| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B in IL-18-Induced IFN-
Expression in KG-1 Cells
Fujisaki Institute, Hayashibara Biochemical Laboratories Inc., Fujisaki, Okayama, Japan
IL-18 is a multifunctional cytokine playing various regulatory
roles in the immune system including induced cytokine production. As a
part of our ongoing studies on the molecular mechanisms of
IL-18-induced IFN-
production, we have examined the transcriptional
regulation of the IFN- gene by IL-18 in a human myelomonocytic cell
line, KG-1. On the basis of DNA/protein binding, we have determined an
IL-18-inducible NF-
B binding site located at -786 to -776 of the
IFN- gene regulatory region (designated KBBsite). Transient
transfection of promoter-reporter gene constructs revealed that the
KBBsite is required for full IL-18-induced activation of the IFN-
gene transcription induced by IL-18. In addition, stable transformants
of a dominant-negative form of the IB
showed an inhibition of
IL-18-dependent IB degradation, NF-B activation, and
expression of IFN-. These results are the first to show the actual
significance of the NF-B pathway in the regulation of IFN- gene
expression by IL-18.
This article has been cited by other articles:
|
|
 |
|
  M. Bachmann, C. Dragoi, M. A. Poleganov, J. Pfeilschifter, and H. Muhl Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-{kappa}B in acute myeloid leukemia-derived predendritic KG-1 cells Mol. Cancer Ther., February 1, 2007; 6(2): 723 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tato, N. Mason, D. Artis, S. Shapira, J. C. Caamano, J. H. Bream, H.-C. Liou, and C. A. Hunter Opposing roles of NF-{kappa}B family members in the regulation of NK cell proliferation and production of IFN-{gamma} Int. Immunol., April 1, 2006; 18(4): 505 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Yoo, H. Kwon, L.-Y. Khil, L. Zhang, H.-S. Jun, and J.-W. Yoon IL-18 Induces Monocyte Chemotactic Protein-1 Production in Macrophages through the Phosphatidylinositol 3-Kinase/Akt and MEK/ERK1/2 Pathways J. Immunol., December 15, 2005; 175(12): 8280 - 8286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Kim, G. Lenzen, A.-L. Page, P. Legrain, P. J. Sansonetti, and C. Parsot The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes PNAS, September 27, 2005; 102(39): 14046 - 14051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-K. Lee, S.-H. Kim, E. C. Lewis, T. Azam, L. L. Reznikov, and C. A. Dinarello Differences in signaling pathways by IL-1{beta} and IL-18 PNAS, June 8, 2004; 101(23): 8815 - 8820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Papadakis, J. L. Prehn, C. Landers, Q. Han, X. Luo, S. C. Cha, P. Wei, and S. R. Targan TL1A Synergizes with IL-12 and IL-18 to Enhance IFN-{gamma} Production in Human T Cells and NK Cells J. Immunol., June 1, 2004; 172(11): 7002 - 7007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Rothfuchs, C. Trumstedt, H. Wigzell, and M. E. Rottenberg Intracellular Bacterial Infection-Induced IFN-{gamma} Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN-{alpha}{beta}-STAT1 Signaling J. Immunol., May 15, 2004; 172(10): 6345 - 6353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Takahashi, H. Iwagaki, R. Tamura, D. Xue, M. Sano, S. Mori, T. Yoshino, N. Tanaka, and M. Nishibori Unique Regulation Profile of Prostaglandin E1 on Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells J. Pharmacol. Exp. Ther., December 1, 2003; 307(3): 1188 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Gracie, S. E. Robertson, and I. B. McInnes Interleukin-18 J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. M. Morel, C. C. Park, K. Zhu, P. Kumar, J. H. Ruth, and A. E. Koch Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression J. Biol. Chem., September 13, 2002; 277(38): 34679 - 34691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. D. Joshi, D. V. Kalvakolanu, J. D. Hasday, R. J. Hebel, and A. S. Cross IL-18 Levels and the Outcome of Innate Immune Response to Lipopolysaccharide: Importance of a Positive Feedback Loop with Caspase-1 in IL-18 Expression J. Immunol., September 1, 2002; 169(5): 2536 - 2544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Caamano and C. A. Hunter NF-{kappa}B Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions Clin. Microbiol. Rev., July 1, 2002; 15(3): 414 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, T. Azam, D. Novick, D.-Y. Yoon, L. L. Reznikov, P. Bufler, M. Rubinstein, and C. A. Dinarello Identification of Amino Acid Residues Critical for Biological Activity in Human Interleukin-18 J. Biol. Chem., March 22, 2002; 277(13): 10998 - 11003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gatti, J. Beck, G. Fantuzzi, T. Bartfai, and C. A. Dinarello Effect of interleukin-18 on mouse core body temperature Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R702 - R709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Takahashi, S. Saito, N. Ohtani, and T. Sakai Involvement of the Oct-1 Regulatory Element of the gadd45 Promoter in the p53-independent Response to Ultraviolet Irradiation Cancer Res., February 1, 2001; 61(3): 1187 - 1195. [Abstract] [Full Text]
|
|
|
|
|
|
S. Hyun Kim, L. L. Reznikov, R. J. L. Stuyt, C. H. Selzman, G. Fantuzzi, T. Hoshino, H. A. Young, and C. A. Dinarello Functional Reconstitution and Regulation of IL-18 Activity by the IL-18R{beta} Chain J. Immunol., January 1, 2001; 166(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Lawless, S. Zhang, O. N. Ozes, H. A. Bruns, I. Oldham, T. Hoey, M. J. Grusby, and M. H. Kaplan Stat4 Regulates Multiple Components of IFN-{gamma}-Inducing Signaling Pathways J. Immunol., December 15, 2000; 165(12): 6803 - 6808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Greene, G. Meachery, C. C. Taggart, C. P. Rooney, R. Coakley, S. J. O'Neill, and N. G. McElvaney Role of IL-18 in CD4+ T Lymphocyte Activation in Sarcoidosis J. Immunol., October 15, 2000; 165(8): 4718 - 4724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Smith, N. A. Bryant, and A. Alcamí Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins J. Gen. Virol., May 1, 2000; 81(5): 1223 - 1230. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Kaisho, H. Tsutsui, T. Tanaka, T. Tsujimura, K. Takeda, T. Kawai, N. Yoshida, K. Nakanishi, and S. Akira Impairment of Natural Killer Cytotoxic Activity and Interferon {gamma} Production in CCAAT/Enhancer Binding Protein {gamma}-deficient Mice J. Exp. Med., December 6, 1999; 190(11): 1573 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. M. Morel, C. C. Park, J. M. Woods, and A. E. Koch A Novel Role for Interleukin-18 in Adhesion Molecule Induction through NFkappa B and Phosphatidylinositol (PI) 3-Kinase-dependent Signal Transduction Pathways J. Biol. Chem., September 28, 2001; 276(40): 37069 - 37075. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
