The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCormick, L. L.
Right arrow Articles by Gilliam, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCormick, L. L.
Right arrow Articles by Gilliam, A. C.
The Journal of Immunology, 1999, 163: 5693-5699.
Copyright © 1999 by The American Association of Immunologists

Anti-TGF-ß Treatment Prevents Skin and Lung Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease: A Model for Human Scleroderma1

Laura L. McCormick, Yan Zhang, Elena Tootell and Anita C. Gilliam2

Department of Dermatology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, OH 44106

Scleroderma, a debilitating acquired connective tissue disease, is characterized by fibrosis, particularly of the skin and lungs. Monocyte-produced TGF-ß1, a potent stimulus for collagen synthesis, is thought to drive the fibrosis. Here, we thoroughly characterize a murine sclerodermatous graft-vs-host disease (Scl GVHD) model for scleroderma that reproduces important features of scleroderma including skin thickening, lung fibrosis, and up-regulation of cutaneous collagen mRNA, which is preceded by monocyte infiltration and the up-regulation of cutaneous TGF-ß1 mRNA. Most importantly, we can prevent fibrosis in both the skin and lungs of mice with Scl GVHD by inhibiting TGF-ß with neutralizing Abs. The murine Scl GVHD model provides the unique opportunity to study basic immunologic mechanisms that drive fibrosing diseases and GVHD itself and will be useful for testing new therapies for these diseases.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
W.S. Bartynski
Posterior Reversible Encephalopathy Syndrome, Part 2: Controversies Surrounding Pathophysiology of Vasogenic Edema
AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1043 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
D. Creamer, C. L. Martyn-Simmons, G. Osborne, M. Kenyon, J. R. Salisbury, S. Devereux, A. Pagliuca, A. Y. Ho, G. J. Mufti, and A. W. P. du Vivier
Eczematoid Graft-vs-Host Disease: A Novel Form of Chronic Cutaneous Graft-vs-Host Disease and Its Response to Psoralen UV-A Therapy
Arch Dermatol, September 1, 2007; 143(9): 1157 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Kim, H. J. Kim, K. Park, J. Kim, H.-J. Choi, H. Yagita, S. H. Nam, H. R. Cho, and B. Kwon
Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease
Blood, July 15, 2007; 110(2): 776 - 782.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Sakoda, D. Hashimoto, S. Asakura, K. Takeuchi, M. Harada, M. Tanimoto, and T. Teshima
Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease
Blood, February 15, 2007; 109(4): 1756 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Agostini and C. Gurrieri
Chemokine/Cytokine cocktail in idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Banovic, K. P. A. MacDonald, E. S. Morris, V. Rowe, R. Kuns, A. Don, J. Kelly, S. Ledbetter, A. D. Clouston, and G. R. Hill
TGF-{beta} in allogeneic stem cell transplantation: friend or foe?
Blood, September 15, 2005; 106(6): 2206 - 2214.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. J. Lee
New approaches for preventing and treating chronic graft-versus-host disease
Blood, June 1, 2005; 105(11): 4200 - 4206.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J.-K. Ryu, S. U. Song, J.-Y. Han, Y.-C. Chu, M. Lee, J.-S. Kim, S.-J. Kim, and J.-K. Suh
Establishment of Penile Fibrosis Model in a Rat Using Mouse NIH 3T3 Fibroblasts Expressing Transforming Growth Factor {beta}1
Biol Reprod, April 1, 2005; 72(4): 916 - 921.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. E. Anderson, J. M. McNiff, D. Jain, B. R. Blazar, W. D. Shlomchik, and M. J. Shlomchik
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ
Blood, March 1, 2005; 105(5): 2227 - 2234.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Arras, J. Louahed, J.-F. Heilier, M. Delos, F. Brombacher, J.-C. Renauld, D. Lison, and F. Huaux
IL-9 Protects against Bleomycin-Induced Lung Injury: Involvement of Prostaglandins
Am. J. Pathol., January 1, 2005; 166(1): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Motomura, H. Kanbayashi, W. I. Khan, Y. Deng, P. A. Blennerhassett, P. J. Margetts, J. Gauldie, K. Egashira, and S. M. Collins
The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-{beta} type II receptor gene transfer
Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G143 - G150.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. H. Kaplan, B. E. Anderson, J. M. McNiff, D. Jain, M. J. Shlomchik, and W. D. Shlomchik
Target Antigens Determine Graft-versus-Host Disease Phenotype
J. Immunol., November 1, 2004; 173(9): 5467 - 5475.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. E. Anderson, J. M. McNiff, C. Matte, I. Athanasiadis, W. D. Shlomchik, and M. J. Shlomchik
Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease
Blood, September 1, 2004; 104(5): 1565 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Lakos, S. Takagawa, S.-J. Chen, A. M. Ferreira, G. Han, K. Masuda, X.-J. Wang, L. A. DiPietro, and J. Varga
Targeted Disruption of TGF-{beta}/Smad3 Signaling Modulates Skin Fibrosis in a Mouse Model of Scleroderma
Am. J. Pathol., July 1, 2004; 165(1): 203 - 217.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Bohm, M. Raghunath, C. Sunderkotter, M. Schiller, S. Stander, T. Brzoska, T. Cauvet, H. B. Schioth, T. Schwarz, and T. A. Luger
Collagen Metabolism Is a Novel Target of the Neuropeptide {alpha}-Melanocyte-stimulating Hormone
J. Biol. Chem., February 20, 2004; 279(8): 6959 - 6966.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
U. Bartram and C. P. Speer
The Role of Transforming Growth Factor {beta} in Lung Development and Disease
Chest, February 1, 2004; 125(2): 754 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Zhang-Hoover and J. Stein-Streilein
Tolerogenic APC Generate CD8+ T Regulatory Cells That Modulate Pulmonary Interstitial Fibrosis
J. Immunol., January 1, 2004; 172(1): 178 - 185.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. S. Razzaque, C. S. Foster, and A. R. Ahmed
Role of Collagen-Binding Heat Shock Protein 47 and Transforming Growth Factor-{beta}1 in Conjunctival Scarring in Ocular Cicatricial Pemphigoid
Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1616 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. C. Chambers, P. Leoni, N. Kaminski, G. J. Laurent, and R. A. Heller
Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-{beta}1 Reveals the Induction of Inhibitor of Differentiation-1 and Provides Evidence of Smooth Muscle Cell Phenotypic Switching
Am. J. Pathol., February 1, 2003; 162(2): 533 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Clin Med ResHome page
K. C. Flanders and J. K. Burmester
Medical Applications of Transforming Growth Factor-{beta}
Clin. Med. Res., January 1, 2003; 1(1): 13 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
A Crilly, J Hamilton, C J Clark, A Jardine, and R Madhok
Analysis of transforming growth factor {beta}1 gene polymorphisms in patients with systemic sclerosis
Ann Rheum Dis, August 1, 2002; 61(8): 678 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Zhang, L. L. McCormick, S. R. Desai, C. Wu, and A. C. Gilliam
Murine Sclerodermatous Graft-Versus-Host Disease, a Model for Human Scleroderma: Cutaneous Cytokines, Chemokines, and Immune Cell Activation
J. Immunol., March 15, 2002; 168(6): 3088 - 3098.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. J. Gross and G. W. Hunninghake
Idiopathic Pulmonary Fibrosis
N. Engl. J. Med., August 16, 2001; 345(7): 517 - 525.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Abe, S. C. Donnelly, T. Peng, R. Bucala, and C. N. Metz
Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
J. Immunol., June 15, 2001; 166(12): 7556 - 7562.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
O. EICKELBERG, A. PANSKY, E. KOEHLER, M. BIHL, M. TAMM, P. HILDEBRAND, A. P. PERRUCHOUD, M. KASHGARIAN, and M. ROTH
Molecular mechanisms of TGF-{beta} antagonism by interferon {gamma} and cyclosporine A in lung fibroblasts
FASEB J, March 1, 2001; 15(3): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Chen, Y. Wei, G. C. Sharp, and H. Braley-Mullen
Characterization of thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis
J. Leukoc. Biol., December 1, 2000; 68(6): 828 - 835.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.