| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC 27858
T cell expression of class II MHC/peptide complexes may be
important for maintenance of peripheral self-tolerance, but mechanisms
underlying the genesis of class II MHC glycoproteins on T cells are not
well resolved. T cell APC (T-APC) used herein were transformed
IL-2-dependent clones that constitutively synthesized class II MHC
glycoproteins. When pulsed with myelin basic protein (MBP) and injected
into Lewis rats, these T-APC reduced the severity of experimental
autoimmune encephalomyelitis, whereas unpulsed T-APC were without
activity. Normal MBP-reactive clones cultured without APC did not
express class II MHC even when activated with mitogens and exposed to
IFN-
. However, during a 4-h culture with T-APC or macrophage APC,
recognition of MBP or mitogenic activation of responder T cells
elicited high levels of I-A and I-E expression on responders.
Acquisition of class II MHC glycoproteins by responders was resistant
to the protein synthesis inhibitor cycloheximide, coincided with
transfer of a PKH26 lipophilic dye from APC to responders, and resulted
in the expression of syngeneic and allogeneic MHC glycoproteins on
responders. Unlike rested I-A- T cell clones, rat thymic
and splenic T cells expressed readily detectable levels of class II MHC
glycoproteins. When preactivated with mitogens, naive T cells acquired
APC-derived MHC class II molecules and other membrane-associated
proteins when cultured with xenogeneic APC in the absence of Ag. In
conclusion, this study provides evidence that APC donate membrane-bound
peptide/MHC complexes to Ag-specific T cell responders by a mechanism
associated with the induction of tolerance.
This article has been cited by other articles:
|
|
 |
|
  A. Busch, T. Quast, S. Keller, W. Kolanus, P. Knolle, P. Altevogt, and A. Limmer Transfer of T Cell Surface Molecules to Dendritic Cells upon CD4+ T Cell Priming Involves Two Distinct Mechanisms J. Immunol., September 15, 2008; 181(6): 3965 - 3973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Machlenkin, R. Uzana, S. Frankenburg, G. Eisenberg, L. Eisenbach, J. Pitcovski, R. Gorodetsky, A. Nissan, T. Peretz, and M. Lotem Capture of Tumor Cell Membranes by Trogocytosis Facilitates Detection and Isolation of Tumor-Specific Functional CTLs Cancer Res., March 15, 2008; 68(6): 2006 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hao, J. Yuan, and J. Xiang Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory J. Leukoc. Biol., October 1, 2007; 82(4): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Mannie and D. J. Abbott A Fusion Protein Consisting of IL-16 and the Encephalitogenic Peptide of Myelin Basic Protein Constitutes an Antigen-Specific Tolerogenic Vaccine That Inhibits Experimental Autoimmune Encephalomyelitis J. Immunol., August 1, 2007; 179(3): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Cox, A. J. McMichael, G. R. Screaton, and X.-N. Xu CTLs Target Th Cells That Acquire Bystander MHC Class I-Peptide Complex from APCs J. Immunol., July 15, 2007; 179(2): 830 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hudrisier, A. Aucher, A.-L. Puaux, C. Bordier, and E. Joly Capture of Target Cell Membrane Components via Trogocytosis Is Triggered by a Selected Set of Surface Molecules on T or B Cells J. Immunol., March 15, 2007; 178(6): 3637 - 3647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Mannie, B. A. Clayson, E. J. Buskirk, J. L. DeVine, J. J. Hernandez, and D. J. Abbott IL-2/Neuroantigen Fusion Proteins as Antigen-Specific Tolerogens in Experimental Autoimmune Encephalomyelitis (EAE): Correlation of T Cell-Mediated Antigen Presentation and Tolerance Induction J. Immunol., March 1, 2007; 178(5): 2835 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. LeMaoult, J. Caumartin, M. Daouya, B. Favier, S. L. Rond, A. Gonzalez, and E. D. Carosella Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells Blood, March 1, 2007; 109(5): 2040 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi, S. Hao, T. Chan, and J. Xiang CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion J. Leukoc. Biol., December 1, 2006; 80(6): 1354 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Singleton, N. Parvaze, K. R. Dama, K. S. Chen, P. Jennings, B. Purtic, M. D. Sjaastad, C. Gilpin, M. M. Davis, and C. Wulfing A Large T Cell Invagination with CD2 Enrichment Resets Receptor Engagement in the Immunological Synapse J. Immunol., October 1, 2006; 177(7): 4402 - 4413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Whale, H. L. Wilson, S. K. Tikoo, L. A. Babiuk, and P. J. Griebel Passively acquired membrane proteins alter the functional capacity of bovine polymorphonuclear cells J. Leukoc. Biol., September 1, 2006; 80(3): 481 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bourbie-Vaudaine, N. Blanchard, C. Hivroz, and P.-H. Romeo Dendritic Cells Can Turn CD4+ T Lymphocytes into Vascular Endothelial Growth Factor-Carrying Cells by Intercellular Neuropilin-1 Transfer J. Immunol., August 1, 2006; 177(3): 1460 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Whale, T. K. Beskorwayne, L. A. Babiuk, and P. J. Griebel Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells J. Leukoc. Biol., June 1, 2006; 79(6): 1226 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kolegraff, P. Bostik, and A. A. Ansari Characterization and role of lentivirus-associated host proteins. Experimental Biology and Medicine, March 1, 2006; 231(3): 252 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xiang, H. Huang, and Y. Liu A New Dynamic Model of CD8+ T Effector Cell Responses via CD4+ T Helper-Antigen-Presenting Cells J. Immunol., June 15, 2005; 174(12): 7497 - 7505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fischer, S. Voelkl, J. Heymann, G. K. Przybylski, K. Mondal, M. Laumer, L. Kunz-Schughart, C. A. Schmidt, R. Andreesen, and A. Mackensen Isolation and characterization of human antigen-specific TCR{alpha}{beta}+ CD4-CD8- double-negative regulatory T cells Blood, April 1, 2005; 105(7): 2828 - 2835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Poupot, F. Pont, and J.-J. Fournie Profiling Blood Lymphocyte Interactions with Cancer Cells Uncovers the Innate Reactivity of Human {gamma}{delta} T Cells to Anaplastic Large Cell Lymphoma J. Immunol., February 1, 2005; 174(3): 1717 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Wetzel, T. W. McKeithan, and D. C. Parker Peptide-Specific Intercellular Transfer of MHC Class II to CD4+ T Cells Directly from the Immunological Synapse upon Cellular Dissociation J. Immunol., January 1, 2005; 174(1): 80 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. B. Herrera, D. Golshayan, R. Tibbott, F. S. Ochoa, M. J. James, F. M. Marelli-Berg, and R. I. Lechler A Novel Pathway of Alloantigen Presentation by Dendritic Cells J. Immunol., October 15, 2004; 173(8): 4828 - 4837. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Undale, P. J. van den Elsen, and E. Celis Antigen-independent acquisition of MHC class II molecules by human T lymphocytes Int. Immunol., October 1, 2004; 16(10): 1523 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Andre, N. Chaput, N. E. C. Schartz, C. Flament, N. Aubert, J. Bernard, F. Lemonnier, G. Raposo, B. Escudier, D.-H. Hsu, et al. Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells J. Immunol., February 15, 2004; 172(4): 2126 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Maxwell, R. J. Rossi, S. J. McSorley, and A. T. Vella T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation J. Immunol., January 1, 2004; 172(1): 248 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hwang, X. Shen, and J. Sprent Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules PNAS, May 27, 2003; 100(11): 6670 - 6675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. S. Tsang, J. G. Chai, and R. Lechler Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion? Blood, April 1, 2003; 101(7): 2704 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. HUDRISIER and P. BONGRAND Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance FASEB J, April 1, 2002; 16(6): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Giuntoli II, J. Lu, H. Kobayashi, R. Kennedy, and E. Celis Direct Costimulation of Tumor-reactive CTL by Helper T Cells Potentiate Their Proliferation, Survival, and Effector Function Clin. Cancer Res., March 1, 2002; 8(3): 922 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Carlin, K. Eleme, F. E. McCann, and D. M. Davis Intercellular Transfer and Supramolecular Organization of Human Leukocyte Antigen C at Inhibitory Natural Killer Cell Immune Synapses J. Exp. Med., November 19, 2001; 194(10): 1507 - 1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sjostrom, M. Eriksson, C. Cerboni, M. H. Johansson, C. L. Sentman, K. Karre, and P. Hoglund Acquisition of External Major Histocompatibility Complex Class I Molecules by Natural Killer Cells Expressing Inhibitory Ly49 Receptors J. Exp. Med., November 19, 2001; 194(10): 1519 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Mannie and M. R. Walker Feedback activation of T-cell antigen-presenting cells during interactions with T-cell responders J. Leukoc. Biol., August 1, 2001; 70(2): 252 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hwang and J. Sprent Role of the Actin Cytoskeleton in T Cell Absorption and Internalization of Ligands from APC J. Immunol., April 15, 2001; 166(8): 5099 - 5107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hudrisier, J. Riond, H. Mazarguil, J. E. Gairin, and E. Joly Cutting Edge: CTLs Rapidly Capture Membrane Fragments from Target Cells in a TCR Signaling-Dependent Manner J. Immunol., March 15, 2001; 166(6): 3645 - 3649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Harshyne, S. C. Watkins, A. Gambotto, and S. M. Barratt-Boyes Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL J. Immunol., March 15, 2001; 166(6): 3717 - 3723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lombardi, P. J. Dunne, D. Scheel-Toellner, T. Sanyal, D. Pilling, L. S. Taams, P. Life, J. M. Lord, M. Salmon, and A. N. Akbar Type 1 IFN Maintains the Survival of Anergic CD4+ T Cells J. Immunol., October 1, 2000; 165(7): 3782 - 3789. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
