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Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan;
Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan; and
Lord and Tayler Laboratory for Lung Biochemistry, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206
Pulmonary surfactant protein A (SP-A) plays an important part in
Ab-independent host defense mechanisms of the lung. In this study we
investigated how SP-A interacts with distinct serotypes of bacterial
LPS and modulates LPS-elicited cellular responses. SP-A bound to rough
forms but not to smooth forms of LPS. In the macrophage-like cell line
U937, SP-A inhibited mRNA expression and secretion of TNF-
induced
by smooth LPS, but rough LPS-induced TNF- expression was unaffected
by SP-A. When U937 cells and rat alveolar macrophages were preincubated
with SP-A, smooth LPS failed to induce TNF- secretion, whereas rough
LPS-induced TNF- secretion was modestly increased. To clarify the
mechanism by which SP-A modulates LPS-elicited cellular responses, we
further examined the interaction of SP-A with CD14, which is known as a
major LPS receptor. Western blot analysis revealed that CD14 was one of
the SP-A binding proteins isolated from solubilized U937 cells. In
addition, SP-A directly bound to recombinant soluble CD14 (rsCD14).
When rsCD14 was preincubated with SP-A, the binding of rsCD14 to smooth
LPS was significantly reduced but the association of rsCD14 with rough
LPS was augmented. These results demonstrate the different actions of
SP-A upon distinct serotypes of LPS and indicate that the direct
interaction of SP-A with CD14 constitutes a likely mechanism by which
SP-A modulates LPS-elicited cellular responses.
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D. Iwaki, H. Mitsuzawa, S. Murakami, H. Sano, M. Konishi, T. Akino, and Y. Kuroki The Extracellular Toll-like Receptor 2 Domain Directly Binds Peptidoglycan Derived from Staphylococcus aureus J. Biol. Chem., June 28, 2002; 277(27): 24315 - 24320. [Abstract] [Full Text] [PDF]
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L. Guillot, V. Balloy, F. X. McCormack, D. T. Golenbock, M. Chignard, and M. Si-Tahar Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4 J. Immunol., June 15, 2002; 168(12): 5989 - 5992. [Abstract] [Full Text] [PDF]
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H. Chiba, S. Pattanajitvilai, A. J. Evans, R. J. Harbeck, and D. R. Voelker Human Surfactant Protein D (SP-D) Binds Mycoplasma pneumoniae by High Affinity Interactions with Lipids J. Biol. Chem., May 31, 2002; 277(23): 20379 - 20385. [Abstract] [Full Text] [PDF]
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S. Murakami, D. Iwaki, H. Mitsuzawa, H. Sano, H. Takahashi, D. R. Voelker, T. Akino, and Y. Kuroki Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-alpha Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2 J. Biol. Chem., February 22, 2002; 277(9): 6830 - 6837. [Abstract] [Full Text] [PDF]
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O. A. Quintero and J. R. Wright Clearance of surfactant lipids by neutrophils and macrophages isolated from the acutely inflamed lung Am J Physiol Lung Cell Mol Physiol, February 1, 2002; 282(2): L330 - L339. [Abstract] [Full Text] [PDF]
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I. Nagaoka, S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, and D. Heumann Cathelicidin Family of Antibacterial Peptides CAP18 and CAP11 Inhibit the Expression of TNF-{alpha} by Blocking the Binding of LPS to CD14+ Cells J. Immunol., September 15, 2001; 167(6): 3329 - 3338. [Abstract] [Full Text] [PDF]
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J. M. Hickman-Davis, F. C. Fang, C. Nathan, V. L. Shepherd, D. R. Voelker, and J. R. Wright Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L517 - L523. [Abstract] [Full Text] [PDF]
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C. M. Fernandez-Prada, M. Nikolich, R. Vemulapalli, N. Sriranganathan, S. M. Boyle, G. G. Schurig, T. L. Hadfield, and D. L. Hoover Deletion of wboA Enhances Activation of the Lectin Pathway of Complement in Brucella abortus and Brucella melitensis Infect. Immun., July 1, 2001; 69(7): 4407 - 4416. [Abstract] [Full Text] [PDF]
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L. Salez, V. Balloy, N. van Rooijen, M. Lebastard, L. Touqui, F. X. McCormack, and M. Chignard Surfactant Protein A Suppresses Lipopolysaccharide-Induced IL-10 Production by Murine Macrophages J. Immunol., May 15, 2001; 166(10): 6376 - 6382. [Abstract] [Full Text] [PDF]
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J. R. Wright, P. Borron, K. G. Brinker, and R. J. Folz Surfactant Protein A . Regulation of Innate and Adaptive Immune Responses in Lung Inflammation Am. J. Respir. Cell Mol. Biol., May 1, 2001; 24(5): 513 - 517. [Full Text]
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H. Chiba, H. Sano, D. Iwaki, S. Murakami, H. Mitsuzawa, T. Takahashi, M. Konishi, H. Takahashi, and Y. Kuroki Rat Mannose-Binding Protein A Binds CD14 Infect. Immun., March 1, 2001; 69(3): 1587 - 1592. [Abstract] [Full Text] [PDF]
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 B. W. KRAMER, A. H. JOBE, C. J. BACHURSKI, and M. IKEGAMI Surfactant Protein A Recruits Neutrophils into the Lungs of Ventilated Preterm Lambs Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 158 - 165. [Abstract] [Full Text]
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R. G. SPRAGG and J. F. LEWIS Pathology of the Surfactant System of the Mature Lung . Second San Diego Conference Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 280 - 282. [Full Text]
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M. Song and D. S. Phelps Interaction of Surfactant Protein A with Lipopolysaccharide and Regulation of Inflammatory Cytokines in the THP-1 Monocytic Cell Line Infect. Immun., December 1, 2000; 68(12): 6611 - 6617. [Abstract] [Full Text] [PDF]
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C. Stamme, E. Walsh, and J. R. Wright Surfactant Protein A Differentially Regulates IFN-gamma - and LPS-Induced Nitrite Production by Rat Alveolar Macrophages Am. J. Respir. Cell Mol. Biol., December 1, 2000; 23(6): 772 - 779. [Abstract] [Full Text]
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P. Borron, J. C. McIntosh, T. R. Korfhagen, J. A. Whitsett, J. Taylor, and J. R. Wright Surfactant-associated protein A inhibits LPS-induced cytokine and nitric oxide production in vivo Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L840 - L847. [Abstract] [Full Text] [PDF]
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H. Sano, H. Chiba, D. Iwaki, H. Sohma, D. R. Voelker, and Y. Kuroki Surfactant Proteins A and D Bind CD14 by Different Mechanisms J. Biol. Chem., July 14, 2000; 275(29): 22442 - 22451. [Abstract] [Full Text] [PDF]
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