| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B-Mediated Transcription of CD86 Gene in APC1
Departments of
*
Pathology and
Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032; and
Department of Surgery, Universita Degli Studi di Roma "La Sapienza," Instituto di II Clinica Chirurgica Servizio Trapianti d’Organo, Rome, Italy
CD8+CD28- human T suppressor cells (Ts)
act on APC, inhibiting their ability to elicit Th activation and
proliferation. This effect is due to inhibition of the CD40 pathway
which normally leads to CD80 and CD86 up-regulation. To determine
whether Ts inhibit expression of B7 molecules by blocking
transcription, we cloned and characterized the CD86 promoter.
Mutational analysis revealed that Ts inhibit transcription driven by
the CD86 promoter. The NF-
B binding site, at -612 of the CD86
promoter, is essential for Th-induced transcription. In cultures
containing Th and Ts, Ts inhibit Th-induced NF-B activation in APC.
Together, these findings indicate that Ts inhibition of NF-B
activation in APC is a means by which they regulate the activation and
proliferation of Th.
This article has been cited by other articles:
|
|
 |
|
  G. Vlad, V. D. D'Agati, Q.-Y. Zhang, Z. Liu, E. K. Ho, T. Mohanakumar, M. A. Hardy, R. Cortesini, and N. Suciu-Foca Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice Diabetes, July 1, 2008; 57(7): 1878 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ben-David, A. Sharabi, M. Dayan, M. Sela, and E. Mozes The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand PNAS, October 30, 2007; 104(44): 17459 - 17464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Penna, S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini 1,25-Dihydroxyvitamin D3 Selectively Modulates Tolerogenic Properties in Myeloid but Not Plasmacytoid Dendritic Cells J. Immunol., January 1, 2007; 178(1): 145 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pellegatta, P. L. Poliani, D. Corno, F. Menghi, F. Ghielmetti, B. Suarez-Merino, V. Caldera, S. Nava, M. Ravanini, F. Facchetti, et al. Neurospheres Enriched in Cancer Stem-Like Cells Are Highly Effective in Eliciting a Dendritic Cell-Mediated Immune Response against Malignant Gliomas Cancer Res., November 1, 2006; 66(21): 10247 - 10252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Andreakos, R. O. Williams, J. Wales, B. M. Foxwell, and M. Feldmann Activation of NF-{kappa}B by the intracellular expression of NF-{kappa}B-inducing kinase acts as a powerful vaccine adjuvant PNAS, September 26, 2006; 103(39): 14459 - 14464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lietz, R. John, E. Burke, M. Schuster, T. B. Rogers, N. Suciu-Foca, D. Mancini, and S. Itescu Immunoglobulin M-to-Immunoglobulin G Anti-Human Leukocyte Antigen Class II Antibody Switching in Cardiac Transplant Recipients Is Associated With an Increased Risk of Cellular Rejection and Coronary Artery Disease Circulation, October 18, 2005; 112(16): 2468 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-L. Lin, Y.-C. Liang, S.-S. Lee, and B.-L. Chiang Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-{kappa}B and p38 mitogen-activated protein kinase pathways J. Leukoc. Biol., August 1, 2005; 78(2): 533 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Davila, Y. M. Kang, Y. W. Park, H. Sawai, X. He, S. Pryshchep, J. J. Goronzy, and C. M. Weyand Cell-Based Immunotherapy with Suppressor CD8+ T Cells in Rheumatoid Arthritis J. Immunol., June 1, 2005; 174(11): 7292 - 7301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vlad, R. Cortesini, and N. Suciu-Foca License to Heal: Bidirectional Interaction of Antigen-Specific Regulatory T Cells and Tolerogenic APC J. Immunol., May 15, 2005; 174(10): 5907 - 5914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohnuma, T. Yamochi, M. Uchiyama, K. Nishibashi, N. Yoshikawa, N. Shimizu, S. Iwata, H. Tanaka, N. H. Dang, and C. Morimoto CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1 PNAS, September 28, 2004; 101(39): 14186 - 14191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Manavalan, S. Kim-Schulze, L. Scotto, A. J. Naiyer, G. Vlad, P. C. Colombo, C. Marboe, D. Mancini, R. Cortesini, and N. Suciu-Foca Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity Int. Immunol., August 1, 2004; 16(8): 1055 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mocellin, E. Wang, M. Panelli, P. Pilati, and F. M. Marincola DNA Array-Based Gene Profiling in Tumor Immunology Clin. Cancer Res., July 15, 2004; 10(14): 4597 - 4606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Sieling, W. Chung, B. T. Duong, P. J. Godowski, and R. L. Modlin Toll-Like Receptor 2 Ligands as Adjuvants for Human Th1 Responses J. Immunol., January 1, 2003; 170(1): 194 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Kohm, A. Mozaffarian, and V. M. Sanders B Cell Receptor- and {beta}2-Adrenergic Receptor-Induced Regulation of B7-2 (CD86) Expression in B Cells J. Immunol., June 15, 2002; 168(12): 6314 - 6322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Steptoe, J. M. Ritchie, and L. C. Harrison Increased Generation of Dendritic Cells from Myeloid Progenitors in Autoimmune-Prone Nonobese Diabetic Mice J. Immunol., May 15, 2002; 168(10): 5032 - 5041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Steinbrink, E. Graulich, S. Kubsch, J. Knop, and A. H. Enk CD4+ and CD8+ anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity Blood, April 1, 2002; 99(7): 2468 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Lim, W. Ma, K. Gee, S. Aucoin, D. Nandan, F. Diaz-Mitoma, M. Kozlowski, and A. Kumar Distinct Role of p38 and c-Jun N-Terminal Kinases in IL-10-Dependent and IL-10-Independent Regulation of the Costimulatory Molecule B7.2 in Lipopolysaccharide-Stimulated Human Monocytic Cells J. Immunol., February 15, 2002; 168(4): 1759 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hinz, P. Loser, S. Mathas, D. Krappmann, B. Dorken, and C. Scheidereit Constitutive NF-{kappa}B maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells Blood, May 1, 2001; 97(9): 2798 - 2807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Arrighi, M. Rebsamen, F. Rousset, V. Kindler, and C. Hauser A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-{{alpha}}, and Contact Sensitizers J. Immunol., March 15, 2001; 166(6): 3837 - 3845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-G. Roncarolo, M. K. Levings, and C. Traversari Differentiation of T Regulatory Cells by Immature Dendritic Cells J. Exp. Med., January 16, 2001; 193(2): F5 - F10. [Full Text] [PDF]
|
|
|
|
|
|
T. Maeda, M. Towatari, H. Kosugi, and H. Saito Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells Blood, December 1, 2000; 96(12): 3847 - 3856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lanzavecchia and F. Sallusto Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells Science, October 6, 2000; 290(5489): 92 - 97. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Lyakh, G. K. Koski, W. Telford, R. E. Gress, P. A. Cohen, and N. R. Rice Bacterial Lipopolysaccharide, TNF-{alpha}, and Calcium Ionophore Under Serum-Free Conditions Promote Rapid Dendritic Cell-Like Differentiation in CD14+ Monocytes Through Distinct Pathways That Activate NF-{kappa}B J. Immunol., October 1, 2000; 165(7): 3647 - 3655. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
