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T Cell Subset1
*
National Jewish Medical and Research Center, Denver, CO 80206; and
Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262
Whether 
T lymphocytes respond to microbial Ags or to
inducible host Ags remains a matter of controversy. Using several
different disease models and mouse strains, we and others have seen
that V6/V1 T cells preferentially increase among the
T cells infiltrating inflamed tissues. However, it was not clear
whether bacteria are necessary to bring about this response. Therefore,
we have reexamined this question using a disease model in which
inflammation is induced by a purely autoimmune process involving no
bacteria, bacterial products, or other foreign material: testicular
cell-induced autoimmune orchitis. Using this model we found that
T cells were still plentiful among the infiltrating T lymphocytes,
being 9- to 10-fold more prevalent than in spleen, and that
V6/V1+ cells again represented the predominant
T cell type. This finding shows that the response of the
V6/V1+ subset does not, in fact, depend upon the
presence of bacteria or bacterial products. The stimulus triggering the
response of the V6/V1 T cells appears to be neither
foreign nor organ-specific in origin, but instead consists of a
self-derived host Ag or signal induced during the inflammatory
process.
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