| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
In the absence of therapy that suppresses the action of the immune system, the immune response to transplantation Ags results in rapid rejection of the transplant. The most successful mechanism so far described that achieves organ-specific immunological tolerance is that which controls peripheral tolerance to self-tissue. Until now, no similarities have been documented between the peripheral response to self-Ags and the response to transplantation Ags. CD4+ cells that express a high density of CD45RB (in the mouse) and CD45RC (in the rat) on their surface have been shown to cause a number of autoimmune disorders. In contrast, autoimmunity caused by the CD45RB high-density cells is inhibited by CD4+ CD45RB cells that express a low density of CD45RB (CD45RC in the rat). In this paper we show that CD4+ CD45RB high-density cells are sufficient to cause rejection of a MHC-mismatched pancreas allograft, whereas CD4+ CD45RB low-density cells are not. Unexpectedly, the CD45RB low-density cells prevent the CD45RBhigh expressing cells from causing rejection. These data suggest that the response to foreign tissue can be controlled in the same way as the response to self-tissue.
This article has been cited by other articles:
|
|
 |
|
  K. Y. Jen, M. Campo, H. He, S. S. Makani, G. Velasco, D. M. Rothstein, D. L. Perkins, and P. W. Finn CD45RB Ligation Inhibits Allergic Pulmonary Inflammation by Inducing CTLA4 Transcription J. Immunol., September 15, 2007; 179(6): 4212 - 4218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chen, N. Zhang, S. Fu, B. Schroppel, Q. Guo, A. Garin, S. A. Lira, and J. S. Bromberg CD4+CD25+ Regulatory T-Cells Inhibit the Islet Innate Immune Response and Promote Islet Engraftment. Diabetes, April 1, 2006; 55(4): 1011 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sanchez-Fueyo, S. Sandner, A. Habicht, C. Mariat, J. Kenny, N. Degauque, X. X. Zheng, T. B. Strom, L. A. Turka, and M. H. Sayegh Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity J. Immunol., January 1, 2006; 176(1): 329 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. V. Aruna, M. Sela, and E. Mozes Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells PNAS, July 19, 2005; 102(29): 10285 - 10290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Rushbrook, S. M. Ward, E. Unitt, S. L. Vowler, M. Lucas, P. Klenerman, and G. J. M. Alexander Regulatory T Cells Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Persistent Hepatitis C Virus Infection J. Virol., June 15, 2005; 79(12): 7852 - 7859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gregori, P. Mangia, R. Bacchetta, E. Tresoldi, F. Kolbinger, C. Traversari, J. M. Carballido, J. E. de Vries, U. Korthauer, and M.-G. Roncarolo An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells J. Exp. Med., April 18, 2005; 201(8): 1293 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Smart, P. S. Foster, M. E. Rothenberg, T. J. V. Higgins, and S. P. Hogan A Plant-Based Allergy Vaccine Suppresses Experimental Asthma Via an IFN-{gamma} and CD4+CD45RBlow T Cell-Dependent Mechanism J. Immunol., August 15, 2003; 171(4): 2116 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Molano, A. Pileggi, T. Berney, R. Poggioli, E. Zahr, R. Oliver, C. Ricordi, D. M. Rothstein, G. P. Basadonna, and L. Inverardi Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154 Diabetes, April 1, 2003; 52(4): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Sutherland, B. S. McKenzie, Y. Zhan, A. J. Corbett, A. Fox-Marsh, H. M. Georgiou, L. C. Harrison, and A. M. Lew Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing Int. Immunol., August 1, 2002; 14(8): 953 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Graca, S. Thompson, C.-Y. Lin, E. Adams, S. P. Cobbold, and H. Waldmann Both CD4+CD25+ and CD4+CD25- Regulatory Cells Mediate Dominant Transplantation Tolerance J. Immunol., June 1, 2002; 168(11): 5558 - 5565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sanchez-Fueyo, M. Weber, C. Domenig, T. B. Strom, and X. X. Zheng Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance J. Immunol., March 1, 2002; 168(5): 2274 - 2281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. I. Kingsley, M. Karim, A. R. Bushell, and K. J. Wood CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses J. Immunol., February 1, 2002; 168(3): 1080 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Ng, P. J. Duggan, F. Ponchel, G. Matarese, G. Lombardi, A. D. Edwards, J. D. Isaacs, and R. I. Lechler Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells Blood, November 1, 2001; 98(9): 2736 - 2744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hara, C. I. Kingsley, M. Niimi, S. Read, S. E. Turvey, A. R. Bushell, P. J. Morris, F. Powrie, and K. J. Wood IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo J. Immunol., March 15, 2001; 166(6): 3789 - 3796. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
