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CUTTING EDGE |
and IFN-
Causes Redistribution of Junctional Adhesion Molecule in Human Endothelial Cells1
*
Department of Geriatric Medicine, Graduate School of Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan; and
Central Laboratories for Key Technology, Kirin Brewery, Yokohama, Japan
Proinflammatory cytokines such as TNF-
and IFN-
induce
cell adhesion molecules in endothelial cells and promote transmigration
of leukocytes across endothelial cells. However, when those two were
administered together, leukocyte transmigration paradoxically
decreased. We cloned a human and bovine homologue of the junctional
adhesion molecule (JAM), a novel molecule at the tight junction, and
examined the effects of proinflammatory cytokines on JAM in HUVECs. The
combined treatment of TNF- plus IFN- caused a disappearance of
JAM from intercellular junctions. However, flow cytometry, cell ELISA,
and subcellular fractionation analysis demonstrated that the amount of
JAM was not reduced. This suggested that JAM changed its distribution
in response to proinflammatory cytokines. This redistribution of JAM
might be involved in a decrease in transendothelial migration of
leukocytes at inflammatory sites.
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 S. K. Shaw, B. N. Perkins, Y.-C. Lim, Y. Liu, A. Nusrat, F. J. Schnell, C. A. Parkos, and F. W. Luscinskas Reduced Expression of Junctional Adhesion Molecule and Platelet/Endothelial Cell Adhesion Molecule-1 (CD31) at Human Vascular Endothelial Junctions by Cytokines Tumor Necrosis Factor-{alpha} Plus Interferon-{gamma} Does Not Reduce Leukocyte Transmigration Under Flow Am. J. Pathol., December 1, 2001; 159(6): 2281 - 2291. [Abstract] [Full Text] [PDF]
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M. P. Arrate, J. M. Rodriguez, T. M. Tran, T. A. Brock, and S. A. Cunningham Cloning of Human Junctional Adhesion Molecule 3 (JAM3) and Its Identification as the JAM2 Counter-receptor J. Biol. Chem., November 30, 2001; 276(49): 45826 - 45832. [Abstract] [Full Text] [PDF]
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A. Yoshioka, R. Shirakawa, H. Nishioka, A. Tabuchi, T. Higashi, H. Ozaki, A. Yamamoto, T. Kita, and H. Horiuchi Identification of Protein Kinase Calpha as an Essential, but Not Sufficient, Cytosolic Factor for Ca2+-induced alpha - and Dense-core Granule Secretion in Platelets J. Biol. Chem., October 12, 2001; 276(42): 39379 - 39385. [Abstract] [Full Text] [PDF]
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M. Itoh, H. Sasaki, M. Furuse, H. Ozaki, T. Kita, and S. Tsukita Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions J. Cell Biol., August 6, 2001; 154(3): 491 - 498. [Abstract] [Full Text] [PDF]
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U. Naik, M. Naik, K Eckfeld, P Martin-DeLeon, and J Spychala Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody J. Cell Sci., January 2, 2001; 114(3): 539 - 547. [Abstract] [PDF]
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 T. W. Liang, R. A. DeMarco, R. J. Mrsny, A. Gurney, A. Gray, J. Hooley, H. L. Aaron, A. Huang, T. Klassen, D. B. Tumas, et al. Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1733 - C1743. [Abstract] [Full Text] [PDF]
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 A. Nusrat, J. R. Turner, and J. L. Madara Molecular Physiology and Pathophysiology of Tight Junctions: IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells Am J Physiol Gastrointest Liver Physiol, November 1, 2000; 279(5): G851 - G857. [Abstract] [Full Text] [PDF]
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M. B. Sobocka, T. Sobocki, P. Banerjee, C. Weiss, J. I. Rushbrook, A. J. Norin, J. Hartwig, M. O. Salifu, M. S. Markell, A. Babinska, et al. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation Blood, April 15, 2000; 95(8): 2600 - 2609. [Abstract] [Full Text] [PDF]
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Y Liu, A Nusrat, F. Schnell, T. Reaves, S Walsh, M Pochet, and C. Parkos Human junction adhesion molecule regulates tight junction resealing in epithelia J. Cell Sci., January 7, 2000; 113(13): 2363 - 2374. [Abstract] [PDF]
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J Mankertz, S Tavalali, H Schmitz, A Mankertz, E. Riecken, M Fromm, and J. Schulzke Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma J. Cell Sci., January 6, 2000; 113(11): 2085 - 2090. [Abstract] [PDF]
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C Johnson-Leger, M Aurrand-Lions, and B. Imhof The parting of the endothelium: miracle, or simply a junctional affair? J. Cell Sci., January 3, 2000; 113(6): 921 - 933. [Abstract] [PDF]
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S. A. Cunningham, M. P. Arrate, J. M. Rodriguez, R. J. Bjercke, P. Vanderslice, A. P. Morris, and T. A. Brock A Novel Protein with Homology to the Junctional Adhesion Molecule. CHARACTERIZATION OF LEUKOCYTE INTERACTIONS J. Biol. Chem., October 27, 2000; 275(44): 34750 - 34756. [Abstract] [Full Text] [PDF]
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D. Palmeri, A. van Zante, C.-C. Huang, S. Hemmerich, and S. D. Rosen Vascular Endothelial Junction-associated Molecule, a Novel Member of the Immunoglobulin Superfamily, Is Localized to Intercellular Boundaries of Endothelial Cells J. Biol. Chem., June 16, 2000; 275(25): 19139 - 19145. [Abstract] [Full Text] [PDF]
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G. Bazzoni, O. M. Martinez-Estrada, F. Mueller, P. Nelboeck, G. Schmid, T. Bartfai, E. Dejana, and M. Brockhaus Homophilic Interaction of Junctional Adhesion Molecule J. Biol. Chem., September 29, 2000; 275(40): 30970 - 30976. [Abstract] [Full Text] [PDF]
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O. M. Martinez-Estrada, A. Villa, F. Breviario, F. Orsenigo, E. Dejana, and G. Bazzoni Association of Junctional Adhesion Molecule with Calcium/calmodulin-dependent Serine Protein Kinase (CASK/LIN-2) in Human Epithelial Caco-2 Cells J. Biol. Chem., March 16, 2001; 276(12): 9291 - 9296. [Abstract] [Full Text] [PDF]
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