HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huseby, E. S. Articles by Goverman, J. Search for Related Content PubMed PubMed Citation Articles by Huseby, E. S. Articles by Goverman, J.

Cutting Edge: Myelin Basic Protein-Specific Cytotoxic T Cell Tolerance Is Maintained In Vivo by a Single Dominant Epitope in H-2^k Mice¹

Eric S. Huseby^*, Claes Öhlén^* and Joan Goverman^2,*,

^* Departments of Immunology and Molecular Biotechnology, University of Washington, Seattle, WA 98195

Multiple sclerosis (MS) is believed to be an autoimmune disease mediated by T cells specific for CNS Ags. MS lesions contain both CD4⁺ and CD8⁺ T lymphocytes. The contribution of CD4⁺ T cells to CNS autoimmune disease has been extensively studied in an animal model of MS, experimental autoimmune encephalomyelitis. However, little is known about the role of autoreactive CD8⁺ cytotoxic T cells in MS or experimental autoimmune encephalomyelitis. We demonstrate here that myelin basic protein (MBP) is processed in vivo by the MHC class I pathway leading to a MBP_79–87/K^k complex. The recognition of this complex by MBP-specific cytotoxic T cells leads to a high degree of tolerance in vivo. This study is the first to show that the pool of self-reactive lymphocytes specific for MBP contain MHC class I-restricted T cells whose response is regulated in vivo by the induction of tolerance.

This article has been cited by other articles:

				Q. JI and J. GOVERMAN Experimental Autoimmune Encephalomyelitis Mediated by CD8+ T Cells Ann. N.Y. Acad. Sci., April 1, 2007; 1103(1): 157 - 166. [Abstract] [Full Text] [PDF]

				I. Tsunoda, L.-Q. Kuang, M. Kobayashi-Warren, and R. S. Fujinami Central Nervous System Pathology Caused by Autoreactive CD8+ T-Cell Clones following Virus Infection J. Virol., December 1, 2005; 79(23): 14640 - 14646. [Abstract] [Full Text] [PDF]

				M. A. Friese and L. Fugger Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? Brain, August 1, 2005; 128(8): 1747 - 1763. [Abstract] [Full Text] [PDF]

				E. S. Huseby, D. Liggitt, T. Brabb, B. Schnabel, C. Ohlen, and J. Goverman A Pathogenic Role for Myelin-specific CD8+ T Cells in a Model for Multiple Sclerosis J. Exp. Med., September 4, 2001; 194(5): 669 - 676. [Abstract] [Full Text] [PDF]

				E. S. Huseby and J. Goverman Tolerating the Nervous System: A Delicate Balance J. Exp. Med., February 28, 2000; 191(5): 757 - 760. [Full Text] [PDF]