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*
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115; and
Department of Medicine, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02115
NK cells have been shown to play a role in the modulation of B cell
differentiation and Ab production. Using a novel murine model of NK
cell deficiency, we analyzed the in vivo role of NK cells in the
regulation of Ag-specific Ab production. After immunization with OVA or
keyhole limpet hemocyanin in CFA, NK cell-deficient
(NK-T+) mice developed an efficient Th1
response and produced significant levels of IFN-
but displayed
markedly reduced or absent Ag-specific IgG2a production. There were no
differences in the levels of Ag-specific IgG, IgG1, and IgG2b between
NK-T+ and NK+T+ mice.
Furthermore, NK cell-reconstituted, NK+T+
(tg
26Y) mice produced significant amounts of Ag-specific IgG2a after
immunization with OVA. These results indicate that NK cells are
involved in the induction of Ag-specific IgG2a production in vivo.
Moreover, they also demonstrate that the lack of Ag-specific IgG2a Ab
production in NK-T+ mice is not associated
with the impaired Th1 response and IFN-
production.
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