| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany;
Amgen Research Institute, Ontario Cancer Institute, Department of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada
Efficient T cell activation requires both TCR signals and
costimulatory signals. CD28 is one of the molecules that provide
costimulatory signals for T cells. We used mice deficient in CD28
expression (CD28-/- mice) to analyze the role of CD28 in
the immune response against the intracellular bacterium
Salmonella typhimurium, the causative agent of murine
typhoid fever. CD28-/- mice were highly susceptible to
infection with wild-type S. typhimurium and even failed
to control infection with attenuated
aroA- S. typhimurium.
More detailed analysis revealed that CD28-/-
animals did not mount a T-dependent Ab response and were highly
impaired in the production of IFN-
. Thus, CD28 cosignaling is
crucial for immunity against S. typhimurium. To our
knowledge, this is the first report describing an essential role for
CD28 in protective immunity against an intracellular microbial
pathogen.
This article has been cited by other articles:
|
|
 |
|
  I. Torii, S. Oka, M. Hotomi, W. H. Benjamin Jr, T. Takai, J. F. Kearney, D. E. Briles, and H. Kubagawa PIR-B-Deficient Mice Are Susceptible to Salmonella Infection J. Immunol., September 15, 2008; 181(6): 4229 - 4239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dufner, G. S. Duncan, A. Wakeham, A. R. Elford, H. T. Hall, P. S. Ohashi, and T. W. Mak CARD6 Is Interferon Inducible but Not Involved in Nucleotide-Binding Oligomerization Domain Protein Signaling Leading to NF-{kappa}B Activation Mol. Cell. Biol., March 1, 2008; 28(5): 1541 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fuse, W. Zhang, and E. J. Usherwood Control of Memory CD8+ T Cell Differentiation by CD80/CD86-CD28 Costimulation and Restoration by IL-2 during the Recall Response J. Immunol., January 15, 2008; 180(2): 1148 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Marks, M. Verolin, A. Stensson, and N. Lycke Differential CD28 and Inducible Costimulatory Molecule Signaling Requirements for Protective CD4+ T-Cell-Mediated Immunity against Genital Tract Chlamydia trachomatis Infection Infect. Immun., September 1, 2007; 75(9): 4638 - 4647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Caron, L. Lariviere, M. Nacache, M. Tam, M. M. Stevenson, C. McKerly, P. Gros, and D. Malo Influence of Slc11a1 on the Outcome of Salmonella enterica Serovar Enteritidis Infection in Mice Is Associated with Th Polarization. Infect. Immun., May 1, 2006; 74(5): 2787 - 2802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Honstettre, S. Meghari, J. A. Nunes, H. Lepidi, D. Raoult, D. Olive, and J.-L. Mege Role for the CD28 Molecule in the Control of Coxiella burnetii Infection Infect. Immun., March 1, 2006; 74(3): 1800 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vidric, A. T. Bladt, U. Dianzani, and T. H. Watts Role for Inducible Costimulator in Control of Salmonella enterica Serovar Typhimurium Infection in Mice Infect. Immun., February 1, 2006; 74(2): 1050 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. al-Ramadi, M. J. Fernandez-Cabezudo, A. Ullah, H. El-Hasasna, and R. A. Flavell CD154 Is Essential for Protective Immunity in Experimental Salmonella Infection: Evidence for a Dual Role in Innate and Adaptive Immune Responses J. Immunol., January 1, 2006; 176(1): 496 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Fernandez-Cabezudo, A. Ullah, R. A. Flavell, and B. K. al-Ramadi Evidence for the requirement for CD40--CD154 interactions in resistance to infections with attenuated Salmonella Innate Immunity, December 1, 2005; 11(6): 395 - 399. [Abstract] [PDF]
|
|
|
|
|
|
T. Rummel, J. Batchelder, P. Flaherty, G. LaFleur, P. Nanavati, J. M. Burns, and W. P. Weidanz CD28 Costimulation Is Required for the Expression of T-Cell-Dependent Cell-Mediated Immunity against Blood-Stage Plasmodium chabaudi Malaria Parasites Infect. Immun., October 1, 2004; 72(10): 5768 - 5774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Garcia, M. Martin, and S. M. Michalek Role of B7 Costimulatory Molecules in Mediating Systemic and Mucosal Antibody Responses to Attenuated Salmonella enterica Serovar Typhimurium and Its Cloned Antigen Infect. Immun., October 1, 2004; 72(10): 5824 - 5831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-R. T. Motameni, I. J. Juncadella, S. K. Ananthanarayanan, M. N. Hedrick, Y. Huet-Hudson, and J. Anguita Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants Infect. Immun., June 1, 2004; 72(6): 3638 - 3642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Monack, D. M. Bouley, and S. Falkow Salmonella typhimurium Persists within Macrophages in the Mesenteric Lymph Nodes of Chronically Infected Nramp1+/+ Mice and Can Be Reactivated by IFN{gamma} Neutralization J. Exp. Med., January 20, 2004; 199(2): 231 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen and D. M. Schifferli Construction, Characterization, and Immunogenicity of an Attenuated Salmonella enterica Serovar Typhimurium pgtE Vaccine Expressing Fimbriae with Integrated Viral Epitopes from the spiC Promoter Infect. Immun., August 1, 2003; 71(8): 4664 - 4673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Miyahira, M. Katae, S. Kobayashi, T. Takeuchi, Y. Fukuchi, R. Abe, K. Okumura, H. Yagita, and T. Aoki Critical Contribution of CD28-CD80/CD86 Costimulatory Pathway to Protection from Trypanosoma cruzi Infection Infect. Immun., June 1, 2003; 71(6): 3131 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mastroeni, and N. Menager Development of acquired immunity to Salmonella J. Med. Microbiol., June 1, 2003; 52(6): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Montagnoli, A. Bacci, S. Bozza, R. Gaziano, P. Mosci, A. H. Sharpe, and L. Romani B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans J. Immunol., December 1, 2002; 169(11): 6298 - 6308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Koebernick, L. Grode, J. R. David, W. Rohde, M. S. Rolph, H.-W. Mittrucker, and S. H. E. Kaufmann Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium PNAS, October 15, 2002; 99(21): 13681 - 13686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Rajagopalan, M. K. Smart, E. V. Marietta, and C. S. David Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28-deficient HLA-DQ8 transgenic mice Int. Immunol., July 1, 2002; 14(7): 801 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Compton and J. P. Farrell CD28 Costimulation and Parasite Dose Combine to Influence the Susceptibility of BALB/c Mice to Infection with Leishmania major J. Immunol., February 1, 2002; 168(3): 1302 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-W. Mittrucker, M. Kursar, A. Kohler, R. Hurwitz, and S. H. E. Kaufmann Role of CD28 for the Generation and Expansion of Antigen-Specific CD8+ T Lymphocytes During Infection with Listeria monocytogenes J. Immunol., November 15, 2001; 167(10): 5620 - 5627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen and D. M. Schifferli Mucosal and Systemic Immune Responses to Chimeric Fimbriae Expressed by Salmonella enterica Serovar Typhimurium Vaccine Strains Infect. Immun., June 1, 2000; 68(6): 3129 - 3139. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
