The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mukhopadhyay, S.
Right arrow Articles by Ravindran, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mukhopadhyay, S.
Right arrow Articles by Ravindran, B.
The Journal of Immunology, 1999, 163: 875-883.
Copyright © 1999 by The American Association of Immunologists

Delayed Clearance of Filarial Infection and Enhanced Th1 Immunity Due to Modulation of Macrophage APC Functions in xid Mice1

Sangita Mukhopadhyay*,{dagger}, Prakash Kumar Sahoo{dagger}, Anna George*, Vineeta Bal*, Satyajit Rath2,* and Bala Ravindran2,{dagger}

* National Institute of Immunology, New Delhi, India; and {dagger} Regional Medical Research Centre, Bhubaneswar, India

Bruton’s tyrosine kinase (Btk) mutant CBA/N mice show delayed clearance of injected microfilaria (mf) compared with wild-type CBA/J mice. Anti-mf T cells from CBA/N mice make relatively more IFN-{gamma} than those from CBA/J mice. The anti-mf T cell proliferative responses are also greater in CBA/N mice. This CBA/N immune phenotype is not restricted to filarial Ags, because immunization with pure proteins also yields T cell responses of greater proliferative magnitude skewed away from Th2 cytokines in CBA/N compared with CBA/J mice. The increased magnitude of CBA/N T cell proliferative responses is reflected in increases in both precursor frequencies and clonal burst sizes of responding Ag-specific T cells, and is independent of the source of re-stimulating APCs. Transfer of CBA/J peritoneal resident cells (PRCs) into CBA/N mice before pure protein immunization leads to a wild-type immune phenotype in the recipient CBA/N mice, with a reduction in the proliferative response and a relative decrease in the IFN-{gamma} produced. When wild-type PRC subpopulations are similarly transferred, the wild-type immune phenotype is transferred by macrophages rather than by B cells. Transfer of wild-type PRCs into CBA/N mice before injection of mf also causes similar changes in the anti-mf T cell responses and enhances the clearance of mf. Thus, Btk is involved in critical macrophage APC functions regulating priming of T cells, and can modulate these responses in pathophysiologically relevant fashion in vivo.




This article has been cited by other articles:


Home page
 BloodHome page
N. Khan, S. S. Rahim, C. S. Boddupalli, S. Ghousunnissa, S. Padma, N. Pathak, D. Thiagarajan, S. E. Hasnain, and S. Mukhopadhyay
Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein
Blood, February 15, 2006; 107(4): 1513 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Mangla, A. Khare, V. Vineeth, N. N. Panday, A. Mukhopadhyay, B. Ravindran, V. Bal, A. George, and S. Rath
Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses
Blood, August 15, 2004; 104(4): 1191 - 1197.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. F. Tsuji, M. Szczepanik, I. Kawikova, V. Paliwal, R. A. Campos, A. Itakura, M. Akahira-Azuma, N. Baumgarth, L. A. Herzenberg, and P. W. Askenase
B Cell-dependent T Cell Responses: IgM Antibodies Are Required to Elicit Contact Sensitivity
J. Exp. Med., November 18, 2002; 196(10): 1277 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Mukhopadhyay, M. Mohanty, A. Mangla, A. George, V. Bal, S. Rath, and B. Ravindran
Macrophage Effector Functions Controlled by Bruton's Tyrosine Kinase Are More Crucial Than the Cytokine Balance of T Cell Responses for Microfilarial Clearance
J. Immunol., March 15, 2002; 168(6): 2914 - 2921.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Paroli, D. Accapezzato, V. Francavilla, A. Insalaco, A. Plebani, F. Balsano, and V. Barnaba
Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia
Blood, March 15, 2002; 99(6): 2131 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
D. Cox, B. M. Dale, M. Kashiwada, C. D. Helgason, and S. Greenberg
A Regulatory Role for Src Homology 2 Domain-Containing Inositol 5'-Phosphatase (Ship) in Phagocytosis Mediated by Fc{gamma} Receptors and Complement Receptor 3 ({alpha}M{beta}2; Cd11b/Cd18)
J. Exp. Med., January 1, 2001; 193(1): 61 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Mukhopadhyay, A. George, V. Bal, B. Ravindran, and S. Rath
Bruton's Tyrosine Kinase Deficiency in Macrophages Inhibits Nitric Oxide Generation Leading to Enhancement of IL-12 Induction
J. Immunol., August 15, 1999; 163(4): 1786 - 1792.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.