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*
Division of Immunology and Rheumatology, Department of Medicine, Stanford Medical School, Stanford, CA 94305;
Department of Hematology and Oncology, Beth Israel Deaconess Medical Center, and
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215; and
§
CREST and Department of Molecular Immunology, Chiba University Graduate School of Medicine, Chiba, Japan
NK1.1+ T cells in the mouse thymus and bone marrow were
compared because some marrow NK1.1+ T cells have been
reported to be extrathymically derived. Almost all NK1.1+ T
cells in the thymus were depleted in the CD1-/-,
ß2m-/-, and
J
281-/- mice as compared with wild-type
mice. CD8+NK1.1+ T cells were not clearly
detected, even in the wild-type mice. In bone marrow from the wild-type
mice, CD8+NK1.1+ T cells were easily detected,
about twice as numerous as CD4+NK1.1+ T cells,
and were similar in number to
CD4-CD8-NK1.1+ T cells. All three
marrow NK1.1+ T cell subsets were reduced about 4-fold in
CD1-/- mice. No reduction was observed in
CD8+NK1.1+ T cells in the bone marrow of
J281-/- mice, but marrow
CD8+NK1.1+ T cells were markedly depleted in
ß2m-/- mice. All NK1.1+ T cell
subsets in the marrow of wild-type mice produced high levels of
IFN-
, IL-4, and IL-10. Although the numbers of marrow
CD4-CD8-NK1.1+ T cells in
ß2m-/- and
J281-/- mice were similar to those in
wild-type mice, these cells had a Th1-like pattern (high IFN-, and
low IL-4 and IL-10). In conclusion, the large majority of
NK1.1+ T cells in the bone marrow are CD1 dependent. Marrow
NK1.1+ T cells include CD8+,
V14-J281-, and
ß2m-independent subsets that are not clearly detected in
the thymus.
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