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,
*
Basel Institute for Immunology, Basel, Switzerland; and Departments of
Zoology,
Genetics, and Cell Biology, Washington State University, Pulman, WA
The architecture of the MHC in teleost fish, which display a lack
of linkage between class I and II genes, differs from all other
vertebrates. Because rainbow trout have been examined for a variety of
immunologically relevant genes, they present a good teleost model for
examining both the expression and organization of MHC-related genes.
Full-length cDNA and partial gDNA clones for proteasome 
, low
molecular mass polypeptide (LMP) 2, TAP1, TAP2A, TAP2B, class Ia, and
class IIB were isolated for this study. Aside from the expected
polymorphisms associated with class I genes, LMP2 and TAP2 are
polygenic. More specifically, we found a unique lineage of LMP2
(LMP2/) that shares identity to both LMP2 and but is expressed
like the standard LMP2. Additionally, two very different TAP2 loci were
found, one of which encodes polymorphic alleles. In general, the class
I pathway genes are expressed in most tissues, with highest levels in
lymphoid tissue. We then analyzed the basic genomic organization of the
trout MHC in an isogenic backcross. The main class Ia region does not
cosegregate with the class IIB locus, but LMP2, LMP2/, TAP1A, and
TAP2B are linked to the class Ia locus. Interestingly, TAP2A (second
TAP2 locus) is a unique lineage in sequence composition that appears
not to be linked to this cluster or to class IIB. These results support
and extend the recent findings of nonlinkage between class I and II in
a different teleost order (cyprinids), suggesting that this unique
arrangement is common to all teleosts.
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