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CUTTING EDGE |
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Department of Appropriate Technology Development,
Research Institute, International Medical Center of Japan, Tokyo, Japan; Departments of
Biochemistry and
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Immunology and Medical Zoology,
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Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan; and
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Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Japan
IL-18 is a proinflammatory cytokine that plays an important role
in NK cell activation and Th1 cell response. Recently IL-1R-related
protein (IL-1Rrp) has been cloned as the receptor for IL-18. However,
the functional role of IL-1Rrp is still controversial due to its low
affinity to IL-18 as well as the possibility of the presence of another
high-affinity binding receptor. In the present study, we have generated
and characterized IL-1Rrp-deficient mice. The binding of murine rIL-18
was not detected in Th1-developing splenic CD4+ T cells
isolated from IL-1Rrp-deficient mice. The activation of NF-
B or
c-Jun N-terminal kinase were also not observed in the Th1 cells. NK
cells from IL-1Rrp-deficient mice had defects in cytolytic activity and
IFN-
production in response to IL-18. Th1 cell development was also
impaired in IL-1Rrp-deficient mice. These data demonstrate that IL-1Rrp
is a ligand-binding receptor that is essential for IL-18-mediated
signaling events.
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T. Sareneva, I. Julkunen, and S. Matikainen IFN-{alpha} and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells J. Immunol., August 15, 2000; 165(4): 1933 - 1938. [Abstract] [Full Text] [PDF]
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M. G. Attur, M. N. Dave, R. M. Clancy, I. R. Patel, S. B. Abramson, and A. R. Amin Functional Genomic Analysis in Arthritis-Affected Cartilage: Yin-Yang Regulation of Inflammatory Mediators by {alpha}5{beta}1 and {alpha}V{beta}3 Integrins J. Immunol., March 1, 2000; 164(5): 2684 - 2691. [Abstract] [Full Text] [PDF]
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K. Tominaga, T. Yoshimoto, K. Torigoe, M. Kurimoto, K. Matsui, T. Hada, H. Okamura, and K. Nakanishi IL-12 synergizes with IL-18 or IL-1{beta} for IFN-{gamma} production from human T cells Int. Immunol., February 1, 2000; 12(2): 151 - 160. [Abstract] [Full Text] [PDF]
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T. Yoshimoto, H. Tsutsui, K. Tominaga, K. Hoshino, H. Okamura, S. Akira, W. E. Paul, and K. Nakanishi IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils PNAS, November 23, 1999; 96(24): 13962 - 13966. [Abstract] [Full Text] [PDF]
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L. L. Reznikov, S.-H. Kim, J. Y. Westcott, J. Frishman, G. Fantuzzi, D. Novick, M. Rubinstein, and C. A. Dinarello IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma PNAS, February 29, 2000; 97(5): 2174 - 2179. [Abstract] [Full Text] [PDF]
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A. Bowie, E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower, and L. A. J. O'Neill A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling PNAS, August 29, 2000; 97(18): 10162 - 10167. [Abstract] [Full Text] [PDF]
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