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- and Cell-to-Cell Contact-Dependent Cytotoxicity of Allograft-Induced Macrophages Against Syngeneic Tumor Cells and Cell Lines: An Application of Allografting to Cancer Treatment1
*
Department of Physiology, Osaka Medical College, Daigakumachi, Takatsuki, Japan;
Central Research Institute, Nissin Food Products Co., Ltd., Noji-cho, Kusatsu-shi, Shiga, Japan; and
Department of Urology, Gifu University School of Medicine, Tsukasa-machi, Gifu, Japan
In allogeneic tumor or skin transplantation, the rejection process
that destroys the allogeneic cells leaves syngeneic cells intact by
discrimination between self and nonself. Here, we examined whether the
cells infiltrating into the allografts could be cytotoxic against
syngeneic immortal cells in vitro and in vivo. The leukocytes (i.e.,
macrophages (M
; 55–65% of bulk infiltrates), granulocytes
(20–25%), and lymphocytes (15–20%)) infiltrating into allografts,
but not into autografts, in C57BL/6 mice were cytotoxic against
syngeneic tumor cells and cell lines, whereas the cytotoxic activity
was hardly induced in allografted, IFN-
-/- C57BL/6
mice. Among the leukocytes, M were the major population of cytotoxic
cells; and the cytotoxic activity appeared to be cell-to-cell contact
dependent. When syngeneic tumor cells were s.c. injected into normal
C57BL/6 mice simultaneously with the M-rich population or
allogeneic, but not syngeneic, fibroblastic cells, tumor growth was
suppressed in a cell number-dependent manner, and tumor cells were
rejected either with a M:tumor ratio of about 30 or with an
allograft:tumor ratio of 
200. In the case of
IFN--/- C57BL/6 mice, however, the s.c. injection of
the allograft simultaneously with tumor cells had no effect on the
tumor growth. These results suggest that allograft or allograft-induced
M may be applicable for use in cancer treatment and that IFN-
induction by the allograft may be crucial for the
treatment.
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