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*
Liver Research Laboratories and
Department of Rheumatology, Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom; and
LeukoSite, Cambridge, MA 02142
The role played by chemokines in regulating the selective
recruitment of lymphocytes to different tissue compartments in disease
is poorly characterized. In hepatitis C infection, inflammation
confined to portal areas is associated with a less aggressive course,
whereas T cell infiltration of the liver parenchyma is associated with
progressive liver injury and cirrhosis. We propose a mechanism to
explain how lymphocytes are recruited to hepatic lobules during bursts
of necroinflammatory activity in chronic hepatitis C infection. We
report here that lymphocytes infiltrating hepatitis C-infected liver
express high levels of the chemokine receptors CCR5 and CXCR3. However,
whereas the CCR5 ligands macrophage inflammatory protein-1
and -1ß
were largely confined to vessels within portal tracts, the CXCR3
ligands IFN-inducible protein-10 and monokine-induced by IFN-
were
selectively up-regulated on sinusoidal endothelium. In vitro, human
hepatic sinusoidal endothelial cells secreted IFN-inducible protein-10
and monokine-induced by IFN- in response to stimulation with IFN-
in combination with either IL-1 or TNF-. This suggests that
intrahepatic Th1 cytokines drive the increased expression of
IFN-inducible protein-10 and monokine-induced by IFN- and thereby
promote the continuing recruitment of CXCR3-expressing T cells into the
hepatic lobule in chronic hepatitis C infection.
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M. J. Smit, P. Verdijk, E. M. H. van der Raaij-Helmer, M. Navis, P. J. Hensbergen, R. Leurs, and C. P. Tensen CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase Blood, September 15, 2003; 102(6): 1959 - 1965. [Abstract] [Full Text] [PDF]
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K N Lowes, E J Croager, L J Abraham, J K Olynyk, and G C T Yeoh Upregulation of lymphotoxin {beta} expression in liver progenitor (oval) cells in chronic hepatitis C Gut, September 1, 2003; 52(9): 1327 - 1332. [Abstract] [Full Text]
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C. E. Harvey, J. J. Post, P. Palladinetti, A. J. Freeman, R. A. Ffrench, R. K. Kumar, G. Marinos, and A. R. Lloyd Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation J. Leukoc. Biol., September 1, 2003; 74(3): 360 - 369. [Abstract] [Full Text] [PDF]
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E. Belnoue, M. Kayibanda, J.-C. Deschemin, M. Viguier, M. Mack, W. A. Kuziel, and L. Renia CCR5 deficiency decreases susceptibility to experimental cerebral malaria Blood, June 1, 2003; 101(11): 4253 - 4259. [Abstract] [Full Text] [PDF]
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M. N. Ajuebor, C. M. Hogaboam, T. Le, and M. G. Swain C-C Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Directly Inhibits NKT Cell IL-4 Production and Is Hepatoprotective in T Cell-Mediated Hepatitis in the Mouse J. Immunol., May 15, 2003; 170(10): 5252 - 5259. [Abstract] [Full Text] [PDF]
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A H Lau and A W Thomson Dendritic cells and immune regulation in the liver Gut, February 1, 2003; 52(2): 307 - 314. [Abstract] [Full Text] [PDF]
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 S. Krauss-Etschmann, E. Sammler, S. Koletzko, N. Konstantopoulos, D. Aust, B. Gebert, B. Luckow, D. Reinhardt, and D. J. Schendel Chemokine Receptor 5 Expression in Gastric Mucosa of Helicobacter pylori-Infected and Noninfected Children Clin. Vaccine Immunol., January 1, 2003; 10(1): 22 - 29. [Abstract] [Full Text] [PDF]
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J. J. Yun, M. P. Fischbein, D. Whiting, Y. Irie, M. C. Fishbein, M. D. Burdick, J. Belperio, R. M. Strieter, H. Laks, J. A. Berliner, et al. The Role of MIG/CXCL9 in Cardiac Allograft Vasculopathy Am. J. Pathol., October 1, 2002; 161(4): 1307 - 1313. [Abstract] [Full Text] [PDF]
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P. F. Lalor, S. Edwards, G. McNab, M. Salmi, S. Jalkanen, and D. H. Adams Vascular Adhesion Protein-1 Mediates Adhesion and Transmigration of Lymphocytes on Human Hepatic Endothelial Cells J. Immunol., July 15, 2002; 169(2): 983 - 992. [Abstract] [Full Text] [PDF]
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K. Mohan, Z. Ding, J. Hanly, and T. B. Issekutz IFN-{gamma}-Inducible T Cell {alpha} Chemoattractant Is a Potent Stimulator of Normal Human Blood T Lymphocyte Transendothelial Migration: Differential Regulation by IFN-{gamma} and TNF-{alpha} J. Immunol., June 15, 2002; 168(12): 6420 - 6428. [Abstract] [Full Text] [PDF]
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E. Padovan, G. C. Spagnoli, M. Ferrantini, and M. Heberer IFN-{alpha}2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells J. Leukoc. Biol., April 1, 2002; 71(4): 669 - 676. [Abstract] [Full Text] [PDF]
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 H. Huang, F. Li, J. R. Gordon, and J. Xiang Synergistic Enhancement of Antitumor Immunity with Adoptively Transferred Tumor-specific CD4+ and CD8+ T Cells and Intratumoral Lymphotactin Transgene Expression Cancer Res., April 1, 2002; 62(7): 2043 - 2051. [Abstract] [Full Text] [PDF]
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A. J. Grant, S. Goddard, J. Ahmed-Choudhury, G. Reynolds, D. G. Jackson, M. Briskin, L. Wu, S. G. Hubscher, and D. H. Adams Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease Am. J. Pathol., April 1, 2002; 160(4): 1445 - 1455. [Abstract] [Full Text] [PDF]
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 K. Kai, K. Nasu, S. Nakamura, J. Fukuda, M. Nishida, and I. Miyakawa Expression of interferon-{gamma}-inducible protein-10 in human endometrial stromal cells Mol. Hum. Reprod., February 1, 2002; 8(2): 176 - 180. [Abstract] [Full Text] [PDF]
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M Heydtmann and D H Adams Understanding selective trafficking of lymphocyte subsets Gut, February 1, 2002; 50(2): 150 - 152. [Full Text] [PDF]
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N. A. Shackel, P. H. McGuinness, C. A. Abbott, M. D. Gorrell, and G. W. McCaughan Insights into the Pathobiology of Hepatitis C Virus-Associated Cirrhosis : Analysis of Intrahepatic Differential Gene Expression Am. J. Pathol., February 1, 2002; 160(2): 641 - 654. [Abstract] [Full Text] [PDF]
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K. Kakimi, T. E. Lane, S. Wieland, V. C. Asensio, I. L. Campbell, F. V. Chisari, and L. G. Guidotti Blocking Chemokine Responsive to {gamma}-2/Interferon (IFN)-{gamma} Inducible Protein and Monokine Induced by IFN-{gamma} Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus-specific Cytotoxic T Lymphocytes J. Exp. Med., December 17, 2001; 194(12): 1755 - 1766. [Abstract] [Full Text] [PDF]
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N A Shackel, P H McGuinness, C A Abbott, M D Gorrell, and G W McCaughan Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression Gut, October 1, 2001; 49(4): 565 - 576. [Abstract] [Full Text] [PDF]
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 M. A. GarcIa-Lopez, D. Sancho, F. Sanchez-Madrid, and M. Marazuela Thyrocytes from Autoimmune Thyroid Disorders Produce the Chemokines IP-10 And Mig and Attract CXCR3+ Lymphocytes J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5008 - 5016. [Abstract] [Full Text] [PDF]
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J. M. Faint, N. E. Annels, S. J. Curnow, P. Shields, D. Pilling, A. D. Hislop, L. Wu, A. N. Akbar, C. D. Buckley, P. A. H. Moss, et al. Memory T Cells Constitute a Subset of the Human CD8+CD45RA+ Pool with Distinct Phenotypic and Migratory Characteristics J. Immunol., July 1, 2001; 167(1): 212 - 220. [Abstract] [Full Text] [PDF]
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J.-W. Park, M. E. Gruys, K. McCormick, J.-K. Lee, J. Subleski, J. M. Wigginton, R. G. Fenton, J.-M. Wang, and R. H. Wiltrout Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN-{{gamma}} (Mig) and Chemokine Responsive to {{gamma}}-2 (Crg-2) J. Immunol., March 15, 2001; 166(6): 3763 - 3770. [Abstract] [Full Text] [PDF]
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R. Patzwahl, V. Meier, G. Ramadori, and S. Mihm Enhanced Expression of Interferon-Regulated Genes in the Liver of Patients with Chronic Hepatitis C Virus Infection: Detection by Suppression-Subtractive Hybridization J. Virol., February 1, 2001; 75(3): 1332 - 1338. [Abstract] [Full Text]
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M. T. Liu, D. Armstrong, T. A. Hamilton, and T. E. Lane Expression of Mig (Monokine Induced by Interferon-{{gamma}}) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System J. Immunol., February 1, 2001; 166(3): 1790 - 1795. [Abstract] [Full Text] [PDF]
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M. T. Liu, B. P. Chen, P. Oertel, M. J. Buchmeier, D. Armstrong, T. A. Hamilton, and T. E. Lane Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease J. Immunol., September 1, 2000; 165(5): 2327 - 2330. [Abstract] [Full Text] [PDF]
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 A. Bonacchi, P. Romagnani, R. G. Romanelli, E. Efsen, F. Annunziato, L. Lasagni, M. Francalanci, M. Serio, G. Laffi, M. Pinzani, et al. Signal Transduction by the Chemokine Receptor CXCR3. ACTIVATION OF Ras/ERK, Src, AND PHOSPHATIDYLINOSITOL 3-KINASE/Akt CONTROLS CELL MIGRATION AND PROLIFERATION IN HUMAN VASCULAR PERICYTES J. Biol. Chem., March 23, 2001; 276(13): 9945 - 9954. [Abstract] [Full Text] [PDF]
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