| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan;
Division of Biochemistry, Research Institute, Miyagi Prefectural Cancer Center, Miyagi, Japan;
Second Department of Internal Medicine, Nagasaki University, School of Medicine, Nagasaki, Japan;
§
Department of Medical Biology, Kochi Medical School, Kochi, Japan; and
¶
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
Previous studies established that variable degrees and types of glycosylation can account for differences in the ability of CD44 to function as a receptor for hyaluronic acid. We have now used neuraminidase treatment to conclude that sialylation negatively regulates CD44 on the human monocytic cell line THP-1 and peripheral blood monocytes. Both of these cell types displayed increased receptor activity after overnight culture with LPS. Of particular interest, the sialidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid completely blocked the LPS induced recognition of hyaluronic acid by THP-1 cells. Furthermore, acquisition of this characteristic paralleled induction of one type of sialidase activity. Monocytes may be capable of enzymaticly remodeling cell surface CD44, altering their ability to interact with the extracellular matrix.
This article has been cited by other articles:
|
|
 |
|
  S. Katoh, N. Ishii, A. Nobumoto, K. Takeshita, S.-Y. Dai, R. Shinonaga, T. Niki, N. Nishi, A. Tominaga, A. Yamauchi, et al. Galectin-9 Inhibits CD44-Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 27 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Nan, I. Carubelli, and N. M. Stamatos Sialidase expression in activated human T lymphocytes influences production of IFN-{gamma} J. Leukoc. Biol., January 1, 2007; 81(1): 284 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Liang, V. Seyrantepe, K. Landry, R. Ahmad, A. Ahmad, N. M. Stamatos, and A. V. Pshezhetsky Monocyte Differentiation Up-regulates the Expression of the Lysosomal Sialidase, Neu1, and Triggers Its Targeting to the Plasma Membrane via Major Histocompatibility Complex Class II-positive Compartments J. Biol. Chem., September 15, 2006; 281(37): 27526 - 27538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhuo, A. Kanamori, R. Kannagi, N. Itano, J. Wu, M. Hamaguchi, N. Ishiguro, and K. Kimata SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum J. Biol. Chem., July 21, 2006; 281(29): 20303 - 20314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hernandez-Caselles, M. Martinez-Esparza, A. B. Perez-Oliva, A. M. Quintanilla-Cecconi, A. Garcia-Alonso, D. M. R. Alvarez-Lopez, and P. Garcia-Penarrubia A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing J. Leukoc. Biol., January 1, 2006; 79(1): 46 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hunt and D. R. Brown Mycoplasma alligatoris Infection Promotes CD95 (FasR) Expression and Apoptosis of Primary Cardiac Fibroblasts Clin. Vaccine Immunol., December 1, 2005; 12(12): 1370 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Mishra, S. Mishra, K. Gee, and A. Kumar Differential Involvement of Calmodulin-dependent Protein Kinase II-activated AP-1 and c-Jun N-terminal Kinase-activated EGR-1 Signaling Pathways in Tumor Necrosis Factor-{alpha} and Lipopolysaccharide-induced CD44 Expression in Human Monocytic Cells J. Biol. Chem., July 22, 2005; 280(29): 26825 - 26837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Stamatos, S. Curreli, D. Zella, and A. S. Cross Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines J. Leukoc. Biol., February 1, 2004; 75(2): 307 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mytar, M. Woloszyn, R. Szatanek, M. Baj-Krzyworzeka, M. Siedlar, I. Ruggiero, J. Wieckiewicz, and M. Zembala Tumor cell-induced deactivation of human monocytes J. Leukoc. Biol., December 1, 2003; 74(6): 1094 - 1101. [Abstract] [Full Text]
|
|
|
|
|
|
K. Gee, M. Kozlowski, and A. Kumar Tumor Necrosis Factor-{alpha} Induces Functionally Active Hyaluronan-adhesive CD44 by Activating Sialidase through p38 Mitogen-activated Protein Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells J. Biol. Chem., September 26, 2003; 278(39): 37275 - 37287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Delcommenne, R. Kannagi, and P. Johnson TNF-{alpha} increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans Glycobiology, October 1, 2002; 12(10): 613 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schwarzkopf, K.-P. Knobeloch, E. Rohde, S. Hinderlich, N. Wiechens, L. Lucka, I. Horak, W. Reutter, and R. Horstkorte Sialylation is essential for early development in mice PNAS, April 16, 2002; 99(8): 5267 - 5270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Day and G. D. Prestwich Hyaluronan-binding Proteins: Tying Up the Giant J. Biol. Chem., February 8, 2002; 277(7): 4585 - 4588. [Full Text] [PDF]
|
|
|
|
|
|
C. Termeer, H. Johannsen, T. Braun, A. Renkl, T. Ahrens, R. W. Denfeld, M. B. Lappin, J. M. Weiss, and J. C. Simon The role of CD44 during CD40 ligand-induced dendritic cell clustering and maturation J. Leukoc. Biol., November 1, 2001; 70(5): 715 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Brown, A. Maiti, and P. Johnson Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes J. Immunol., November 1, 2001; 167(9): 5367 - 5374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Dimitroff, J. Y. Lee, S. Rafii, R. C. Fuhlbrigge, and R. Sackstein CD44 Is a Major E-Selectin Ligand on Human Hematopoietic Progenitor Cells J. Cell Biol., June 11, 2001; 153(6): 1277 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Dimitroff, J. Y. Lee, R. C. Fuhlbrigge, and R. Sackstein A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells PNAS, November 22, 2000; (2000) 250484797. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Mummert, M. Mohamadzadeh, D. I. Mummert, N. Mizumoto, and A. Takashima Development of a Peptide Inhibitor of Hyaluronan-mediated Leukocyte Trafficking J. Exp. Med., September 11, 2000; 192(6): 769 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schwarzkopf, K.-P. Knobeloch, E. Rohde, S. Hinderlich, N. Wiechens, L. Lucka, I. Horak, W. Reutter, and R. Horstkorte Sialylation is essential for early development in mice PNAS, April 16, 2002; 99(8): 5267 - 5270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Dimitroff, J. Y. Lee, R. C. Fuhlbrigge, and R. Sackstein A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells PNAS, December 5, 2000; 97(25): 13841 - 13846. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
