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*
Laboratory of Viral Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan;
Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan; and
Department of Pediatrics, Nagoya Ekisaikai Hospital, Nagoya, Japan
The origin of the increased numbers of CD8+ atypical
lymphocytes, expressing activated markers such as HLA-DR or CD45RO, in
the peripheral blood of patients with infectious mononucleosis (IM) has
been debated. Using a recently developed assay to detect intracellular
accumulation of IFN-
in EBV-reactive T cells by FACS, we have
demonstrated that 34–54% of HLA-DR+/CD8+ and
34–60% of CD45RO+/CD8+ T cells in the PBMCs
of febrile patients suffering from IM are EBV-specific. The
EBV-specific CD8+ T cell counts in the PBMCs of four
febrile patients suffering from IM ranged between 2260 and 8200/µl,
decreasing to 5.1% and 7.9% of the counts in the first samples over
10 days in two donors. The decline of CD8+ T cell
subpopulations, namely HLA-DR+, CD45RO+, and
EBV-specific T cells, was in parallel with the drop in the EBV genome
load. These data indicate that the Ag-driven expansion of
CD8+ T cells and subsequent contraction with the Ag decline
in vivo in humans is effective for clearing virus-infected cells with
minimal disturbance of the homeostasis of the immune
system.
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