| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland;
Clinic for Dermatology and Allergy, Davos, Switzerland; and
Zürcher Höhenklinik Clavadel, Davos, Switzerland
In allergic inflammations of the skin, activation of CD4+ T cells was demonstrated to play an important role; however, a minor role for CD8+ T cells is implied. In the present study, we compared cutaneous lymphocyte-associated Ag (CLA)-expressing CD4+ and CD8+ subsets, which were isolated from peripheral blood and lesional skin biopsies in atopic dermatitis (AD) patients. We demonstrated that CD8+CLA+ T cells proliferate in response to superantigen and are as potent as CD4+CLA+ T cells in IgE induction and support of eosinophil survival. In atopic skin inflammation, the existence of high numbers of CD4+ and CD8+ T cells was demonstrated by immunohistochemistry and by culturing T cells from skin biopsies. In peripheral blood, both CD4+ and CD8+ subsets of CLA+CD45RO+ T cells were in an activated state in AD. The in vivo-activated CLA+ T cells of both subsets spontaneously released an IL-5- and IL-13-dominated Th2 type cytokine pattern. This was confirmed by intracytoplasmic cytokine staining immediately after isolation of the cells from peripheral blood. In consequence, both CD4+ and CD8+, CLA+ memory/effector T cells induced IgE production by B cells mainly by IL-13, and enhanced eosinophil survival in vitro by delaying eosinophil apoptosis, mainly by IL-5. These results indicate that in addition to the CD4+ subset, the CD8+CLA+ memory/effector T cells are capable of responding to superantigenic stimulation and play an important role in the pathogenesis of AD.
This article has been cited by other articles:
|
|
 |
|
  A. Hennino, M. Vocanson, Y. Toussaint, K. Rodet, J. Benetiere, A.-M. Schmitt, M.-F. Aries, F. Berard, A. Rozieres, and J.-F. Nicolas Skin-Infiltrating CD8+ T Cells Initiate Atopic Dermatitis Lesions J. Immunol., May 1, 2007; 178(9): 5571 - 5577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.L. Seneviratne, A.P. Black, L. Jones, A.S. Bailey, and G.S. Ogg The role of skin-homing T cells in extrinsic atopic dermatitis QJM, January 1, 2007; 100(1): 19 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Ni, J. J. Campbell, G. Niehans, and B. Walcheck The Monoclonal Antibody CHO-131 Identifies a Subset of Cutaneous Lymphocyte-Associated Antigen T Cells Enriched in P-Selectin-Binding Cells J. Immunol., October 1, 2006; 177(7): 4742 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Savinko, A. Lauerma, S. Lehtimaki, M. Gombert, M.-L. Majuri, N. Fyhrquist-Vanni, M.-C. Dieu-Nosjean, L. Kemeny, H. Wolff, B. Homey, et al. Topical Superantigen Exposure Induces Epidermal Accumulation of CD8+ T Cells, a Mixed Th1/Th2-Type Dermatitis and Vigorous Production of IgE Antibodies in the Murine Model of Atopic Dermatitis J. Immunol., December 15, 2005; 175(12): 8320 - 8326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Vincent, X. Xiong, E. P. Grant, W. Peng, and M. B. Brenner CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens J. Immunol., November 15, 2005; 175(10): 6344 - 6351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Matheson, V. J. Johnson, and M. I. Luster Immune Mediators in a Murine Model for Occupational Asthma: Studies with Toluene Diisocyanate Toxicol. Sci., March 1, 2005; 84(1): 99 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Lee and R. A. Flavell Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma Int. Immunol., August 1, 2004; 16(8): 1155 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyahara, K. Takeda, T. Kodama, A. Joetham, C. Taube, J.-W. Park, S. Miyahara, A. Balhorn, A. Dakhama, and E. W. Gelfand Contribution of Antigen-Primed CD8+ T Cells to the Development of Airway Hyperresponsiveness and Inflammation Is Associated with IL-13 J. Immunol., February 15, 2004; 172(4): 2549 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Klunker, A. Trautmann, M. Akdis, J. Verhagen, P. Schmid-Grendelmeier, K. Blaser, and C. A. Akdis A Second Step of Chemotaxis After Transendothelial Migration: Keratinocytes Undergoing Apoptosis Release IFN-{gamma}-Inducible Protein 10, Monokine Induced by IFN-{gamma}, and IFN-{gamma}-Inducible {alpha}-Chemoattractant for T Cell Chemotaxis Toward Epidermis in Atopic Dermatitis J. Immunol., July 15, 2003; 171(2): 1078 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Lin, C.-T. Wang, C.-T. Hsu, L.-F. Wang, W.-Y. Shau, Y.-H. Yang, and B.-L. Chiang Differential Susceptibility to Staphylococcal Superantigen (SsAg)-Induced Apoptosis of CD4+ T Cells from Atopic Dermatitis Patients and Healthy Subjects: The Inhibitory Effect of IL-4 on SsAg-Induced Apoptosis J. Immunol., July 15, 2003; 171(2): 1102 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. AKDIS, A. TRAUTMANN, S. KLUNKER, I. DAIGLE, U. C. KUCUKSEZER, W. DEGLMANN, R. DISCH, K. BLASER, and C. A. AKDIS T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells FASEB J, June 1, 2003; 17(9): 1026 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gilliet, V. Soumelis, N. Watanabe, S. Hanabuchi, S. Antonenko, R. de Waal-Malefyt, and Y.-J. Liu Human Dendritic Cells Activated by TSLP and CD40L Induce Proallergic Cytotoxic T Cells J. Exp. Med., April 21, 2003; 197(8): 1059 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hudak, M. Hagen, Y. Liu, D. Catron, E. Oldham, L. M. McEvoy, and E. P. Bowman Immune Surveillance and Effector Functions of CCR10+ Skin Homing T Cells J. Immunol., August 1, 2002; 169(3): 1189 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yagi, H. Nagai, Y. Iigo, T. Akimoto, T. Arai, and M. Kubo Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC/Nga Mice J. Immunol., February 15, 2002; 168(4): 2020 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Michimata, H. Tsuda, M. Sakai, M. Fujimura, K. Nagata, M. Nakamura, and S. Saito Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D2-mediated manner Mol. Hum. Reprod., February 1, 2002; 8(2): 181 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vrtala, C. A. Akdis, F. Budak, M. Akdis, K. Blaser, D. Kraft, and R. Valenta T Cell Epitope-Containing Hypoallergenic Recombinant Fragments of the Major Birch Pollen Allergen, Bet v 1, Induce Blocking Antibodies J. Immunol., December 1, 2000; 165(11): 6653 - 6659. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
