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T Cell Subset, Which Is Found in Large Numbers in the Spleen, Accumulates Inefficiently in an Artificial Site of Inflammation: Correlation with Lack of Expression of E-Selectin Ligands and L-Selectin1
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717
Tissue-specific localization of TCR-defined subsets of 
T
cells has been widely reported; however, the mechanisms responsible for
this phenomenon are poorly understood. We describe a bovine T
cell TCR-associated subset that preferentially localizes in the spleen.
This subset was characterized by coexpression of CD8, and was found to
lack surface expression of E-selectin ligands, GR Ag ligands, as well
as low expression of L-selectin. The CD8-positive T cell subset
did not accumulate at sites of inflammation as efficiently as
CD8-negative T cells that, in contrast, express E-selectin and
GR ligands and high levels of L-selectin. This is the first
demonstration of a T cell subset, which exhibits a defined
tissue tropism, having a unique adhesion molecule expression profile.
These results demonstrate that in some cases tissue-specific
accumulation of T cell subsets can be predicted by expression,
or lack of expression, of defined homing
molecules.
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