The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Keane, M. P.
Right arrow Articles by Strieter, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Keane, M. P.
Right arrow Articles by Strieter, R. M.
The Journal of Immunology, 1999, 163: 5686-5692.
Copyright © 1999 by The American Association of Immunologists

IFN-{gamma}-Inducible Protein-10 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Angiogenesis1

Michael P. Keane, John A. Belperio, Douglas A. Arenberg, Marie D. Burdick, Zuo J. Xu, Ying Y. Xue and Robert M. Strieter2

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109

Few studies have addressed the importance of vascular remodeling in the lung during the development of bleomycin-induced pulmonary fibrosis (BPF). For fibroplasia and deposition of extracellular matrix to occur, there must be a geometric increase in neovascularization. We hypothesized that net angiogenesis during the pathogenesis of fibroplasia and deposition of extracellular matrix during BPF are dependent in part on a relative deficiency of the angiostatic CXC chemokine, IFN-{gamma}-inducible protein-10 (IP-10). To test this hypothesis, we measured IP-10 by specific ELISA in whole lung homogenates in either bleomycin-treated or control mice and correlated these levels with lung hydroxyproline. We found that lung tissue from mice treated with bleomycin, compared with that from saline-treated controls, demonstrated a decrease in the presence of IP-10 that was correlated to a greater angiogenic response and total lung hydroxyproline content. Systemic administration of IP-10 significantly reduced BPF without any alteration in lung lymphocyte or NK cell populations. This was also paralleled by a reduction in angiogenesis. Furthermore, IP-10 had no direct effect on isolated pulmonary fibroblasts. These results demonstrate that the angiostatic CXC chemokine, IP-10, inhibits fibroplasia and deposition of extracellular matrix by regulating angiogenesis.




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. A. Scheibner, S. Boodoo, S. Collins, K. E. Black, Y. Chan-Li, P. Zarek, J. D. Powell, and M. R. Horton
The Adenosine A2a Receptor Inhibits Matrix-Induced Inflammation in a Novel Fashion
Am. J. Respir. Cell Mol. Biol., March 1, 2009; 40(3): 251 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Anticancer ResHome page
F. RECCHIA, G. CANDELORO, S. NECOZIONE, R. BISEGNA, M. BRATTA, and S. REA
Immunotherapy in Patients with Less than Complete Response to Chemotherapy
Anticancer Res, February 1, 2009; 29(2): 567 - 572.
[Abstract] [Full Text] [PDF]

Home page
 ACCP Pulmonary Med Brd RevHome page
J. P. Lynch III
Idiopathic Pulmonary Fibrosis, Nonspecific Interstitial Pneumonia/Fibrosis, and Sarcoidosis
ACCP Pulmonary Med Brd Rev, January 1, 2009; 25(0): 635 - 686.
[Full Text] [PDF]

Home page
 ERRHome page
M. P. Keane
The role of chemokines and cytokines in lung fibrosis
Eur. Respir. Rev., December 1, 2008; 17(109): 151 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
E. C. Keeley, B. Mehrad, and R. M. Strieter
Chemokines as Mediators of Neovascularization
Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1928 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Antao-Menezes, E. A. Turpin, P. C. Bost, J. P. Ryman-Rasmussen, and J. C. Bonner
STAT-1 Signaling in Human Lung Fibroblasts Is Induced by Vanadium Pentoxide through an IFN-{beta} Autocrine Loop
J. Immunol., March 15, 2008; 180(6): 4200 - 4207.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. W. Hunninghake and M. I. Schwarz
State of the Art. Does Current Knowledge Explain the Pathogenesis of Idiopathic Pulmonary Fibrosis?: A Perspective
Proceedings of the ATS, August 15, 2007; 4(5): 449 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. Kass, R. S. Bridges, A. Borczuk, and S. Greenberg
Methionine Aminopeptidase-2 as a Selective Target of Myofibroblasts in Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., August 1, 2007; 37(2): 193 - 201.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. L. Mora, E. Torres-Gonzalez, M. Rojas, J. Xu, J. Ritzenthaler, S. H. Speck, J. Roman, K. Brigham, and A. Stecenko
Control of Virus Reactivation Arrests Pulmonary Herpesvirus-induced Fibrosis in IFN-{gamma} Receptor-deficient Mice
Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1139 - 1150.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Ishida, A. Kimura, T. Kondo, T. Hayashi, M. Ueno, N. Takakura, K. Matsushima, and N. Mukaida
Essential Roles of the CC Chemokine Ligand 3-CC Chemokine Receptor 5 Axis in Bleomycin-Induced Pulmonary Fibrosis through Regulation of Macrophage and Fibrocyte Infiltration
Am. J. Pathol., March 1, 2007; 170(3): 843 - 854.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. M. Antoniou, A. Tzouvelekis, M. G. Alexandrakis, K. Sfiridaki, I. Tsiligianni, G. Rachiotis, N. Tzanakis, D. Bouros, J. Milic-Emili, and N. M. Siafakas
Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
Chest, October 1, 2006; 130(4): 982 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Boodoo, E. W. Spannhake, J. D. Powell, and M. R. Horton
Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L479 - L486.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Pan, M. D. Burdick, J. A. Belperio, Y. Y. Xue, C. Gerard, S. Sharma, S. M. Dubinett, and R. M. Strieter
CXCR3/CXCR3 Ligand Biological Axis Impairs RENCA Tumor Growth by a Mechanism of Immunoangiostasis
J. Immunol., February 1, 2006; 176(3): 1456 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. Agostini and C. Gurrieri
Chemokine/Cytokine cocktail in idiopathic pulmonary fibrosis.
Proceedings of the ATS, January 1, 2006; 3(4): 357 - 363.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Mestas, M. D. Burdick, K. Reckamp, A. Pantuck, R. A. Figlin, and R. M. Strieter
The Role of CXCR2/CXCR2 Ligand Biological Axis in Renal Cell Carcinoma
J. Immunol., October 15, 2005; 175(8): 5351 - 5357.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Chen, Y. Wei, A. Alter, G. C. Sharp, and H. Braley-Mullen
Chemokine expression during development of fibrosis versus resolution in a murine model of granulomatous experimental autoimmune thyroiditis
J. Leukoc. Biol., September 1, 2005; 78(3): 716 - 724.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Hamada, K. Kuwano, M. Yamada, N. Hagimoto, K. Hiasa, K. Egashira, N. Nakashima, T. Maeyama, M. Yoshimi, and Y. Nakanishi
Anti-Vascular Endothelial Growth Factor Gene Therapy Attenuates Lung Injury and Fibrosis in Mice
J. Immunol., July 15, 2005; 175(2): 1224 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. C.J. Howell, R. H. Johns, J. A. Lasky, B. Shan, C. J. Scotton, G. J. Laurent, and R. C. Chambers
Absence of Proteinase-Activated Receptor-1 Signaling Affords Protection from Bleomycin-Induced Lung Inflammation and Fibrosis
Am. J. Pathol., May 1, 2005; 166(5): 1353 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. D. Burdick, L. A. Murray, M. P. Keane, Y. Y. Xue, D. A. Zisman, J. A. Belperio, and R. M. Strieter
CXCL11 Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 261 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. M. Tager, R. L. Kradin, P. LaCamera, S. D. Bercury, G. S. V. Campanella, C. P. Leary, V. Polosukhin, L.-H. Zhao, H. Sakamoto, T. S. Blackwell, et al.
Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10
Am. J. Respir. Cell Mol. Biol., October 1, 2004; 31(4): 395 - 404.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Belperio, M. Dy, L. Murray, M. D. Burdick, Y. Y. Xue, R. M. Strieter, and M. P. Keane
The Role of the Th2 CC Chemokine Ligand CCL17 in Pulmonary Fibrosis
J. Immunol., October 1, 2004; 173(7): 4692 - 4698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. P. Keane
Angiogenesis and Pulmonary Fibrosis: Feast or Famine?
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 207 - 209.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. P. Cosgrove, K. K. Brown, W. P. Schiemann, A. E. Serls, J. E. Parr, M. W. Geraci, M. I. Schwarz, C. D. Cool, and G. S. Worthen
Pigment Epithelium-derived Factor in Idiopathic Pulmonary Fibrosis: A Role in Aberrant Angiogenesis
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 242 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. H. Dauber, K. F. Gibson, and N. Kaminski
Interferon-{gamma} 1b in Idiopathic Pulmonary Fibrosis: What We Know and What Must We Learn
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 107 - 108.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. Strieter, K. M. Starko, R. I. Enelow, I. Noth, V. G. Valentine, and the other members of the Idiopathic Pulmonary Fibr
Effects of Interferon-{gamma} 1b on Biomarker Expression in Patients with Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 133 - 140.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
N R Simler, P E Brenchley, A W Horrocks, S M Greaves, P S Hasleton, and J J Egan
Angiogenic cytokines in patients with idiopathic interstitial pneumonia
Thorax, July 1, 2004; 59(7): 581 - 585.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. A. Renzoni
Neovascularization in Idiopathic Pulmonary Fibrosis: Too Much or too Little?
Am. J. Respir. Crit. Care Med., June 1, 2004; 169(11): 1179 - 1180.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Keane, J. A. Belperio, Y. Y. Xue, M. D. Burdick, and R. M. Strieter
Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer
J. Immunol., March 1, 2004; 172(5): 2853 - 2860.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al.
Idiopathic Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Jakubzick, E. S. Choi, B. H. Joshi, M. P. Keane, S. L. Kunkel, R. K. Puri, and C. M. Hogaboam
Therapeutic Attenuation of Pulmonary Fibrosis Via Targeting of IL-4- and IL-13-Responsive Cells
J. Immunol., September 1, 2003; 171(5): 2684 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Mukaida
Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases
Am J Physiol Lung Cell Mol Physiol, April 1, 2003; 284(4): L566 - L577.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. G. Kallapur, A. H. Jobe, M. Ikegami, and C. J. Bachurski
Increased IP-10 and MIG Expression after Intra-amniotic Endotoxin in Preterm Lamb Lung
Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 779 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. A. Renzoni, D. A. Walsh, M. Salmon, A. U. Wells, P. Sestini, A. G. Nicholson, S. Veeraraghavan, A. E. Bishop, H. M. Romanska, P. Pantelidis, et al.
Interstitial Vascularity in Fibrosing Alveolitis
Am. J. Respir. Crit. Care Med., February 1, 2003; 167(3): 438 - 443.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Keane, S. C. Donnelly, J. A. Belperio, R. B. Goodman, M. Dy, M. D. Burdick, M. C. Fishbein, and R. M. Strieter
Imbalance in the Expression of CXC Chemokines Correlates with Bronchoalveolar Lavage Fluid Angiogenic Activity and Procollagen Levels in Acute Respiratory Distress Syndrome
J. Immunol., December 1, 2002; 169(11): 6515 - 6521.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. M. Strieter, J. A. Belperio, and M. P. Keane
CXC Chemokines in Angiogenesis Related to Pulmonary Fibrosis
Chest, December 1, 2002; 122 (2009): 298S - 301S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. A. Belperio, M. Dy, M. D. Burdick, Y. Y. Xue, K. Li, J. A. Elias, and M. P. Keane
Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 419 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Zhu, B. Ma, T. Zheng, R. J. Homer, C. G. Lee, I. F. Charo, P. Noble, and J. A. Elias
IL-13-Induced Chemokine Responses in the Lung: Role of CCR2 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling
J. Immunol., March 15, 2002; 168(6): 2953 - 2962.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. P. KEANE, J. A. BELPERIO, M. D. BURDICK, J. P. LYNCH III, M. C. FISHBEIN, and R. M. STRIETER
ENA-78 Is an Important Angiogenic Factor in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2239 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Q. Zhao, M. K. Amir, W. R. Rice, and R. I. Enelow
Type II Pneumocyte-CD8+ T-Cell Interactions . Relationship between Target Cell Cytotoxicity and Activation
Am. J. Respir. Cell Mol. Biol., September 1, 2001; 25(3): 362 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. P. Keane, J. A. Belperio, M. D. Burdick, and R. M. Strieter
IL-12 attenuates bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L92 - L97.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Ebrahimi, B. M. Dutia, D. G. Brownstein, and A. A. Nash
Murine Gammaherpesvirus-68 Infection Causes Multi-Organ Fibrosis and Alters Leukocyte Trafficking in Interferon-{{gamma}} Receptor Knockout Mice
Am. J. Pathol., June 1, 2001; 158(6): 2117 - 2125.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Recchia, S. De Filippis, M. Rosselli, G. Saggio, A. Cesta, L. Fumagalli, and S. Rea
Phase 1B Study of Subcutaneously Administered Interleukin 2 in Combination with 13-cis Retinoic Acid as Maintenance Therapy in Advanced Cancer
Clin. Cancer Res., May 1, 2001; 7(5): 1251 - 1257.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. Choi, X. Xu, J.-W. Oh, S. J. Lee, G. Y. Gillespie, H. Park, H. Jo, and E. N. Benveniste
Fas-induced Expression of Chemokines in Human Glioma Cells: Involvement of Extracellular Signal-regulated Kinase 1/2 and p38 Mitogen-activated Protein Kinase
Cancer Res., April 1, 2001; 61(7): 3084 - 3091.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. T. Liu, D. Armstrong, T. A. Hamilton, and T. E. Lane
Expression of Mig (Monokine Induced by Interferon-{{gamma}}) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System
J. Immunol., February 1, 2001; 166(3): 1790 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Itakura, A. Tokuda, H. Kimura, S. Nagai, H. Yoneyama, N. Onai, S. Ishikawa, T. Kuriyama, and K. Matsushima
Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates Propionibacterium acnes-Induced Acute Lung Inflammation
J. Immunol., February 1, 2001; 166(3): 2071 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
M. Selman, T. E. King Jr., and A. Pardo
Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy
Ann Intern Med, January 16, 2001; 134(2): 136 - 151.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. T. Liu, B. P. Chen, P. Oertel, M. J. Buchmeier, D. Armstrong, T. A. Hamilton, and T. E. Lane
Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease
J. Immunol., September 1, 2000; 165(5): 2327 - 2330.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. C. Fang
Mesenchymal Regulation of Alveolar Repair in Pulmonary Fibrosis
Am. J. Respir. Cell Mol. Biol., August 1, 2000; 23(2): 142 - 145.
[Full Text]

Home page
 J. Leukoc. Biol.Home page
J. A. Belperio, M. P. Keane, D. A. Arenberg, C. L. Addison, J. E. Ehlert, M. D. Burdick, and R. M. Strieter
CXC chemokines in angiogenesis
J. Leukoc. Biol., July 1, 2000; 68(1): 1 - 8.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.