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*
Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304; and
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115
Optimal T cell activation and expansion require engagement of the
TCR plus costimulatory signals delivered through accessory molecules.
SLAM (signaling lymphocytic activation molecule), a 70-kDa
costimulatory molecule belonging to the Ig superfamily, was defined as
a human cell surface molecule that mediated CD28-independent
proliferation of human T cells and IFN-
production by human Th1 and
Th2 clones. In this study, we describe the cloning of mouse SLAM and
the production of mAb against it which reveal its expression on primary
mouse T and B cells. Mouse SLAM is expressed on highly polarized Th1
and Th2 populations, and is maintained on Th1, but not on Th2 clones.
Anti-mouse SLAM mAb augmented IFN- production by Th1 cells and Th1
clones stimulated through the TCR, but did not induce IFN-
production by Th2 cells, nor their production of IL-4 or their
proliferation. Mouse SLAM is a 75-kDa glycoprotein that upon tyrosine
phosphorylation associates with the src homology
2-domain-containing protein tyrosine phosphatase SHP-2, but not SHP-1.
Mouse SLAM also associates with the recently described human
SLAM-associated protein. These studies may provide new insights into
the regulation of Th1 responses.
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M. Martin, X. Romero, M. A. de la Fuente, V. Tovar, N. Zapater, E. Esplugues, P. Pizcueta, J. Bosch, and P. Engel CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-{gamma} Secretion: Adhesion Is Mediated by Ig-Like Domain 1 J. Immunol., October 1, 2001; 167(7): 3668 - 3676. [Abstract] [Full Text] [PDF]
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A. E. Morelli, A. F. Zahorchak, A. T. Larregina, B. L. Colvin, A. J. Logar, T. Takayama, L. D. Falo, and A. W. Thomson Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation Blood, September 1, 2001; 98(5): 1512 - 1523. [Abstract] [Full Text] [PDF]
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M. Kruse, E. Meinl, G. Henning, C. Kuhnt, S. Berchtold, T. Berger, G. Schuler, and A. Steinkasserer Signaling Lymphocytic Activation Molecule Is Expressed on Mature CD83+ Dendritic Cells and Is Up-Regulated by IL-1{beta} J. Immunol., August 15, 2001; 167(4): 1989 - 1995. [Abstract] [Full Text] [PDF]
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H. Tatsuo, N. Ono, and Y. Yanagi Morbilliviruses Use Signaling Lymphocyte Activation Molecules (CD150) as Cellular Receptors J. Virol., July 1, 2001; 75(13): 5842 - 5850. [Abstract] [Full Text] [PDF]
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 M. J. Czar, E. N. Kersh, L. A. Mijares, G. Lanier, J. Lewis, G. Yap, A. Chen, A. Sher, C. S. Duckett, R. Ahmed, et al. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP PNAS, June 7, 2001; (2001) 131193098. [Abstract] [Full Text] [PDF]
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L. M. Shlapatska, S. V. Mikhalap, A. G. Berdova, O. M. Zelensky, T. J. Yun, K. E. Nichols, E. A. Clark, and S. P. Sidorenko CD150 Association with Either the SH2-Containing Inositol Phosphatase or the SH2-Containing Protein Tyrosine Phosphatase Is Regulated by the Adaptor Protein SH2D1A J. Immunol., May 1, 2001; 166(9): 5480 - 5487. [Abstract] [Full Text] [PDF]
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N. Ono, H. Tatsuo, K. Tanaka, H. Minagawa, and Y. Yanagi V Domain of Human SLAM (CDw150) Is Essential for Its Function as a Measles Virus Receptor J. Virol., February 15, 2001; 75(4): 1594 - 1600. [Abstract] [Full Text]
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A. J. McAdam, T. T. Chang, A. E. Lumelsky, E. A. Greenfield, V. A. Boussiotis, J. S. Duke-Cohan, T. Chernova, N. Malenkovich, C. Jabs, V. K. Kuchroo, et al. Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells J. Immunol., November 1, 2000; 165(9): 5035 - 5040. [Abstract] [Full Text] [PDF]
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S. G. Tangye, J. H. Phillips, L. L. Lanier, and K. E. Nichols Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome J. Immunol., September 15, 2000; 165(6): 2932 - 2936. [Abstract] [Full Text] [PDF]
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N. Fournier, L. Chalus, I. Durand, E. Garcia, J.-J. Pin, T. Churakova, S. Patel, C. Zlot, D. Gorman, S. Zurawski, et al. FDF03, a Novel Inhibitory Receptor of the Immunoglobulin Superfamily, Is Expressed by Human Dendritic and Myeloid Cells J. Immunol., August 1, 2000; 165(3): 1197 - 1209. [Abstract] [Full Text] [PDF]
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C. Munz, K. L. Bickham, M. Subklewe, M. L. Tsang, A. Chahroudi, M. G. Kurilla, D. Zhang, M. O'Donnell, and R. M. Steinman Human CD4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen EBNA1 J. Exp. Med., May 8, 2000; 191(10): 1649 - 1660. [Abstract] [Full Text] [PDF]
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N. Mavaddat, D. W. Mason, P. D. Atkinson, E. J. Evans, R. J. C. Gilbert, D. I. Stuart, J. A. Fennelly, A. N. Barclay, S. J. Davis, and M. H. Brown Signaling Lymphocytic Activation Molecule (CDw150) Is Homophilic but Self-associates with Very Low Affinity J. Biol. Chem., September 1, 2000; 275(36): 28100 - 28109. [Abstract] [Full Text] [PDF]
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M. Morra, M. Simarro-Grande, M. Martin, A. S.-I. Chen, A. Lanyi, O. Silander, S. Calpe, J. Davis, T. Pawson, M. J. Eck, et al. Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients J. Biol. Chem., September 21, 2001; 276(39): 36809 - 36816. [Abstract] [Full Text] [PDF]
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M. J. Czar, E. N. Kersh, L. A. Mijares, G. Lanier, J. Lewis, G. Yap, A. Chen, A. Sher, C. S. Duckett, R. Ahmed, et al. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP PNAS, June 19, 2001; 98(13): 7449 - 7454. [Abstract] [Full Text] [PDF]
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