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Institut National de la Santé et de la Recherche Médicale Unité 345, Institut Necker, and
Centre National de la Recherche Scientifique, Unité de Recherche Associée 583, Hôpital Necker, Paris, France
Proliferation of murine T lymphocytes in blood, lymph nodes, and
spleen was studied in four in vivo stimulation systems, using BrdU
pulse-labeling of DNA-synthesizing cells. The T cell response to the
superantigen Staphylococcus enterotoxin B (SEB) was
studied in detail. Vß8+ T cells showed a peak of DNA
synthesis 16–24 h after SEB injection, and the percentage of
BrdU+ CD4 and CD8 T cells was higher in blood than in lymph
nodes and spleen. DNA synthesis was preceded by massive migration of
Vß8+ cells from blood to lymphoid organs, in which the
early activation marker CD69 was first up-regulated. SEB-nonspecific
Vß6+ cells showed minimal stimulation but, when cycling,
also expressed a high level of CD69. The other systems studied were
injection of the IFN-
inducer polyinosinic:polycytidylic acid,
infection by the BM5 variants of murine leukemia virus (the causative
agent of murine AIDS), and T cell expansion after transfer of normal
bone marrow and lymph node cells into recombinase-activating
gene-2-deficient mice. In each case, a peak of T cell proliferation was
observed in blood. These data demonstrate the extensive redistribution
of cycling T cells in the first few hours after activation. Kinetic
studies of blood lymphocyte status appear crucial for understanding
primary immune responses because cycling and redistributing T
lymphocytes are enriched in the circulating
compartment.
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