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CUTTING EDGE |
T Lymphocytes1
Departments of
*
Pathology, Microbiology, and Immunology, and
Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616; and
Department of Medical Microbiology, School of Medicine, University of California, Davis, CA 95616
intraepithelial lymphocytes are thought to coordinate
responses to pathogens that penetrate the epithelial barrier. To
directly test this, mice were inoculated with Nocardia
asteroides. At doses that were nonlethal for control mice,
-deficient mice became severely ill and died within 14 days.
Histologic examination of these lungs demonstrated the presence of
severe tissue damage and unimpeded bacterial growth in the
-deficient mice compared with neutrophilic lesions and clearance
of the organism in control mice. Interestingly, ozone exposure that
targets a comparable lung region also resulted in diffuse epithelial
necrosis associated with a similar lack of neutrophil recruitment in
-deficient mice. These data demonstrate that
intraepithelial lymphocytes can protect the host from pathogenic and
nonpathogenic insults by targeting the inflammatory response to
epithelial necrosis.
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