| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical Center, Worcester, MA 01655;
Department of Virology I, National Institute of Infectious Diseases, Toyama, Japan;
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand;
§
Queen Sirikit National Institute of Child Health (formerly Bangkok Children’s Hospital), Bangkok, Thailand; and
¶
Kamphaeng Phet Provincial Hospital, Kamphaeng Phet, Thailand
Decreased proliferative responses to mitogens and recall Ags have been observed in PBMC obtained during several acute human viral infections. To determine whether cell-mediated responses are altered during acute dengue infection, we examined the proliferative responses of PBMC from children enrolled in a prospective study of dengue infections in Thailand. All responses of PBMC during acute illness were compared with the same patients’ PBMC obtained at least 6 mo after their infection. Proliferative responses to PHA, anti-CD3, tetanus toxoid, and dengue Ags were decreased significantly in PBMC obtained during the acute infection. The proliferative responses to PHA were restored by the addition of gamma-irradiated autologous convalescent or allogeneic PBMC. Cell contact with the irradiated PBMC was necessary to restore proliferation. Non-T cells from the acute PBMC of dengue patients did not support proliferation of T cells from control donors in response to PHA, but T cells from the PBMC of patients with acute dengue proliferated if accessory cells from a control donor were present. Addition of anti-CD28 Abs restored anti-CD3-induced proliferation of the PBMC of some patients. The percentage of monocytes was reduced in the acute sample of PBMC of the dengue patients. Addition of IL-2 or IL-7, but not IL-4 or IL-12, also restored proliferation of acute PBMC stimulated with anti-CD3. The results demonstrate that both quantitative and qualitative defects in the accessory cell population during acute dengue illness result in a depression of in vitro T cell proliferation.
This article has been cited by other articles:
|
|
 |
|
  B. E. E. Martina, P. Koraka, and A. D. M. E. Osterhaus Dengue Virus Pathogenesis: an Integrated View Clin. Microbiol. Rev., October 1, 2009; 22(4): 564 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Warke, A. Becerra, A. Zawadzka, D. J. Schmidt, K. J. Martin, K. Giaya, J. H. Dinsmore, M. Woda, G. Hendricks, T. Levine, et al. Efficient dengue virus (DENV) infection of human muscle satellite cells upregulates type I interferon response genes and differentially modulates MHC I expression on bystander and DENV-infected cells J. Gen. Virol., July 1, 2008; 89(7): 1605 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tuuminen, E. Kekalainen, S. Makela, I. Ala-Houhala, F. A. Ennis, K. Hedman, J. Mustonen, A. Vaheri, and T. P. Arstila Human CD8+ T Cell Memory Generation in Puumala Hantavirus Infection Occurs after the Acute Phase and Is Associated with Boosting of EBV-Specific CD8+ Memory T Cells J. Immunol., August 1, 2007; 179(3): 1988 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Tilton, M. R. Luskin, A. J. Johnson, M. Manion, C. W. Hallahan, J. A. Metcalf, M. McLaughlin, R. T. Davey Jr., and M. Connors Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load J. Virol., March 15, 2007; 81(6): 2713 - 2725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Palmer, S. Fernandez, J. Bisbing, K. K. Peachman, M. Rao, D. Barvir, V. Gunther, T. Burgess, Y. Kohno, R. Padmanabhan, et al. Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells J. Gen. Virol., January 1, 2007; 88(1): 148 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Best, K. L. Morris, J. G. Shannon, S. J. Robertson, D. N. Mitzel, G. S. Park, E. Boer, J. B. Wolfinbarger, and M. E. Bloom Inhibition of Interferon-Stimulated JAK-STAT Signaling by a Tick-Borne Flavivirus and Identification of NS5 as an Interferon Antagonist J. Virol., October 15, 2005; 79(20): 12828 - 12839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. MABALIRAJAN, T. KADHIRAVAN, S. K. SHARMA, A. BANGA, and B. GHOSH TH2 IMMUNE RESPONSE IN PATIENTS WITH DENGUE DURING DEFERVESCENCE: PRELIMINARY EVIDENCE Am J Trop Med Hyg, June 1, 2005; 72(6): 783 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Palmer, P. Sun, C. Celluzzi, J. Bisbing, S. Pang, W. Sun, M. A. Marovich, and T. Burgess Differential Effects of Dengue Virus on Infected and Bystander Dendritic Cells J. Virol., February 15, 2005; 79(4): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Lin, S.-C. Chiu, Y.-L. Hsiao, S.-W. Wan, H.-Y. Lei, A.-L. Shiau, H.-S. Liu, T.-M. Yeh, S.-H. Chen, C.-C. Liu, et al. Expression of Cytokine, Chemokine, and Adhesion Molecules during Endothelial Cell Activation Induced by Antibodies against Dengue Virus Nonstructural Protein 1 J. Immunol., January 1, 2005; 174(1): 395 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G N Malavige, S Fernando, D J Fernando, and S L Seneviratne Dengue viral infections Postgrad. Med. J., October 1, 2004; 80(948): 588 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Iyasere, J. C. Tilton, A. J. Johnson, S. Younes, B. Yassine-Diab, R.-P. Sekaly, W. W. Kwok, S. A. Migueles, A. C. Laborico, W. L. Shupert, et al. Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2 J. Virol., October 15, 2003; 77(20): 10900 - 10909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-F. Lin, H.-Y. Lei, A.-L. Shiau, H.-S. Liu, T.-M. Yeh, S.-H. Chen, C.-C. Liu, S.-C. Chiu, and Y.-S. Lin Endothelial Cell Apoptosis Induced by Antibodies Against Dengue Virus Nonstructural Protein 1 Via Production of Nitric Oxide J. Immunol., July 15, 2002; 169(2): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Zivna, S. Green, D. W. Vaughn, S. Kalayanarooj, H. A. F. Stephens, D. Chandanayingyong, A. Nisalak, F. A. Ennis, and A. L. Rothman T Cell Responses to an HLA-B*07-Restricted Epitope on the Dengue NS3 Protein Correlate with Disease Severity J. Immunol., June 1, 2002; 168(11): 5959 - 5965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. McNeil, W. L. Shupert, C. A. Iyasere, C. W. Hallahan, J. Mican, R. T. Davey Jr., and M. Connors High-level HIV-1 viremia suppresses viral antigen-specific CD4+ T cell proliferation PNAS, November 20, 2001; 98(24): 13878 - 13883. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
