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CUTTING EDGE |
*
Department of Immunology, University of Washington, Seattle, WA 98195; and
Bristol-Myers Squibb, Princeton, NJ 06540
CD40 ligand (CD40L) plays a crucial role in T cell-dependent B
cell responses, but whether its abundance is a limiting factor in their
development is unclear. This question was addressed in transgenic mice
expressing the murine CD40L gene under the control of the IL-2-promoter
(CD40Ltg+). The fraction of activated T cells from the
CD40Ltg+ mice with detectable levels of surface CD40L was
modestly greater (1.1- to 2-fold) than littermate controls and
paralleled an 
1.8-fold increase in CD40L mRNA abundance. In response
to trinitrophenol (TNP)-keyhole limpet hemocyanin and
tetanus/diphtheria vaccine, CD40Ltg+ mice developed higher
titers of high-affinity IgG and IgG1 Ab than wild-type mice. In
contrast, the Ab response of CD40Ltg+ and control mice was
similar in response to the T-independent Ag TNP-Ficoll. These results
suggest that a modest increment in expression of CD40L accelerates the
development of T-dependent responses, and that CD40L plays a limiting
role in the induction of high-affinity Ab and Ab-class
switching.
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