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B by EBV BZLF-1-Encoded ZEBRA Protein in Human T Cells1
Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206
We have previously shown that the EBV ZEBRA protein (also denoted
EB1, Z, or Zta) encoded by the BZLF open reading frame is expressed in
primary human thymocytes and in human T lymphoblastoid cell lines
infected by EBV. Expression of EBV-encoded gene products in T
lymphocytes could contribute to viral pathogenesis during acute EBV
infection as well as in individuals coinfected with EBV and HIV.
HPB-ALL and Jurkat T lymphoblastoid cell lines transiently and stably
expressing ZEBRA were characterized in this work. Expression of ZEBRA
protein in human T lymphoblastoid cells was associated with decreased
expression of an NF-
B reporter gene, altered expression of the
NF-B p50 protein subunit, and decreased DNA binding by components of
NF-B. These observations suggest that inactivation of NF-B
transcription by ZEBRA in EBV-infected T cells may be a novel mechanism
of viral pathogenesis analogous in part to over-expression of the
endogenous cytoplasmic inhibitor of NF-B,
IB
.
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