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Immunology Division and
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
The use of 129 strain-derived embryonic stem cell lines for
targeted gene mutation in mice has led directly to an expanded use of
this inbred strain worldwide. It has been noted, however, that the 129
genetic background can make a significant contribution to the severity
of a mutant phenotype. In this study, we reveal a specific defect in
the IL-5 and Rp105 responses of B lymphocytes from two widely used 129
mouse substrains. The response to stimulation through surface IgM is
also diminished, although to a lesser degree, in these mice. The lesion
appears to reduce significantly the expression of the 
-chain of the
IL-5R, but may also influence events downstream of the IL-5R. This
phenotype displays a codominant inheritance pattern, and is accompanied
by a variable but significant depression of peritoneal B-1 cell numbers
in 50% of the mice.
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