The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Antica, M.
Right arrow Articles by Scollay, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Antica, M.
Right arrow Articles by Scollay, R.
The Journal of Immunology, 1999, 163: 206-211.
Copyright © 1999 by The American Association of Immunologists

Development of T Lymphocytes at Extrathymic Sites

Mariastefania Antica1,* and Roland Scollay2,{dagger}

* Rudjer Boskovic Institute, Zagreb, Croatia; and {dagger} Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia

T lymphocytes expressing both CD4 and CD8 are the predominant cell type in the thymic cortex but are extremely rare outside the thymus of normal mice. In this article, we show that if precursor thymocytes (CD4-CD8-) from fetal or adult donors are injected i.v. into irradiated recipients, some of these cells will lodge in lymph nodes and develop into both CD4+CD8+ (double-positive) and CD4+ or CD8+ (single-positive) cells. This phenomenon also occurred in thymectomized recipients, strongly suggesting it is genuine extrathymic development. Prethymic precursors (e.g., fetal liver), were unable to use the lymph node for T cell development, without thymic processing. The data suggest that given unusual circumstances (irradiation or thymectomy and availability of appropriate precursors), the lymph nodes can support T cell development.




This article has been cited by other articles:


Home page
 BloodHome page
R. Terra, I. Louis, R. Le Blanc, S. Ouellet, J. C. Zuniga-Pflucker, and C. Perreault
T-cell generation by lymph node resident progenitor cells
Blood, July 1, 2005; 106(1): 193 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Samira, C. Ferrand, A. Peled, A. Nagler, Y. Tovbin, H. Ben-Hur, N. Taylor, A. Globerson, and T. Lapidot
Tumor Necrosis Factor Promotes Human T-Cell Development in Nonobese Diabetic/Severe Combined Immunodeficient Mice
Stem Cells, November 1, 2004; 22(6): 1085 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y.-W. Chu, S. A. Memon, S. O. Sharrow, F. T. Hakim, M. Eckhaus, P. J. Lucas, and R. E. Gress
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function
Blood, August 15, 2004; 104(4): 1110 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Louis, G. Dulude, S. Corneau, S. Brochu, C. Boileau, C. Meunier, C. Cote, N. Labrecque, and C. Perreault
Changes in the lymph node microenvironment induced by oncostatin M
Blood, August 15, 2003; 102(4): 1397 - 1404.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Terra, N. Labrecque, and C. Perreault
Thymic and Extrathymic T Cell Development Pathways Follow Different Rules
J. Immunol., July 15, 2002; 169(2): 684 - 692.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Boileau, M. Houde, G. Dulude, C. H. Clegg, and C. Perreault
Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M
J. Immunol., June 1, 2000; 164(11): 5713 - 5720.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1999 by The American Association of Immunologists, Inc. All rights reserved.