| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany;
Department of Internal Medicine, University of Saarland, Homburg, Germany; and
Departments of Medical Biophysics and Immunology, Ontario Cancer Institute and Amgen Institute, Toronto, Ontario, Canada
In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.
This article has been cited by other articles:
|
|
 |
|
  K.-i. Seino and M. Taniguchi Functionally distinct NKT cell subsets and subtypes J. Exp. Med., December 19, 2005; 202(12): 1623 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Matsumoto, E. Kubota, Y. Omi, U. Lee, and J. M. Penninger Essential Role of LFA-1 in Activating Th2-Like Responses by {alpha}-Galactosylceramide-Activated NKT Cells J. Immunol., October 15, 2004; 173(8): 4976 - 4984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Shibolet, Y. Kalish, A. Klein, R. Alper, L. Zolotarov, B. Thalenfeld, D. Engelhardt, E. Rabbani, and Y. Ilan Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis J. Leukoc. Biol., January 1, 2004; 75(1): 76 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Emoto, M. Miyamoto, Y. Emoto, I. Yoshizawa, V. Brinkmann, N. van Rooijen, and S. H. E. Kaufmann Highly Biased Type 1 Immune Responses in Mice Deficient in LFA-1 in Listeria monocytogenes Infection Are Caused by Elevated IL-12 Production by Granulocytes J. Immunol., October 15, 2003; 171(8): 3970 - 3976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Emoto, Y. Emoto, V. Brinkmann, M. Miyamoto, I. Yoshizawa, M. Staber, N. van Rooijen, A. Hamann, and S. H. E. Kaufmann Increased Resistance of LFA-1-Deficient Mice to Lipopolysaccharide-Induced Shock/Liver Injury in the Presence of TNF-{alpha} and IL-12 Is Mediated by IL-10: A Novel Role for LFA-1 in the Regulation of the Proinflammatory and Anti-Inflammatory Cytokine Balance J. Immunol., July 15, 2003; 171(2): 584 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matsumoto, S. Tsunematsu, K.-i. Tsukinoki, Y. Ohmi, M. Iwamiya, A. Oliveira-dos-Santos, D. Tone, J. Shindo, and J. M. Penninger Essential Role of the Adhesion Receptor LFA-1 for T Cell-Dependent Fulminant Hepatitis J. Immunol., December 15, 2002; 169(12): 7087 - 7096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dunussi-Joannopoulos, K. Zuberek, K. Runyon, R. G. Hawley, A. Wong, J. Erickson, S. Herrmann, and J. P. Leonard Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses Blood, August 13, 2002; 100(5): 1551 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Mannoor, R. C. Halder, S. R. M. Morshed, A. Ariyasinghe, H. Y. Bakir, H. Kawamura, H. Watanabe, H. Sekikawa, and T. Abo Essential Role of Extrathymic T Cells in Protection Against Malaria J. Immunol., July 1, 2002; 169(1): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Apostolou, A. Cumano, G. Gachelin, and P. Kourilsky Evidence for Two Subgroups of CD4-CD8- NKT Cells with Distinct TCR{alpha}{beta} Repertoires and Differential Distribution in Lymphoid Tissues J. Immunol., September 1, 2000; 165(5): 2481 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Miyamoto, M. Emoto, V. Brinkmann, N. van Rooijen, R. Schmits, E. Kita, and S. H. E. Kaufmann Cutting Edge: Contribution of NK Cells to the Homing of Thymic CD4+NKT Cells to the Liver J. Immunol., August 15, 2000; 165(4): 1729 - 1732. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
