| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death1
Divisions of
*
Cell Biology and
Cellular Immunolgy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121
Activation-induced cell death is mediated by the TCR-induced
expression of the Fas ligand (FasL) on the surface of T cells, followed
by binding to its receptor Fas. FasL expression is induced by
stimulating T cells with a combination of phorbol ester and
Ca2+ ionophore, implicating a role for protein kinase C
(PKC) in this process. However, the precise mechanisms that regulate
FasL expression, including the contribution of distinct T
cell-expressed PKC isoforms, are poorly understood. Herein, we report
that PKC
, a Ca2+-independent PKC isoform that we have
previously isolated as a PKC enzyme selectively expressed in T cells,
plays an important role in these processes. A constitutively active
PKC mutant preferentially induced FasL expression and activated the
corresponding gene promoter; conversely, a dominant-negative PKC
mutant blocked FasL expression induced by anti-CD3 or PMA plus
ionomycin stimulation. Furthermore, PKC synergized with calcineurin
to provide a potent stimulus for FasL promoter activation. Full
activation of the promoter required its binding sites for the
transcription factors NF-AT, AP-1, and NF-
B. The biological
significance of these findings is implicated by the finding that
rottlerin, a selective PKC inhibitor, blocked FasL induction by
anti-CD3 or PMA plus ionomycin stimulation and, consequently,
protected human Jurkat T cells and the mouse T cell hybridoma A1.1 from
activation-induced cell death.
This article has been cited by other articles:
|
|
 |
|
  A. G. Granja, E. G. Sanchez, P. Sabina, M. Fresno, and Y. Revilla African Swine Fever Virus Blocks the Host Cell Antiviral Inflammatory Response through a Direct Inhibition of PKC-{theta}-Mediated p300 Transactivation J. Virol., January 15, 2009; 83(2): 969 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kao, J. Lin, D. R. Littman, A. S. Shaw, and P. M. Allen Regulated Movement of CD4 In and Out of the Immunological Synapse J. Immunol., December 15, 2008; 181(12): 8248 - 8257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Garaude, R. Farras, G. Bossis, S. Charni, M. Piechaczyk, R. A. Hipskind, and M. Villalba SUMOylation Regulates the Transcriptional Activity of JunB in T Lymphocytes J. Immunol., May 1, 2008; 180(9): 5983 - 5990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Shahabi, K. McAllen, and B. M. Sharp Stromal cell-derived factor 1-{alpha} (SDF)-induced human T cell chemotaxis becomes phosphoinositide 3-kinase (PI3K)-independent: role of PKC-{theta} J. Leukoc. Biol., March 1, 2008; 83(3): 663 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Granja, N. D. Perkins, and Y. Revilla A238L Inhibits NF-ATc2, NF-{kappa}B, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-{theta}-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300 J. Immunol., February 15, 2008; 180(4): 2429 - 2442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Despouy, M. Joiner, E. Le Toriellec, R. Weil, and M. H. Stern The TCL1 oncoprotein inhibits activation-induced cell death by impairing PKC{theta} and ERK pathways Blood, December 15, 2007; 110(13): 4406 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kanchanapoo, M. Ao, R. Prasad, C. Moore, C. Kay, P. Piyachaturawat, and M. C. Rao Role of protein kinase C-{delta} in the age-dependent secretagogue action of bile acids in mammalian colon Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1851 - C1861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Jones, R. E. Stroud, B. S. Kaplan, A. M. Leone, J. E. Bavaria, J. H. Gorman III, R. C. Gorman, and J. S. Ikonomidis Differential Protein Kinase C Isoform Abundance in Ascending Aortic Aneurysms From Patients With Bicuspid Versus Tricuspid Aortic Valves Circulation, September 11, 2007; 116(11_suppl): I-144 - I-149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Podar, M. S. Raab, J. Zhang, D. McMillin, I. Breitkreutz, Y.-T. Tai, B. K. Lin, N. Munshi, T. Hideshima, D. Chauhan, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl) Blood, February 15, 2007; 109(4): 1669 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Grybko, A. T. Pores-Fernando, G. A. Wurth, and A. Zweifach Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the {theta} isoform does not play a preferential role J. Leukoc. Biol., February 1, 2007; 81(2): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Manicassamy and Z. Sun The Critical Role of Protein Kinase C-{theta} in Fas/Fas Ligand-Mediated Apoptosis J. Immunol., January 1, 2007; 178(1): 312 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Garaude, S. Cherni, S. Kaminski, E. Delepine, C. Chable-Bessia, M. Benkirane, J. Borges, A. Pandiella, M. A. Iniguez, M. Fresno, et al. ERK5 Activates NF-{kappa}B in Leukemic T Cells and Is Essential for Their Growth In Vivo J. Immunol., December 1, 2006; 177(11): 7607 - 7617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Godeny and P. P. Sayeski ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKC{zeta}-controlled ERK1/2 activity within the nucleus Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1297 - C1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Renault-Mihara, F. Beuvon, X. Iturrioz, B. Canton, S. De Bouard, N. Leonard, S. Mouhamad, A. Sharif, J. W. Ramos, M.-P. Junier, et al. Phosphoprotein Enriched in Astrocytes-15 kDa Expression Inhibits Astrocyte Migration by a Protein Kinase C{delta}-dependent Mechanism Mol. Biol. Cell, December 1, 2006; 17(12): 5141 - 5152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hayashi and A. Altman Filamin A Is Required for T Cell Activation Mediated by Protein Kinase C-{theta} J. Immunol., August 1, 2006; 177(3): 1721 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Oda, S. Ikari, T. Matsuno, Y. Morimune, M. Nagahama, and J. Sakurai Signal Transduction Mechanism Involved in Clostridium perfringens Alpha-Toxin-Induced Superoxide Anion Generation in Rabbit Neutrophils. Infect. Immun., May 1, 2006; 74(5): 2876 - 2886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ding, C. Huang, Y. Lu, L. Bowman, V. Castranova, and V. Vallyathan Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L291 - L297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Contini, M. Ghio, A. Merlo, A. Poggi, F. Indiveri, and F. Puppo Apoptosis of Antigen-Specific T Lymphocytes upon the Engagement of CD8 by Soluble HLA Class I Molecules Is Fas Ligand/Fas Mediated: Evidence for the Involvement of p56lck, Calcium Calmodulin Kinase II, and Calcium-Independent Protein Kinase C Signaling Pathways and for NF-{kappa}B and NF-AT Nuclear Translocation J. Immunol., December 1, 2005; 175(11): 7244 - 7254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Marshall, D. Salerno, J. Garriga, and X. Grana Cyclin T1 Expression Is Regulated by Multiple Signaling Pathways and Mechanisms during Activation of Human Peripheral Blood Lymphocytes J. Immunol., November 15, 2005; 175(10): 6402 - 6411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-A. Park, F. He, L. D. Martin, Y. Li, B. N. Chorley, and K. B. Adler Human Neutrophil Elastase Induces Hypersecretion of Mucin from Well-Differentiated Human Bronchial Epithelial Cells in Vitro via a Protein Kinase C{delta}-Mediated Mechanism Am. J. Pathol., September 1, 2005; 167(3): 651 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gulow, M. Kaminski, K. Darvas, D. Suss, M. Li-Weber, and P. H. Krammer HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death J. Immunol., May 1, 2005; 174(9): 5249 - 5260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cippitelli, C. Fionda, D. Di Bona, M. Piccoli, L. Frati, and A. Santoni Hyperthermia Enhances CD95-Ligand Gene Expression in T Lymphocytes J. Immunol., January 1, 2005; 174(1): 223 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Aiba, M. Oh-hora, S. Kiyonaka, Y. Kimura, A. Hijikata, Y. Mori, and T. Kurosaki Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation PNAS, November 23, 2004; 101(47): 16612 - 16617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. N. Berg-Brown, M. A. Gronski, R. G. Jones, A. R. Elford, E. K. Deenick, B. Odermatt, D. R. Littman, and P. S. Ohashi PKC{theta} Signals Activation versus Tolerance In Vivo J. Exp. Med., March 15, 2004; 199(6): 743 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pardo, M. Buferne, M.-J. Martinez-Lorenzo, J. Naval, A.-M. Schmitt-Verhulst, C. Boyer, and A. Anel Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression Int. Immunol., December 1, 2003; 15(12): 1441 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ishaq, G. DeGray, and V. Natarajan Protein Kinase C{theta} Modulates Nuclear Receptor-Corepressor Interaction during T Cell Activation J. Biol. Chem., October 10, 2003; 278(41): 39296 - 39302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Trushin, K. N. Pennington, E. M. Carmona, S. Asin, D. N. Savoy, D. D. Billadeau, and C. V. Paya Protein Kinase C{alpha} (PKC{alpha}) Acts Upstream of PKC{theta} To Activate I{kappa}B Kinase and NF-{kappa}B in T Lymphocytes Mol. Cell. Biol., October 1, 2003; 23(19): 7068 - 7081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Crist, T. S. Griffith, and T. L. Ratliff Structure/Function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element J. Biol. Chem., September 19, 2003; 278(38): 35950 - 35958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Runyan, H. W. Schnaper, and A.-C. Poncelet Smad3 and PKC{delta} mediate TGF-{beta}1-induced collagen I expression in human mesangial cells Am J Physiol Renal Physiol, September 1, 2003; 285(3): F413 - F422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Hock and M. A. Brown Nuclear Factor of Activated T Cells 2 Transactivation in Mast Cells: A NOVEL ISOFORM-SPECIFIC TRANSACTIVATION DOMAIN CONFERS UNIQUE Fc{epsilon}RI RESPONSIVENESS J. Biol. Chem., July 11, 2003; 278(29): 26695 - 26703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Nelson, K. Hellevuo, M. Yoshimura, and B. Tabakoff Ethanol-induced Phosphorylation and Potentiation of the Activity of Type 7 Adenylyl Cyclase. INVOLVEMENT OF PROTEIN KINASE C delta J. Biol. Chem., February 7, 2003; 278(7): 4552 - 4560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. del Pozo, M. A. Schwartz, J. Hu, W. B. Kiosses, A. Altman, and M. Villalba Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreading J. Immunol., January 1, 2003; 170(1): 41 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mukherjee, P. K. Maiti, and D. Nandi Role of CD80, CD86, and CTLA4 on mouse CD4+ T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin J. Leukoc. Biol., November 1, 2002; 72(5): 921 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Chwae, M. J. Chang, S. M. Park, H. Yoon, H.-J. Park, S. J. Kim, and J. Kim Molecular Mechanism of the Activation-Induced Cell Death Inhibition Mediated by a p70 Inhibitory Killer Cell Ig-Like Receptor in Jurkat T Cells J. Immunol., October 1, 2002; 169(7): 3726 - 3735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishaq, M. Fan, K. Wigmore, A. Gaddam, and V. Natarajan Regulation of Retinoid X Receptor Responsive Element-Dependent Transcription in T Lymphocytes by Ser/Thr Phosphatases: Functional Divergence of Protein Kinase C (PKC){theta} and PKC{alpha} in Mediating Calcineurin-Induced Transactivation J. Immunol., July 15, 2002; 169(2): 732 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Villalba, K. Bi, J. Hu, Y. Altman, P. Bushway, E. Reits, J. Neefjes, G. Baier, R. T. Abraham, and A. Altman Translocation of PKC{theta} in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C J. Cell Biol., April 15, 2002; 157(2): 253 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Miller and L. J. Berg Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase J. Immunol., March 1, 2002; 168(5): 2163 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Moise, J. R. Grant, T. Z. Vitalis, and W. A. Jefferies Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release J. Virol., February 15, 2002; 76(4): 1578 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. SIGNORELLI, C. LUBERTO, and Y. A. HANNUN Ceramide inhibition of NF-{kappa}B activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response FASEB J, November 1, 2001; 15(13): 2401 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Krappmann, A. Patke, V. Heissmeyer, and C. Scheidereit B-Cell Receptor- and Phorbol Ester-Induced NF-{kappa}B and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's Mol. Cell. Biol., October 1, 2001; 21(19): 6640 - 6650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Hsieh, K.-H. Sun, C.-Y. Tsai, Y.-Y. Tsai, S.-T. Tsai, D.-F. Huang, S.-H. Han, H.-S. Yu, and C.-L. Yu Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils Rheumatology, August 1, 2001; 40(8): 851 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Villalba, P. Bushway, and A. Altman Protein Kinase C-{{theta}} Mediates a Selective T Cell Survival Signal Via Phosphorylation of BAD J. Immunol., May 15, 2001; 166(10): 5955 - 5963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wang, L. Zhang, X. Zhang, J. Moreno, X. Luo, M. Tondravi, and Y. Shi Differential Regulation of the Expression of CD95 Ligand, Receptor Activator of Nuclear Factor-{{kappa}}B Ligand (RANKL), TNF-Related Apoptosis-Inducing Ligand (TRAIL), and TNF-{{alpha}} During T Cell Activation J. Immunol., February 1, 2001; 166(3): 1983 - 1990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rusnak and P. Mertz Calcineurin: Form and Function Physiol Rev, October 1, 2000; 80(4): 1483 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Ahnadi, P. Giguère, S. Gravel, D. Gagné, A.-C. Goulet, T. Fülöp Jr, M. D. Payet, and G. Dupuis Chronic PMA treatment of Jurkat T lymphocytes results in decreased protein tyrosine phosphorylation and inhibition of CD3- but not Ti-dependent antibody-triggered Ca2+ signaling J. Leukoc. Biol., August 1, 2000; 68(2): 293 - 300. [Abstract] [Full Text]
|
|
|
|
|
|
B. Bauer, N. Krumbock, F. Fresser, F. Hochholdinger, M. Spitaler, A. Simm, F. Uberall, B. Schraven, and G. Baier Complex Formation and Cooperation of Protein Kinase Ctheta and Akt1/Protein Kinase Balpha in the NF-kappa B Transactivation Cascade in Jurkat T Cells J. Biol. Chem., August 17, 2001; 276(34): 31627 - 31634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Coudronniere, M. Villalba, N. Englund, and A. Altman NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta PNAS, March 28, 2000; 97(7): 3394 - 3399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Villalba, K. Bi, J. Hu, Y. Altman, P. Bushway, E. Reits, J. Neefjes, G. Baier, R. T. Abraham, and A. Altman Translocation of PKC{theta} in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C J. Cell Biol., April 15, 2002; 157(2): 253 - 263. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
