Phorbol Ester Induce TNF-related Apoptosis-inducing Ligand (TRAIL) under Critical Involvement of NF-kappa B Essential Modulator (NEMO)/IKKgamma J. Biol. Chem., November 16, 2001; 276(47): 43708 - 43712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jodo, S. Xiao, A. Hohlbaum, D. Strehlow, A. Marshak-Rothstein, and S.-T. Ju Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES J. Biol. Chem., October 19, 2001; 276(43): 39938 - 39944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Secchiero, P. Mirandola, D. Zella, C. Celeghini, A. Gonelli, M. Vitale, S. Capitani, and G. Zauli Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4+ T cells Blood, October 15, 2001; 98(8): 2474 - 2481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Baetu, H. Kwon, S. Sharma, N. Grandvaux, and J. Hiscott Disruption of NF-{kappa}B Signaling Reveals a Novel Role for NF-{kappa}B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression J. Immunol., September 15, 2001; 167(6): 3164 - 3173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Renz, W. E. Berdel, M. Kreuter, C. Belka, K. Schulze-Osthoff, and M. Los Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo Blood, September 1, 2001; 98(5): 1542 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Di Pietro, P. Secchiero, R. Rana, D. Gibellini, G. Visani, K. Bemis, L. Zamai, S. Miscia, and G. Zauli Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1 Blood, May 1, 2001; 97(9): 2596 - 2603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Miura, N. Misawa, N. Maeda, Y. Inagaki, Y. Tanaka, M. Ito, N. Kayagaki, N. Yamamoto, H. Yagita, H. Mizusawa, et al. Critical Contribution of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) to Apoptosis of Human Cd4+T Cells in HIV-1-Infected Hu-Pbl-Nod-Scid Mice J. Exp. Med., March 5, 2001; 193(5): 651 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D'Alessio, A. Riccioli, P. Lauretti, F. Padula, B. Muciaccia, P. De Cesaris, A. Filippini, S. Nagata, and E. Ziparo Testicular FasL is expressed by sperm cells PNAS, February 22, 2001; (2001) 51566098. [Abstract] [Full Text]
|
|
|
|
|
|
S. Jodo, A. M. Hohlbaum, S. Xiao, D. Chan, D. Strehlow, D. H. Sherr, A. Marshak-Rothstein, and S.-T. Ju CD95 (Fas) Ligand-Expressing Vesicles Display Antibody-Mediated, FcR-Dependent Enhancement of Cytotoxicity J. Immunol., November 15, 2000; 165(10): 5487 - 5494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Austin Taylor, M. Bennett, V. Kumar, and J. D. Schatzle Functional Defects of NK Cells Treated with Chloroquine Mimic the Lytic Defects Observed in Perforin-Deficient Mice J. Immunol., November 1, 2000; 165(9): 5048 - 5053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Traidl, S. Sebastiani, C. Albanesi, H. F. Merk, P. Puddu, G. Girolomoni, and A. Cavani Disparate Cytotoxic Activity of Nickel-Specific CD8+ and CD4+ T Cell Subsets Against Keratinocytes J. Immunol., September 15, 2000; 165(6): 3058 - 3064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zamai, P. Secchiero, S. Pierpaoli, A. Bassini, S. Papa, E. S. Alnemri, L. Guidotti, M. Vitale, and G. Zauli TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis Blood, June 15, 2000; 95(12): 3716 - 3724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jodo, D. Strehlow, and S.-T. Ju Bioactivities of Fas Ligand-Expressing Retroviral Particles J. Immunol., May 15, 2000; 164(10): 5062 - 5069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Bergmann-Leitner and S. I. Abrams Differential Role of Fas/Fas Ligand Interactions in Cytolysis of Primary and Metastatic Colon Carcinoma Cell Lines by Human Antigen-Specific CD8+ CTL J. Immunol., May 1, 2000; 164(9): 4941 - 4954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D'Alessio, A. Riccioli, P. Lauretti, F. Padula, B. Muciaccia, P. De Cesaris, A. Filippini, S. Nagata, and E. Ziparo Testicular FasL is expressed by sperm cells PNAS, March 13, 2001; 98(6): 3316 - 3321. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
