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*
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and
Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115
To study the lifespan of virgin T lymphocytes, we removed the
thymus from adult female mice and then, at various times afterward,
tested their ability to mount an immune response to a newly encountered
Ag, the male Ag H-Y. We found that unprimed thymectomized mice were
able to generate a primary response to H-Y for some time after
thymectomy but lost this ability at 
6 mo. In contrast, mice that
were primed to H-Y just after thymectomy continued to display
immunological memory to H-Y for >1 year. These experiments show that
primary immune responses disappear in the absence of a
thymus.
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