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Increased Apoptosis in Patients with Major Depression: A Preliminary Study

Eran Eilat, Shlomo Mendlovic^1,*, Adiel Doron^*, Vera Zakuth and Zvi Spirer

^* "Shalvata" Mental Health Center, Hod Hasharon, Israel; and The Leon-Alkalai Chair in Pediatric Immunology, Sackler School of Medicine, and the Dana’s Children Hospital, Tel-Aviv, Israel.

Apoptosis is a programmed cell death that can be observed in normal cells. Major depression poses a combination of a depressed and destructive autoimmune reaction. We measured apoptosis in the PBLs of seven patients with major depression and in age- and sex-matched controls. We observed significantly increased apoptosis in the PBLs of depressive patients (p < 0.05). These preliminary results could contribute to an understanding of the interactions of the CNS with the immune system, which could lead to the increased vulnerability of the CNS in depressive disorders. Further studies are needed to establish these results.

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