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*
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121; and
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543
Oncostatin M (OM) is a pleiotropic cytokine produced late in the
activation cycle of T cells and macrophages. In vitro it shares
properties with related proteins of the IL-6 family of cytokines;
however, its in vivo properties and physiological function are as yet
ill defined. We show that administration of OM inhibited bacterial
LPS-induced production of TNF-
and lethality in a dose-dependent
manner. Consistent with these findings, OM potently suppressed
inflammation and tissue destruction in murine models of rheumatoid
arthritis and multiple sclerosis. T cell function and Ab production
were not impaired by OM treatment. Taken together these data indicate
the activities of this cytokine in vivo are antiinflammatory without
concordant immunosuppression.
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