| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Chain Gene
,
*
Bioscience Research and Development Laboratory, Asahi Breweries, Ibaraki, Japan; and
Department of Immunology and
Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
Key regulatory regions necessary for the expression of the gene
encoding Fc
RI 
-chain, a component of the high-affinity IgE
receptor primarily responsible for IgE-dependent allergic response,
were investigated. Two regions, -74/-69 and -55/-47, which
contained binding motifs for proteins belonging to the Ets family and
the GATA family, respectively, were shown to be necessary for the
activation of the -chain promoter. Both the regulatory elements
enhanced the promoter activity only in -chain-producing cells PT18
and RBL-2H3 (mast cell lines), indicating that the elements required
specific trans-acting proteins present in the
-chain-producing cells. EMSA using nuclear extracts and in
vitro-translated proteins revealed that Elf-1 and GATA-1 bound to the
enhancer elements. This is the first report describing the regulation
in the expression of the FcRI -chain.
This article has been cited by other articles:
|
|
 |
|
  S. Kanada, N. Nakano, D. P. Potaczek, K. Maeda, N. Shimokawa, Y. Niwa, T. Fukai, M. Sanak, A. Szczeklik, H. Yagita, et al. Two Different Transcription Factors Discriminate the -315C>T Polymorphism of the Fc{epsilon}RI{alpha} Gene: Binding of Sp1 to -315C and of a High Mobility Group-Related Molecule to -315T J. Immunol., June 15, 2008; 180(12): 8204 - 8210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Martelli, B. Ghinassi, R. Lorenzini, A. M. Vannucchi, R. A. Rana, M. Nishikawa, S. Partamian, G. Migliaccio, and A. R. Migliaccio Thrombopoietin Inhibits Murine Mast Cell Differentiation Stem Cells, April 1, 2008; 26(4): 912 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakano, C. Nishiyama, S. Kanada, Y. Niwa, N. Shimokawa, H. Ushio, M. Nishiyama, K. Okumura, and H. Ogawa Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections Blood, June 1, 2007; 109(11): 4846 - 4855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masuda, K. Hashimoto, T. Yokoi, T. Doi, T. Kodama, H. Kume, K. Ohno, and T. Matsuguchi Essential Role of GATA Transcriptional Factors in the Activation of Mast Cells J. Immunol., January 1, 2007; 178(1): 360 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Maeda, C. Nishiyama, T. Tokura, H. Nakano, S. Kanada, M. Nishiyama, K. Okumura, and H. Ogawa FOG-1 represses GATA-1-dependent Fc{epsilon}RI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice Blood, July 1, 2006; 108(1): 262 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nishiyama, T. Ito, M. Nishiyama, S. Masaki, K. Maeda, N. Nakano, W. Ng, K. Fukuyama, M. Yamamoto, K. Okumura, et al. GATA-1 is required for expression of Fc{varepsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow Int. Immunol., July 1, 2005; 17(7): 847 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nishiyama, Y. Akizawa, M. Nishiyama, T. Tokura, H. Kawada, K. Mitsuishi, M. Hasegawa, T. Ito, N. Nakano, A. Okamoto, et al. Polymorphisms in the Fc{epsilon}RI{beta} Promoter Region Affecting Transcription Activity: A Possible Promoter-Dependent Mechanism for Association between Fc{epsilon}RI{beta} and Atopy J. Immunol., November 15, 2004; 173(10): 6458 - 6464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masuda, Y. Yoshikai, H. Kume, and T. Matsuguchi The Interaction between GATA Proteins and Activator Protein-1 Promotes the Transcription of IL-13 in Mast Cells J. Immunol., November 1, 2004; 173(9): 5564 - 5573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, et al. A Novel -66T/C Polymorphism in Fc{epsilon}RI {alpha}-Chain Promoter Affecting the Transcription Activity: Possible Relationship to Allergic Diseases J. Immunol., August 15, 2003; 171(4): 1927 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Takahashi, T. Ito, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa Regulation of the Human Fc{epsilon}RI {alpha}-Chain Distal Promoter J. Immunol., April 1, 2003; 170(7): 3732 - 3738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Migliaccio, R. A. Rana, M. Sanchez, R. Lorenzini, L. Centurione, L. Bianchi, A. M. Vannucchi, G. Migliaccio, and S. H. Orkin GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant J. Exp. Med., February 3, 2003; 197(3): 281 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Maeda, C. Nishiyama, T. Tokura, Y. Akizawa, M. Nishiyama, H. Ogawa, K. Okumura, and C. Ra Regulation of Cell Type-Specific Mouse Fc{epsilon}RI {beta}-Chain Gene Expression by GATA-1 Via Four GATA Motifs in the Promoter J. Immunol., January 1, 2003; 170(1): 334 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nishiyama, M. Hasegawa, M. Nishiyama, K. Takahashi, Y. Akizawa, T. Yokota, K. Okumura, H. Ogawa, and C. Ra Regulation of Human Fc{epsilon}RI {alpha}-Chain Gene Expression by Multiple Transcription Factors J. Immunol., May 1, 2002; 168(9): 4546 - 4552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Suzuki-Ishigaki, K. Numayama-Tsuruta, A. Kuramasu, E. Sakurai, Y. Makabe, S. Shimura, K. Shirato, K. Igarashi, T. Watanabe, and H. Ohtsu The mouse L-histidine decarboxylase gene: structure and transcriptional regulation by CpG methylation in the promoter region Nucleic Acids Res., July 15, 2000; 28(14): 2627 - 2633. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
